Page last updated: 2024-10-27

fluorouracil and Pneumonia

fluorouracil has been researched along with Pneumonia in 22 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Pneumonia: Infection of the lung often accompanied by inflammation.

Research Excerpts

ExcerptRelevanceReference
"Five hundred and twenty-four breast cancer patients were prospectively and randomly assigned to receive either four cycles of paclitaxel followed by four cycles of 5-fluorouracil, doxorubicin, cyclophosphamide (FAC) or eight cycles of FAC."9.11Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients. ( Buchholz, TA; Buzdar, AU; Hortobagyi, GN; Kau, SW; McNeese, MD; Perkins, GH; Schechter, NR; Strom, EA; Thames, HD; Thomas, ES; Whitman, GJ; Yu, TK, 2004)
"Five hundred and twenty-four breast cancer patients were prospectively and randomly assigned to receive either four cycles of paclitaxel followed by four cycles of 5-fluorouracil, doxorubicin, cyclophosphamide (FAC) or eight cycles of FAC."5.11Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients. ( Buchholz, TA; Buzdar, AU; Hortobagyi, GN; Kau, SW; McNeese, MD; Perkins, GH; Schechter, NR; Strom, EA; Thames, HD; Thomas, ES; Whitman, GJ; Yu, TK, 2004)
"We conducted a prospective study in esophageal cancer patients who received nCT (n  =  126) or nCRT (n  =  141) prior to surgery."2.84Impact of neoadjuvant chemotherapy and chemoradiotherapy on postoperative cardiopulmonary complications in patients with esophageal cancer. ( Zhang, H; Zhang, Z, 2017)
"Patient survival in esophageal cancer (EC) remains poor."2.80A Phase 1/2 Study of Definitive Chemoradiation Therapy Using Docetaxel, Nedaplatin, and 5-Fluorouracil (DNF-R) for Esophageal Cancer. ( Hayashi, T; Hirakawa, M; Hori, M; Kato, J; Kobune, M; Miyanishi, K; Nakata, K; Ohnuma, H; Okagawa, Y; Osuga, T; Sagawa, T; Sakata, K; Sato, T; Sato, Y; Someya, M; Takayama, T; Takimoto, R, 2015)
"5-Fluorouracil was infused 24 hours per day throughout the period of radiation at a dose of 300 mg/m2/day for a median of 42 days (range, 28-56 days)."2.66Concomitant 5-fluorouracil infusion and high-dose radiation for stage III non-small cell lung cancer. ( Chaffey, J; Lokich, J; Neptune, W, 1989)
"The prognostic impact of postoperative anastomotic leakage (AL) and pneumonia on survival was evaluated."1.91Old age and intense chemotherapy exacerbate negative prognostic impact of postoperative complication on survival in patients with esophageal cancer who received neoadjuvant therapy: a nationwide study from 85 Japanese esophageal centers. ( Doki, Y; Kakeji, Y; Kawakubo, H; Kitagawa, Y; Matsuda, S; Muto, M; Okamura, A; Okui, J; Takemura, R; Takeuchi, H; Watanabe, M, 2023)
"A PPC was defined as pneumonia or acute respiratory distress syndrome within 30 days after surgery."1.42Serum Transforming Growth Factor-β1 Change After Neoadjuvant Chemoradiation Therapy Is Associated With Postoperative Pulmonary Complications in Esophageal Cancer Patients Undergoing Combined Modality Therapy. ( Chang, DT; Cheng, JC; Hsu, CH; Hsu, FM; Huang, PM; Koong, AC; Lee, JM; Lu, SL; Tsai, CL; Wu, JK, 2015)
"Squamous cell carcinoma was an adverse factor related to increased postoperative pulmonary complications."1.36High-dose preoperative chemoradiotherapy in esophageal cancer patients does not increase postoperative pulmonary complications: correlation with dose-volume histogram parameters. ( Hurmuzlu, M; Muren, LP; Smaaland, R; Viste, A; Wentzel-Larsen, T; Øvrebø, K, 2010)
