fluorouracil has been researched along with Poliomyelitis in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Poliomyelitis: An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation or demyelination was not detected in brains or spinal cords of noninfected SJL mice treated with 5-FU and/or LE." | 1.30 | 5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus. ( Kimmel, DW; Lucchinetti, CF; Pavelko, K; Rodriguez, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campagnola, G | 1 |
| Gong, P | 1 |
| Peersen, OB | 1 |
| LODDO, B | 1 |
| MUNYON, W | 1 |
| SALZMAN, NP | 1 |
| Lucchinetti, CF | 1 |
| Kimmel, DW | 1 |
| Pavelko, K | 1 |
| Rodriguez, M | 1 |
4 other studies available for fluorouracil and Poliomyelitis
| Article | Year |
|---|---|
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
Topics: Allosteric Regulation; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; F | 2011 |
[Inhibition of the multiplication in vitro of poliomyelitis virus by the action of guanidine. XI. Potentiation of the anti-poliomyelitic effect of guanidine by 5-fluorouracil].
Topics: Amidines; Fluorouracil; Guanidine; Guanidines; In Vitro Techniques; Poliomyelitis; Poliovirus; Uraci | 1962 |
The incorporation of 5-fluoro-uracil into poliovirus.
Topics: Fluorouracil; Poliomyelitis; Poliovirus; RNA; Uracil | 1962 |
5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus.
Topics: Adjuvants, Immunologic; Animals; Antimetabolites, Antineoplastic; Demyelinating Diseases; Female; Fl | 1997 |