fluorouracil has been researched along with Pneumonia in 22 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Pneumonia: Infection of the lung often accompanied by inflammation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five hundred and twenty-four breast cancer patients were prospectively and randomly assigned to receive either four cycles of paclitaxel followed by four cycles of 5-fluorouracil, doxorubicin, cyclophosphamide (FAC) or eight cycles of FAC." | 9.11 | Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients. ( Buchholz, TA; Buzdar, AU; Hortobagyi, GN; Kau, SW; McNeese, MD; Perkins, GH; Schechter, NR; Strom, EA; Thames, HD; Thomas, ES; Whitman, GJ; Yu, TK, 2004) |
| "Five hundred and twenty-four breast cancer patients were prospectively and randomly assigned to receive either four cycles of paclitaxel followed by four cycles of 5-fluorouracil, doxorubicin, cyclophosphamide (FAC) or eight cycles of FAC." | 5.11 | Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients. ( Buchholz, TA; Buzdar, AU; Hortobagyi, GN; Kau, SW; McNeese, MD; Perkins, GH; Schechter, NR; Strom, EA; Thames, HD; Thomas, ES; Whitman, GJ; Yu, TK, 2004) |
| "We conducted a prospective study in esophageal cancer patients who received nCT (n = 126) or nCRT (n = 141) prior to surgery." | 2.84 | Impact of neoadjuvant chemotherapy and chemoradiotherapy on postoperative cardiopulmonary complications in patients with esophageal cancer. ( Zhang, H; Zhang, Z, 2017) |
| "Patient survival in esophageal cancer (EC) remains poor." | 2.80 | A Phase 1/2 Study of Definitive Chemoradiation Therapy Using Docetaxel, Nedaplatin, and 5-Fluorouracil (DNF-R) for Esophageal Cancer. ( Hayashi, T; Hirakawa, M; Hori, M; Kato, J; Kobune, M; Miyanishi, K; Nakata, K; Ohnuma, H; Okagawa, Y; Osuga, T; Sagawa, T; Sakata, K; Sato, T; Sato, Y; Someya, M; Takayama, T; Takimoto, R, 2015) |
| "5-Fluorouracil was infused 24 hours per day throughout the period of radiation at a dose of 300 mg/m2/day for a median of 42 days (range, 28-56 days)." | 2.66 | Concomitant 5-fluorouracil infusion and high-dose radiation for stage III non-small cell lung cancer. ( Chaffey, J; Lokich, J; Neptune, W, 1989) |
| "The prognostic impact of postoperative anastomotic leakage (AL) and pneumonia on survival was evaluated." | 1.91 | Old age and intense chemotherapy exacerbate negative prognostic impact of postoperative complication on survival in patients with esophageal cancer who received neoadjuvant therapy: a nationwide study from 85 Japanese esophageal centers. ( Doki, Y; Kakeji, Y; Kawakubo, H; Kitagawa, Y; Matsuda, S; Muto, M; Okamura, A; Okui, J; Takemura, R; Takeuchi, H; Watanabe, M, 2023) |
| "A PPC was defined as pneumonia or acute respiratory distress syndrome within 30 days after surgery." | 1.42 | Serum Transforming Growth Factor-β1 Change After Neoadjuvant Chemoradiation Therapy Is Associated With Postoperative Pulmonary Complications in Esophageal Cancer Patients Undergoing Combined Modality Therapy. ( Chang, DT; Cheng, JC; Hsu, CH; Hsu, FM; Huang, PM; Koong, AC; Lee, JM; Lu, SL; Tsai, CL; Wu, JK, 2015) |
| "Squamous cell carcinoma was an adverse factor related to increased postoperative pulmonary complications." | 1.36 | High-dose preoperative chemoradiotherapy in esophageal cancer patients does not increase postoperative pulmonary complications: correlation with dose-volume histogram parameters. ( Hurmuzlu, M; Muren, LP; Smaaland, R; Viste, A; Wentzel-Larsen, T; Øvrebø, K, 2010) |
| "Gemcitabine is a pyrimidine antimetabolite with activity in a number of cancers." | 1.35 | Gemcitabine-induced pulmonary toxicity during adjuvant therapy in a patient with pancreatic cancer. ( Cornfeld, D; Lansigan, F; Saif, MW; Shaib, W; Syrigos, K, 2008) |
| "Data from 110 esophageal cancer patients treated between January 1998 and December 2003 were analyzed retrospectively." | 1.33 | Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery. ( Ajani, JA; Cox, JD; Komaki, R; Liao, Z; Liu, H; Swisher, S; Tucker, SL; Vaporciyan, AA; Wang, SL; Wei, X, 2006) |
| "Fluorouracil-induced pneumonitis was subsequently diagnosed." | 1.30 | [A case of fluorouracil-induced pneumonitis]. ( Andou, H; Itoh, K; Tsuda, T, 1997) |