"Gemcitabine is a pyrimidine antimetabolite with activity in a number of cancers."1.35Gemcitabine-induced pulmonary toxicity during adjuvant therapy in a patient with pancreatic cancer. ( Cornfeld, D; Lansigan, F; Saif, MW; Shaib, W; Syrigos, K, 2008)
"Data from 110 esophageal cancer patients treated between January 1998 and December 2003 were analyzed retrospectively."1.33Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery. ( Ajani, JA; Cox, JD; Komaki, R; Liao, Z; Liu, H; Swisher, S; Tucker, SL; Vaporciyan, AA; Wang, SL; Wei, X, 2006)
"Fluorouracil-induced pneumonitis was subsequently diagnosed."1.30[A case of fluorouracil-induced pneumonitis]. ( Andou, H; Itoh, K; Tsuda, T, 1997)
" Preoperative chemoradiotherapy consisted of cisplatinum combined chemotherapy and radiotherapy (total dosage of 30-70 Gy)."1.30Analysis of postoperative complications after esophagectomy for esophageal cancer in patients receiving neoadjuvant therapy. ( Eguchi, R; Hayashi, K; Ide, H; Itoh, H; Nakamura, T; Ohta, M; Okamoto, F; Takasaki, K, 1999)
"Seventeen patients with metastatic breast carcinoma were treated with a combination of 5-fluorouracil, methotrexate, vincristine, cyclophosphamide and prednisone."1.25Nonbacterial pneumonitis with multidrug antineoplastic therapy in breast carcinoma. ( Blom, J; Stutz, FH; Tormey, DC, 1973)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19906 (27.27)18.7374
1990's3 (13.64)18.2507
2000's6 (27.27)29.6817
2010's6 (27.27)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Matsuda, S1
Kitagawa, Y1
Okui, J1
Okamura, A1
Kawakubo, H1
Takemura, R1
Muto, M1
Kakeji, Y1
Takeuchi, H1
Watanabe, M1
Doki, Y1
Zhang, Z1
Zhang, H1
Ohnuma, H1
Sato, Y1
Hirakawa, M1
Okagawa, Y1
Osuga, T1
Hayashi, T1
Sato, T1
Miyanishi, K1
Kobune, M1
Takimoto, R1
Sagawa, T1
Hori, M1
Someya, M1
Nakata, K1
Sakata, K1
Takayama, T1
Kato, J1
Lu, SL1
Hsu, FM1
Tsai, CL1
Wu, JK1
Lee, JM1
Huang, PM1
Hsu, CH1
Koong, AC1
Chang, DT1
Cheng, JC1
Zhang, P1
Xi, M1
Li, QQ1
Hu, YH1
Guo, X1
Zhao, L1
Liu, H2
Liu, SL1
Luo, LL1
Liu, Q1
Liu, MZ1
Shaib, W1
Lansigan, F1
Cornfeld, D1
Syrigos, K1
Saif, MW1
Dähn, D1
Martell, J1
Vorwerk, H1
Hess, CF1
Becker, H1
Jung, K1
Hilgers, R1
Wolff, HA1
Hermann, RM1
Christiansen, H1
Hurmuzlu, M1
Øvrebø, K1
Wentzel-Larsen, T1
Muren, LP1
Viste, A1
Smaaland, R1
Yu, TK1
Whitman, GJ1
Thames, HD1
Buzdar, AU1
Strom, EA1
Perkins, GH1
Schechter, NR1
McNeese, MD1
Kau, SW1
Thomas, ES1
Hortobagyi, GN1
Buchholz, TA1
Hirano, A1
Tanimoto, Y1
Kimura, G1
Kiura, K1
Ueoka, H1
Kataoka, M1
Tanimoto, M1
Wang, SL1
Liao, Z1
Vaporciyan, AA1
Tucker, SL1
Wei, X1
Swisher, S1
Ajani, JA1
Cox, JD1
Komaki, R1
Lee, DH1
Han, JY1
Yoon, SM1
Lee, JJ1
Lee, HG1
Kim, HY1
Yoon, SJ1
Hong, EK1
Lee, JS1
Andou, H1
Itoh, K1
Tsuda, T1
Eguchi, R1
Ide, H1
Nakamura, T1
Hayashi, K1
Ohta, M1
Okamoto, F1
Itoh, H1
Takasaki, K1
Doddoli, C1
Thomas, P1
Reynaud-Gaubert, M1
Giudicelli, R1
Papazian, L1
Fuentes, P1
Samuels, ML1
Holoye, PY1
Johnson, DE1
Manheimer, F1
Aranda, CP1
Smith, RL1
Lokich, J1
Chaffey, J1
Neptune, W1
Tallósy, I1
Vargha, G1
Pölöskey, A1
Nagy, Z1
Kricskovits, A1
Stutz, FH2
Blom, J2
Tormey, DC2

