fluorouracil has been researched along with Polyploid in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells." | 7.78 | [Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole]. ( Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB, 2012) |
| "To identify the prognostically highest risk patients, DNA content and p53 nuclear or cytoplasmic accumulation, evaluated by monoclonal antibody DO7 and polyclonal antibody CM1, were determined in 94 surgically resected stage II (Dukes B2) colorectal cancers, treated or not with adjuvant 5-fluorouracil-based chemotherapy." | 7.71 | p53 nuclear accumulation and multiploidy are adverse prognostic factors in surgically resected stage II colorectal cancers independent of fluorouracil-based adjuvant therapy. ( Benevolo, M; Brenna, A; Buglioni, S; Cosimelli, M; D'Agnano, I; D'Angelo, C; Mottolese, M; Perrone Donnorso, R; Vasselli, S; Zupi, G, 2001) |
| "Nocodazole in a dose of 100 ng/ml was used to induce polyploidization in a breast cancer cell line MDA-MB-231 cells." | 3.78 | [Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole]. ( Hao, J; Liu, GY; Wang, DH; Xu, YF; Yu, J; Yuan, BB, 2012) |
| "To identify the prognostically highest risk patients, DNA content and p53 nuclear or cytoplasmic accumulation, evaluated by monoclonal antibody DO7 and polyclonal antibody CM1, were determined in 94 surgically resected stage II (Dukes B2) colorectal cancers, treated or not with adjuvant 5-fluorouracil-based chemotherapy." | 3.71 | p53 nuclear accumulation and multiploidy are adverse prognostic factors in surgically resected stage II colorectal cancers independent of fluorouracil-based adjuvant therapy. ( Benevolo, M; Brenna, A; Buglioni, S; Cosimelli, M; D'Agnano, I; D'Angelo, C; Mottolese, M; Perrone Donnorso, R; Vasselli, S; Zupi, G, 2001) |
| "Treatment of HCT-116 and Caco-2 colon cancer cells with the hypoxia mimic CoCl2 induced the formation of cells with larger cell and nuclear size (PGCCs), while the cells with normal morphology were selectively eliminated." | 1.40 | CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer. ( Aranda, E; De la Haba-Rodríguez, JR; Hernandez, V; Jimenez, C; Lopez-Pedrera, C; Lopez-Sánchez, LM; Martinez, A; Muñoz-Castañeda, JR; Peñarando, J; Rodriguez-Ariza, A; Valverde, A, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lopez-Sánchez, LM | 1 |
| Jimenez, C | 1 |
| Valverde, A | 1 |
| Hernandez, V | 1 |
| Peñarando, J | 1 |
| Martinez, A | 1 |
| Lopez-Pedrera, C | 1 |
| Muñoz-Castañeda, JR | 1 |
| De la Haba-Rodríguez, JR | 1 |
| Aranda, E | 1 |
| Rodriguez-Ariza, A | 1 |
| Hao, J | 1 |
| Yuan, BB | 1 |
| Xu, YF | 1 |
| Yu, J | 1 |
| Liu, GY | 1 |
| Wang, DH | 1 |
| Buglioni, S | 1 |
| D'Agnano, I | 1 |
| Vasselli, S | 1 |
| Perrone Donnorso, R | 1 |
| D'Angelo, C | 1 |
| Brenna, A | 1 |
| Benevolo, M | 1 |
| Cosimelli, M | 1 |
| Zupi, G | 1 |
| Mottolese, M | 1 |
| Carlson, PS | 1 |
4 other studies available for fluorouracil and Polyploid
| Article | Year |
|---|---|
CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.
Topics: Adenocarcinoma; Cell Division; Cell Hypoxia; Cell Line, Tumor; Cell Shape; Cobalt; Colonic Neoplasms | 2014 |
[Sensitivity to chemotherapeutic drugs of polyploid tumor cells induced by a spindle poison nocodazole].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tu | 2012 |
p53 nuclear accumulation and multiploidy are adverse prognostic factors in surgically resected stage II colorectal cancers independent of fluorouracil-based adjuvant therapy.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Cell Nucleus; Chemotherapy, Adjuvant; Colorectal Neopla | 2001 |
Notes on the mechanism of action of gibberellic acid.
Topics: Amylases; Aneuploidy; Calcium; Diploidy; Edible Grain; Enzyme Induction; Fluorouracil; Genes; Geneti | 1972 |