| " Preoperative chemoradiotherapy consisted of cisplatinum combined chemotherapy and radiotherapy (total dosage of 30-70 Gy)." | 1.30 | Analysis of postoperative complications after esophagectomy for esophageal cancer in patients receiving neoadjuvant therapy. ( Eguchi, R; Hayashi, K; Ide, H; Itoh, H; Nakamura, T; Ohta, M; Okamoto, F; Takasaki, K, 1999) |
| "Seventeen patients with metastatic breast carcinoma were treated with a combination of 5-fluorouracil, methotrexate, vincristine, cyclophosphamide and prednisone." | 1.25 | Nonbacterial pneumonitis with multidrug antineoplastic therapy in breast carcinoma. ( Blom, J; Stutz, FH; Tormey, DC, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (27.27) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuda, S | 1 |
| Kitagawa, Y | 1 |
| Okui, J | 1 |
| Okamura, A | 1 |
| Kawakubo, H | 1 |
| Takemura, R | 1 |
| Muto, M | 1 |
| Kakeji, Y | 1 |
| Takeuchi, H | 1 |
| Watanabe, M | 1 |
| Doki, Y | 1 |
| Zhang, Z | 1 |
| Zhang, H | 1 |
| Ohnuma, H | 1 |
| Sato, Y | 1 |
| Hirakawa, M | 1 |
| Okagawa, Y | 1 |
| Osuga, T | 1 |
| Hayashi, T | 1 |
| Sato, T | 1 |
| Miyanishi, K | 1 |
| Kobune, M | 1 |
| Takimoto, R | 1 |
| Sagawa, T | 1 |
| Hori, M | 1 |
| Someya, M | 1 |
| Nakata, K | 1 |
| Sakata, K | 1 |
| Takayama, T | 1 |
| Kato, J | 1 |
| Lu, SL | 1 |
| Hsu, FM | 1 |
| Tsai, CL | 1 |
| Wu, JK | 1 |
| Lee, JM | 1 |
| Huang, PM | 1 |
| Hsu, CH | 1 |
| Koong, AC | 1 |
| Chang, DT | 1 |
| Cheng, JC | 1 |
| Zhang, P | 1 |
| Xi, M | 1 |
| Li, QQ | 1 |
| Hu, YH | 1 |
| Guo, X | 1 |
| Zhao, L | 1 |
| Liu, H | 2 |
| Liu, SL | 1 |
| Luo, LL | 1 |
| Liu, Q | 1 |
| Liu, MZ | 1 |
| Shaib, W | 1 |
| Lansigan, F | 1 |
| Cornfeld, D | 1 |
| Syrigos, K | 1 |
| Saif, MW | 1 |
| Dähn, D | 1 |
| Martell, J | 1 |
| Vorwerk, H | 1 |
| Hess, CF | 1 |
| Becker, H | 1 |
| Jung, K | 1 |
| Hilgers, R | 1 |
| Wolff, HA | 1 |
| Hermann, RM | 1 |
| Christiansen, H | 1 |
| Hurmuzlu, M | 1 |
| Øvrebø, K | 1 |
| Wentzel-Larsen, T | 1 |
| Muren, LP | 1 |
| Viste, A | 1 |
| Smaaland, R | 1 |
| Yu, TK | 1 |
| Whitman, GJ | 1 |
| Thames, HD | 1 |
| Buzdar, AU | 1 |
| Strom, EA | 1 |
| Perkins, GH | 1 |
| Schechter, NR | 1 |
| McNeese, MD | 1 |
| Kau, SW | 1 |
| Thomas, ES | 1 |
| Hortobagyi, GN | 1 |
| Buchholz, TA | 1 |
| Hirano, A | 1 |
| Tanimoto, Y | 1 |
| Kimura, G | 1 |
| Kiura, K | 1 |
| Ueoka, H | 1 |
| Kataoka, M | 1 |
| Tanimoto, M | 1 |
| Wang, SL | 1 |
| Liao, Z | 1 |
| Vaporciyan, AA | 1 |
| Tucker, SL | 1 |
| Wei, X | 1 |
| Swisher, S | 1 |
| Ajani, JA | 1 |
| Cox, JD | 1 |
| Komaki, R | 1 |
| Lee, DH | 1 |
| Han, JY | 1 |
| Yoon, SM | 1 |
| Lee, JJ | 1 |
| Lee, HG | 1 |
| Kim, HY | 1 |
| Yoon, SJ | 1 |
| Hong, EK | 1 |
| Lee, JS | 1 |
| Andou, H | 1 |
| Itoh, K | 1 |
| Tsuda, T | 1 |
| Eguchi, R | 1 |
| Ide, H | 1 |
| Nakamura, T | 1 |
| Hayashi, K | 1 |
| Ohta, M | 1 |
| Okamoto, F | 1 |
| Itoh, H | 1 |
| Takasaki, K | 1 |
| Doddoli, C | 1 |
| Thomas, P | 1 |
| Reynaud-Gaubert, M | 1 |
| Giudicelli, R | 1 |
| Papazian, L | 1 |
| Fuentes, P | 1 |
| Samuels, ML | 1 |
| Holoye, PY | 1 |
| Johnson, DE | 1 |
| Manheimer, F | 1 |
| Aranda, CP | 1 |
| Smith, RL | 1 |
| Lokich, J | 1 |
| Chaffey, J | 1 |
| Neptune, W | 1 |
| Tallósy, I | 1 |
| Vargha, G | 1 |
| Pölöskey, A | 1 |
| Nagy, Z | 1 |
| Kricskovits, A | 1 |
| Stutz, FH | 2 |
| Blom, J | 2 |
| Tormey, DC | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intensity Modulated Radiation Therapy for Breast Cancer: A Phase I Feasibility Study[NCT00594477] | Phase 1 | 100 participants (Actual) | Interventional | 2008-01-04 | Completed | ||
| A Phase II Trial of Dose Escalated Proton Beam Therapy or Photon Therapy for Resectable and Unresectable Esophageal Cancer[NCT03234842] | Phase 2 | 0 participants (Actual) | Interventional | 2017-10-30 | Withdrawn (stopped due to non-accrual) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for fluorouracil and Pneumonia
| Article | Year |
|---|---|
Impact of neoadjuvant chemotherapy and chemoradiotherapy on postoperative cardiopulmonary complications in patients with esophageal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Adjuvant; Cisplatin; | 2017 |
