fluorouracil has been researched along with Pleural Effusion in 30 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Pleural Effusion: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 69-year-old woman presented with arterial hypotension, pulmonary oedema and a severely depressed left ventricular ejection fraction (LVEF) of 25% only 3 days after having received her first treatment for colorectal cancer with 5-fluorouracil (5-FU)-based therapy." | 7.83 | 5-Fluorouracil-induced acute reversible heart failure not explained by coronary spasms, myocarditis or takotsubo: lessons from MRI. ( Dalsgaard, M; Fakhri, Y; Lav Madsen, P; Nielsen, D, 2016) |
| "The pharmacokinetic of 5-Fluorouracil and its permeation into malignant pleural effusion was investigated in 9 patients with breast carcinoma who received 600 mg/m2 5-Fluorouracil i." | 7.67 | [Pharmacokinetics of 5-fluorouracil and its permeation in pleural effusions in the therapy of metastatic breast cancer]. ( Wagner, T, 1984) |
| "A 69-year-old woman presented with arterial hypotension, pulmonary oedema and a severely depressed left ventricular ejection fraction (LVEF) of 25% only 3 days after having received her first treatment for colorectal cancer with 5-fluorouracil (5-FU)-based therapy." | 3.83 | 5-Fluorouracil-induced acute reversible heart failure not explained by coronary spasms, myocarditis or takotsubo: lessons from MRI. ( Dalsgaard, M; Fakhri, Y; Lav Madsen, P; Nielsen, D, 2016) |
| "The pharmacokinetic of 5-Fluorouracil and its permeation into malignant pleural effusion was investigated in 9 patients with breast carcinoma who received 600 mg/m2 5-Fluorouracil i." | 3.67 | [Pharmacokinetics of 5-fluorouracil and its permeation in pleural effusions in the therapy of metastatic breast cancer]. ( Wagner, T, 1984) |
| "The management of breast cancer during pregnancy is a challenge for physicians due to mother´s desire to carry the pregnancy to term despite the need for chemotherapy." | 1.62 | [Chemotherapy for breast cancer during pregnancy: about a case]. ( Andrianandrasana, NO; Rafaramino, F; Rakotomalala, HM; Ramahandrisoa, AVN; Razakanaivo, M, 2021) |
| " Five cardiopulmonary toxic events of Grade 3 or greater were observed in 4 patients, Grade 5 heart failure and Grade 3 pericarditis in 1 patient, and Grade 3 myocardial infarction, Grade 3 radiation pneumonitis, and Grade 3 pleural effusion." | 1.35 | Late toxicity after definitive concurrent chemoradiotherapy for thoracic esophageal carcinoma. ( Chin, K; Gomi, K; Ito, H; Kozuka, T; Matsuura, M; Morota, M; Oguchi, M; Yamashita, T, 2009) |
| "Surgery was performed for sigmoid colon cancer on September 29, 2004." | 1.34 | [A patient with recurrent sigmoid colon cancer in whom pleural effusion and ascites resolved after FOLFOX 4 therapy]. ( Akamatsu, M; Katamoto, T; Matsubara, S; Nakata, W; Ohata, K; Ohmae, T; Tsuji, Y, 2007) |
| "We describe a 56-year-old woman with breast cancer who received adjuvant chemotherapy after a breast-preserving surgical procedure." | 1.33 | Intrapleural extravasation of epirubicin, 5-fluouracil, and cyclophosphamide, treated with dexrazoxane. ( Brouwer, RE; Uges, JW; Vollaard, AM; Wilms, EB, 2006) |
| "A pleural effusion is a frequent complication of malignant disease." | 1.26 | Management of malignant pleural effusion. ( Bennett, JM; Greenwald, DW; Phillips, C, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (63.33) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Rakotomalala, HM | 1 |
