fluorouracil has been researched along with Pleural Effusion, Malignant in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Pleural Effusion, Malignant: Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histologically diffuse-type gastric cancer is well known to have a poor prognosis and is often complicated with abdominal and pleural effusions." | 2.72 | A phase II study of combined chemotherapy with methotrexate, 5-fluorouracil, and low-dose cisplatin (MFP) for histologically diffuse-type advanced and recurrent gastric cancer (KDOG9501). ( Koizumi, W; Nakayama, N; Saigenji, K; Sasaki, T; Tanabe, S, 2006) |
| "In a responding patient with advanced breast cancer, pre-treatment total TS protein was 130 fmol/mg and the TS activity was 3." | 1.29 | [Pharmacological and biochemical investigation of intracavital fluorinated pyrimidine chemotherapy]. ( Aiba, K; Horikoshi, N; Ito, Y; Kasumi, F; Mihara, H; Ohta, H; Shibata, H; Takahashi, S; Takahashi, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zarogoulidis, P | 1 |
| Chatzaki, E | 1 |
| Hohenforst-Schmidt, W | 1 |
| Goldberg, EP | 1 |
| Galaktidou, G | 1 |
| Kontakiotis, T | 1 |
| Karamanos, N | 1 |
| Zarogoulidis, K | 1 |
| Mori, K | 1 |
| Chiba, N | 1 |
| Yamamoto, Y | 1 |
| Yonekawa, H | 1 |
| Nakayama, N | 1 |
| Koizumi, W | 1 |
| Tanabe, S | 1 |
| Sasaki, T | 1 |
| Saigenji, K | 1 |
| Suzuki, M | 1 |
| Shibata, H | 1 |
| Aiba, K | 1 |
| Mihara, H | 1 |
| Ito, Y | 1 |
| Takahashi, S | 1 |
| Horikoshi, N | 1 |
| Kasumi, F | 1 |
| Ohta, H | 1 |
| Takahashi, T | 1 |
| Ishikawa, A | 1 |
| Matsuura, M | 1 |
| Nakajima, N | 1 |
| Ozawa, M | 1 |
| Matsuda, M | 1 |
| Ito, K | 1 |
| Suzuki, K | 1 |
| Toyama, K | 1 |
| Bonnefoi, H | 1 |
| Smith, IE | 1 |
| Fujita, A | 1 |
| Takabatake, H | 1 |
| Tagaki, S | 1 |
| Sekine, K | 1 |
| Fujitake, S | 1 |
| Maeda, Y | 1 |
| Shimizu, M | 1 |
| Nozaki, H | 1 |
| Tohyama, M | 1 |
| Kataoka, S | 1 |
| Shoji, T | 1 |
| Tanaka, F | 1 |
| Yanagihara, K | 1 |
| Inui, K | 1 |
| Wada, H | 1 |
1 review available for fluorouracil and Pleural Effusion, Malignant
| Article | Year |
|---|---|
Management of malignant pleural effusion by suicide gene therapy in advanced stage lung cancer: a case series and literature review.
Topics: Adenoviridae; Aged; Anemia; Animals; Antimetabolites, Antineoplastic; Bystander Effect; Carcinoma, N | 2012 |
2 trials available for fluorouracil and Pleural Effusion, Malignant
| Article | Year |
|---|---|
A phase II study of combined chemotherapy with methotrexate, 5-fluorouracil, and low-dose cisplatin (MFP) for histologically diffuse-type advanced and recurrent gastric cancer (KDOG9501).
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisp | 2006 |
Phase II study of repeated intrapleural chemotherapy using implantable access system for management of malignant pleural effusion.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorour | 2002 |
7 other studies available for fluorouracil and Pleural Effusion, Malignant
| Article | Year |
|---|---|
[A case of recurrent breast cancer with carcinomatous pleurisy successfully treated with combined chemoendocrine-therapy of CTF (CPA, THP and 5-FU) and anastrozole following instillation therapy 12 years after radical mastectomy].
Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carci | 2002 |
[A patient with advanced breast cancer refractory to chemotherapy accompanied by carcinomatous pleurisy and multiple bone metastasis that responded to combination therapy with high-dose toremifene and docetaxel].
Topics: Aged; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplas | 2007 |
[Pharmacological and biochemical investigation of intracavital fluorinated pyrimidine chemotherapy].
Topics: Aged; Antimetabolites, Antineoplastic; Ascitic Fluid; Breast Neoplasms; Female; Fluorouracil; Humans | 1995 |
[Advanced breast cancer with onset of multi-organ metastases successfully treated with combined loco-regional therapies: a case report].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Ch | 1993 |
How should cancer presenting as a malignant pleural effusion be managed?
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bronchoscopy; Carcinoma; Cisplatin; Epi | 1996 |
[Efficacy of systemic chemotherapy in adenocarcinoma of the lung with pleuritis carcinomatosa].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin | 1997 |
[A case of giant advanced breast cancer responding remarkably to chemo-endocrine therapy chiefly with doxifluridine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, D | 1998 |