A Phase 1/2 Study of Definitive Chemoradiation Therapy Using Docetaxel, Nedaplatin, and 5-Fluorouracil (DNF-R) for Esophageal Cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Disease-Free Survival; Doce | 2015 |
Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan | 2004 |
A pilot trial of gemcitabine and vinorelbine plus capecitabine in locally advanced or metastatic nonsmall cell lung cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Car | 2006 |
Concomitant 5-fluorouracil infusion and high-dose radiation for stage III non-small cell lung cancer.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Combined Modality Therapy; Esophagit | 1989 |
17 other studies available for fluorouracil and Pneumonia
| Article | Year |
|---|---|
Old age and intense chemotherapy exacerbate negative prognostic impact of postoperative complication on survival in patients with esophageal cancer who received neoadjuvant therapy: a nationwide study from 85 Japanese esophageal centers.
Topics: Aged; Anastomotic Leak; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; East A | 2023 |
Serum Transforming Growth Factor-β1 Change After Neoadjuvant Chemoradiation Therapy Is Associated With Postoperative Pulmonary Complications in Esophageal Cancer Patients Undergoing Combined Modality Therapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bridged-Ring Compoun | 2015 |
Concurrent cisplatin and 5-fluorouracil versus concurrent cisplatin and docetaxel with radiotherapy for esophageal squamous cell carcinoma: a propensity score-matched analysis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe | 2016 |
Gemcitabine-induced pulmonary toxicity during adjuvant therapy in a patient with pancreatic cancer.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Capecitabine; Chemotherapy, Adjuvant; Deoxycy | 2008 |
Influence of irradiated lung volumes on perioperative morbidity and mortality in patients after neoadjuvant radiochemotherapy for esophageal cancer.
Topics: Acute Lung Injury; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplat | 2010 |
High-dose preoperative chemoradiotherapy in esophageal cancer patients does not increase postoperative pulmonary complications: correlation with dose-volume histogram parameters.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chi-Square Di | 2010 |
[A case of pneumonitis induced by CDDP and 5-FU].
Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamid | 2005 |
Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery.
Topics: Analysis of Variance; Camptothecin; Combined Modality Therapy; Esophageal Neoplasms; Female; Fluorou | 2006 |
[A case of fluorouracil-induced pneumonitis].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Drug Hypersensitivity; Fluorouracil; Hu | 1997 |
Analysis of postoperative complications after esophagectomy for esophageal cancer in patients receiving neoadjuvant therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Esophageal Neoplasms; Esophagectomy; Fluo | 1999 |
[Postoperative complications after radiochemotherapy or chemotherapy for bronchial cancers].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bronchial Fistula; Carcinoma, Bronchoge | 2000 |
Bleomycin combination chemotherapy in the management of testicular neoplasia.
Topics: Abdominal Neoplasms; Adult; Bleomycin; Cyclophosphamide; Drug Therapy, Combination; Dysgerminoma; Fl | 1975 |
Necrotizing pneumonitis caused by 5-fluorouracil infusion. A complication of a Hickman catheter.
Topics: Aged; Brachiocephalic Veins; Catheters, Indwelling; Fluorouracil; Foreign-Body Migration; Humans; In | 1992 |
[Analysis of alveolitis (pneumonitis) as a complication of cytostatic (CMF) therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fluorour | 1987 |
Case 6-1985: progressive pneumonitis after chemotherapy for breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fluorour | 1985 |
Combination chemotherapy in disseminated carcinoma of the breast.
Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Evaluation Stu | 1974 |
Nonbacterial pneumonitis with multidrug antineoplastic therapy in breast carcinoma.
Topics: Adenocarcinoma; Adrenalectomy; Adult; Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Huma | 1973 |