| Ramahandrisoa, AVN | 1 |
| Razakanaivo, M | 1 |
| Andrianandrasana, NO | 1 |
| Rafaramino, F | 1 |
| Fakhri, Y | 1 |
| Dalsgaard, M | 1 |
| Nielsen, D | 1 |
| Lav Madsen, P | 1 |
| Morota, M | 1 |
| Gomi, K | 1 |
| Kozuka, T | 1 |
| Chin, K | 1 |
| Matsuura, M | 1 |
| Oguchi, M | 1 |
| Ito, H | 1 |
| Yamashita, T | 1 |
| Dähn, D | 1 |
| Martell, J | 1 |
| Vorwerk, H | 1 |
| Hess, CF | 1 |
| Becker, H | 1 |
| Jung, K | 1 |
| Hilgers, R | 1 |
| Wolff, HA | 1 |
| Hermann, RM | 1 |
| Christiansen, H | 1 |
| MRAZEK, RG | 1 |
| STREHL, FW | 1 |
| SOUTHWICK, HW | 1 |
| SUHRLAND, LG | 1 |
| WEISBERGER, AS | 1 |
| Gupta, D | 1 |
| Ross, K | 1 |
| Piacentino, V | 1 |
| Stepnowski, D | 1 |
| McClurken, JB | 1 |
| Furukawa, S | 1 |
| Dempsey, DT | 1 |
| Sagara, H | 1 |
| Okayama, H | 1 |
| Ohtake, T | 1 |
| Yasuda, M | 1 |
| Watanabe, K | 1 |
| Takenoshita, S | 1 |
| Uges, JW | 1 |
| Vollaard, AM | 1 |
| Wilms, EB | 1 |
| Brouwer, RE | 1 |
| Akamatsu, M | 1 |
| Tsuji, Y | 1 |
| Nakata, W | 1 |
| Ohmae, T | 1 |
| Ohata, K | 1 |
| Matsubara, S | 1 |
| Katamoto, T | 1 |
| Wagner, T | 1 |
| Valet, G | 1 |
| Warnecke, HH | 1 |
| Kahle, H | 1 |
| Scholz, J | 1 |
| Steinhöfel, U | 1 |
| Dürig, M | 1 |
| Prause, A | 1 |
| Bause, HW | 1 |
| Hamper, K | 1 |
| Schulte am Esch, J | 1 |
| Athanassiadou, P | 1 |
| Athanassiades, P | 1 |
| Petrakakou, E | 1 |
| Zerva, C | 1 |
| Mavrikakis, M | 1 |
| Greenwald, DW | 1 |
| Phillips, C | 1 |
| Bennett, JM | 1 |
| Jamieson, GG | 1 |
| Angove, RC | 1 |
| Onadeko, BO | 1 |
| Degner, RA | 1 |
| Kerley, SW | 1 |
| McGregor, DH | 1 |
| Dixon, AY | 1 |
| Markman, M | 1 |
| Apple, JS | 1 |
| Paulson, DF | 1 |
| Baber, C | 1 |
| Putman, CE | 1 |
| Ito, M | 1 |
| Taki, T | 1 |
| Reshad, K | 1 |
| Ninomiya, K | 1 |
| Ikeda, S | 1 |
| Asakura, H | 1 |
| Champeau, M | 1 |
| Arsac, M | 1 |
| Pineau, P | 1 |
| Faulkner, SL | 1 |
| Adkins, RB | 1 |
| Reynolds, VH | 1 |
| Umhauer, I | 1 |
| Boesen, EA | 1 |
| Lewis, GC | 1 |
| Perlia, CP | 1 |
| Donegan, WL | 1 |
| Manzur, R | 1 |
| Oliva Otero, G | 1 |
| Tano Assini, MT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Individual Radiosensitivity of Cancer Patients to be Treated by Radiotherapy or Radiochemotherapy Per-operative[NCT02797405] | 97 participants (Actual) | Interventional | 2016-10-31 | Terminated (stopped due to Withdrawal of analysis study Partner.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Pleural Effusion
| Article | Year |
|---|---|
Intracavitary chemotherapy.
Topics: Absorption; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascitic | 1985 |
Chemotherapy of bronchial carcinoma.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Blood Cell Count; Bone Marrow Diseases; Bronchial N | 1973 |
1 trial available for fluorouracil and Pleural Effusion
| Article | Year |
|---|---|
Postoperative pulmonary complications in patients with esophageal cancer.
Topics: Aged; Brachytherapy; Chi-Square Distribution; Cisplatin; Combined Modality Therapy; Esophageal Neopl | 1993 |
27 other studies available for fluorouracil and Pleural Effusion
| Article | Year |
|---|---|
[Chemotherapy for breast cancer during pregnancy: about a case].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubici | 2021 |
5-Fluorouracil-induced acute reversible heart failure not explained by coronary spasms, myocarditis or takotsubo: lessons from MRI.