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intensity Modulated Radiation Therapy for Breast Cancer: A Phase I Feasibility Study[NCT00594477]Phase 1100 participants (Actual)Interventional2008-01-04Completed
A Phase II Trial of Dose Escalated Proton Beam Therapy or Photon Therapy for Resectable and Unresectable Esophageal Cancer[NCT03234842]Phase 20 participants (Actual)Interventional2017-10-30Withdrawn (stopped due to non-accrual)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for fluorouracil and Pneumonia

ArticleYear
Impact of neoadjuvant chemotherapy and chemoradiotherapy on postoperative cardiopulmonary complications in patients with esophageal cancer.
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2017, Apr-01, Volume: 30, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Adjuvant; Cisplatin;

2017
A Phase 1/2 Study of Definitive Chemoradiation Therapy Using Docetaxel, Nedaplatin, and 5-Fluorouracil (DNF-R) for Esophageal Cancer.
    International journal of radiation oncology, biology, physics, 2015, Oct-01, Volume: 93, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Disease-Free Survival; Doce

2015
Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients.
    Journal of the National Cancer Institute, 2004, Nov-17, Volume: 96, Issue:22

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan

2004
A pilot trial of gemcitabine and vinorelbine plus capecitabine in locally advanced or metastatic nonsmall cell lung cancer.
    American journal of clinical oncology, 2006, Volume: 29, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Car

2006
Concomitant 5-fluorouracil infusion and high-dose radiation for stage III non-small cell lung cancer.
    Cancer, 1989, Sep-01, Volume: 64, Issue:5

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Combined Modality Therapy; Esophagit

1989

Other Studies

17 other studies available for fluorouracil and Pneumonia

ArticleYear
Old age and intense chemotherapy exacerbate negative prognostic impact of postoperative complication on survival in patients with esophageal cancer who received neoadjuvant therapy: a nationwide study from 85 Japanese esophageal centers.
    Esophagus : official journal of the Japan Esophageal Society, 2023, Volume: 20, Issue:3

    Topics: Aged; Anastomotic Leak; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; East A

2023
Serum Transforming Growth Factor-β1 Change After Neoadjuvant Chemoradiation Therapy Is Associated With Postoperative Pulmonary Complications in Esophageal Cancer Patients Undergoing Combined Modality Therapy.
    International journal of radiation oncology, biology, physics, 2015, Dec-01, Volume: 93, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bridged-Ring Compoun

2015
Concurrent cisplatin and 5-fluorouracil versus concurrent cisplatin and docetaxel with radiotherapy for esophageal squamous cell carcinoma: a propensity score-matched analysis.
    Oncotarget, 2016, Jul-12, Volume: 7, Issue:28

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe

2016
Gemcitabine-induced pulmonary toxicity during adjuvant therapy in a patient with pancreatic cancer.
    JOP : Journal of the pancreas, 2008, Nov-03, Volume: 9, Issue:6

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Capecitabine; Chemotherapy, Adjuvant; Deoxycy

2008
Influence of irradiated lung volumes on perioperative morbidity and mortality in patients after neoadjuvant radiochemotherapy for esophageal cancer.
    International journal of radiation oncology, biology, physics, 2010, May-01, Volume: 77, Issue:1

    Topics: Acute Lung Injury; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplat

2010
High-dose preoperative chemoradiotherapy in esophageal cancer patients does not increase postoperative pulmonary complications: correlation with dose-volume histogram parameters.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 97, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chi-Square Di

2010
[A case of pneumonitis induced by CDDP and 5-FU].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2005, Volume: 43, Issue:5

    Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamid

2005
Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery.
    International journal of radiation oncology, biology, physics, 2006, Mar-01, Volume: 64, Issue:3

    Topics: Analysis of Variance; Camptothecin; Combined Modality Therapy; Esophageal Neoplasms; Female; Fluorou

2006
[A case of fluorouracil-induced pneumonitis].
    Nihon Kyobu Shikkan Gakkai zasshi, 1997, Volume: 35, Issue:10

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Drug Hypersensitivity; Fluorouracil; Hu

1997
Analysis of postoperative complications after esophagectomy for esophageal cancer in patients receiving neoadjuvant therapy.
    The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 1999, Volume: 47, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Esophageal Neoplasms; Esophagectomy; Fluo

1999
[Postoperative complications after radiochemotherapy or chemotherapy for bronchial cancers].
    Revue des maladies respiratoires, 2000, Volume: 17, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bronchial Fistula; Carcinoma, Bronchoge

2000
Bleomycin combination chemotherapy in the management of testicular neoplasia.
    Cancer, 1975, Volume: 36, Issue:2

    Topics: Abdominal Neoplasms; Adult; Bleomycin; Cyclophosphamide; Drug Therapy, Combination; Dysgerminoma; Fl

1975
Necrotizing pneumonitis caused by 5-fluorouracil infusion. A complication of a Hickman catheter.
    Cancer, 1992, Jul-15, Volume: 70, Issue:2

    Topics: Aged; Brachiocephalic Veins; Catheters, Indwelling; Fluorouracil; Foreign-Body Migration; Humans; In

1992
[Analysis of alveolitis (pneumonitis) as a complication of cytostatic (CMF) therapy].
    Orvosi hetilap, 1987, Aug-02, Volume: 128, Issue:31

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fluorour

1987
Case 6-1985: progressive pneumonitis after chemotherapy for breast cancer.
    The New England journal of medicine, 1985, Jul-04, Volume: 313, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fluorour

1985
Combination chemotherapy in disseminated carcinoma of the breast.
    Oncology, 1974, Volume: 29, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Evaluation Stu

1974
Nonbacterial pneumonitis with multidrug antineoplastic therapy in breast carcinoma.
    Canadian Medical Association journal, 1973, Mar-17, Volume: 108, Issue:6

    Topics: Adenocarcinoma; Adrenalectomy; Adult; Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Huma

1973