Topics: Aged; Colorectal Neoplasms; Coronary Angiography; Diagnosis, Differential; Echocardiography; Female; | 2016 |
Late toxicity after definitive concurrent chemoradiotherapy for thoracic esophageal carcinoma.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squ | 2009 |
Influence of irradiated lung volumes on perioperative morbidity and mortality in patients after neoadjuvant radiochemotherapy for esophageal cancer.
Topics: Acute Lung Injury; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplat | 2010 |
CHEMOTHERAPY FOR CANCER.
Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Exudates and Transuda | 1964 |
INTRACAVITARY 5-FLUOROURACIL IN MALIGNANT EFFUSIONS.
Topics: Antimetabolites; Fluorouracil; Humans; Infusions, Parenteral; Neoplasm Metastasis; Neoplasms; Perica | 1965 |
Use of LeVeen pleuroperitoneal shunt for refractory high-volume chylothorax.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Chylothorax; | 2004 |
[A patient with metastatic breast cancer associated with retention of pleural effusion with no response to both CMF and exemestane, whose life was saved by high-dose toremifene].
Topics: Aged; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocol | 2005 |
Intrapleural extravasation of epirubicin, 5-fluouracil, and cyclophosphamide, treated with dexrazoxane.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosp | 2006 |
[A patient with recurrent sigmoid colon cancer in whom pleural effusion and ascites resolved after FOLFOX 4 therapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Ascites; Fluorouracil; Humans; Leuco | 2007 |
[Pharmacokinetics of 5-fluorouracil and its permeation in pleural effusions in the therapy of metastatic breast cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Breast Neoplasms; Chr | 1984 |
New possibilities of cytostatic drug testing on patient tumor cells by flow cytometry.
Topics: Antineoplastic Agents; Ascitic Fluid; Cell Survival; Cells, Cultured; Cisplatin; Cyclophosphamide; D | 1984 |
Immunocytochemical detection of P-glycoprotein in the management of malignant effusions.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Ascitic Fluid; ATP Binding Cassette | 1997 |
Management of malignant pleural effusion.
Topics: Bleomycin; Fluorouracil; Gold Radioisotopes; Humans; Mechlorethamine; Methods; Neoplasms; Phosphorus | 1978 |
Heparinized chemotherapy in the treatment of disseminated lung cancer.
Topics: Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouraci | 1979 |
The intrapleural instillation of nitrogen mustard and 5-fluorouracil in the management of malignant pleural effusions in Nigerians.
Topics: Adolescent; Adult; Aged; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Mechlorethamine; Middle | 1978 |
Metastatic basal cell carcinoma: report of a case presenting with respiratory failure.
Topics: Carcinoma, Basal Cell; Female; Fluorouracil; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Neopla | 1991 |
Advanced prostatic carcinoma: pulmonary manifestations.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Fluorouracil; Hum | 1985 |
[Studies on the pleural permeability of carmofur].
Topics: Administration, Oral; Fluorouracil; Humans; Neoplasms; Permeability; Pleural Effusion | 1987 |
[Treatment of malignant pleural effusions by intracavitary injection of mixture of 5FU, cyclophosphamide, mitomycin C, bleomycin and thioinosine].
Topics: Adult; Aged; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Cyclophosphamid | 1973 |
[Primary cancer of the liver in a child detected by angiography and treated by exeresis and antimitotics].
Topics: Adolescent; Angiography; Carcinoma, Hepatocellular; Cholangiography; Diagnosis, Differential; Echino | 1968 |
Chemotherapy for adenocarcinoma and alveolar cell carcinoma of the lung.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Adult; Female; Fluorouracil; Follow-Up Studies; | 1974 |
[Results of polycytostatic therapy in tumorous pleural effusion (author's transl)].
Topics: Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Me | 1974 |
Gynecologic oncology.
Topics: Alkylating Agents; Ascites; Biopsy; Dactinomycin; Endometrium; Female; Fluorouracil; Genital Neoplas | 1973 |
The problems of drug treatment of breast cancer.
Topics: Age Factors; Alkylating Agents; Androgens; Bone Neoplasms; Breast Neoplasms; Corticosterone; Drug Co | 1973 |
Cancer of the breast. Endocrine ablation, hormone therapy and chemotherapy.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Adult; Age Factors; Breast Neoplasms; Castration; Dyspnea; F | 1967 |
[Effect of antineoplastic drug therapy in the management of tumor cells of pleural and ascitic effusion].
Topics: Ascites; Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Humans; Mesothelioma; Mustard Com | 1970 |