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fluorouracil and Plasma Cell Tumor

fluorouracil has been researched along with Plasma Cell Tumor in 19 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"We reported previously that treatment of mice bearing MOPC-315 plasmacytoma with the drugs L-PAM (phenylalanine mustard) or 5-FU (5-fluorouracil), in combination with low doses of THF-gamma 2, was more effective in increasing their survival time than treatment with the drug alone."3.68Therapeutic effectiveness against MOPC-315 plasmacytoma of low or high doses of the synthetic thymic hormone THF-gamma 2 in combination with an "immunomodulating" or a "non-immunomodulating" drug. ( Ben-Efraim, S; Burstein, Y; Harshemesh, H; Ophir, R; Pecht, M; Trainin, N, 1991)
" In the present study the therapeutic effect and metabolism of 5-FU and its masked compounds: FT, UFT (uracil + FT), HCFU (Carmofur), 5'-DFUR (Doxifluridine) were assessed by using MOPC-104E plasmacytoma transplanted subcutaneously in BALB/c mice with CCl4-induced chronic liver dysfunction."3.68[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction]. ( Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M, 1990)
"Mice BDF1 with L 1210 or mice BALB/c with plasmacytoma MOPS-406 after pretreatment with ineffective doses of 1-beta-D-ribofuranosyl-4-methylmercaptopyrazolo(3,4-d)pyramidin e (25 to 100 mg/kg per 5 days) were treated with 5-fluorouracil at the optimal dose 100 mg per day."3.67[Enhanced antitumor action of 5-fluorouracil when used in combination with 4-methylmercaptopyrazolo[3,4-d]pyrimidine 1-nucleoside]. ( Garin, AM; Korbukh, IA; Lobova, TG; Preobrazhenskaia, MN, 1988)
" 5-FU oral bioavailability was approximately 100% in rats pretreated with 5-EU."1.295-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil. ( Baccanari, DP; Davis, ST; Knick, VC; Spector, T, 1993)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199015 (78.95)18.7374
1990's4 (21.05)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abraham, D2
Carbone, PP2
Venditti, JM1
Kline, I1
Goldin, A1
Teller, MN4
Faanes, RB1
Citarella, RV1
Wallace, RE1
Murdock, KC1
Angier, RB1
Durr, FE1
Forbes, M1
Baccanari, DP1
Davis, ST1
Knick, VC1
Spector, T1
Volm, M2
Faufmann, M1
MAttern, J2
Wayss, K2
Ophir, R3
Pecht, M2
Burstein, Y2
Harshemesh, H1
Ben-Efraim, S4
Trainin, N2
Tsubono, M2
Nio, Y3
Imai, S3
Shiraishi, T3
Morimoto, H2
Tseng, CC2
Kawabata, K1
Fukumoto, M1
Tobe, T3
Ohgaki, K1
Halperin, D1
Rashid, G1
Shoval, S2
Lobova, TG1
Korbukh, IA1
Preobrazhenskaia, MN1
Garin, AM1
de Clercq, E1
Wand, H1
Rieche, K1
Everson, R1
Kessel, D1
Hall, TC1
Bowie, M3
Mountain, IM1
Stock, CC2

Other Studies

19 other studies available for fluorouracil and Plasma Cell Tumor

ArticleYear
Evaluation of chemical agents against the plasma cell tumor LPC-1 in mice.
    Biochemical pharmacology, 1967, Volume: 16, Issue:4

    Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cyclophosphamide; Electrophoresis; Fluorouracil;

1967
Association of host immunity with 5-fluorouracil-initiated cure of plasmacytoma LPC-1 in BALB/c mice.
    Cancer research, 1980, Volume: 40, Issue:8 Pt 1

    Topics: Animals; Antigens, Neoplasm; Cytotoxicity, Immunologic; Fluorouracil; Immunity, Cellular; Mice; Mice

1980
Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice.
    Cancer research, 1982, Volume: 42, Issue:2

    Topics: Animals; Anthracenes; Antineoplastic Agents; Doxorubicin; Drug Administration Schedule; Drug Evaluat

1982
5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Dec-01, Volume: 90, Issue:23

    Topics: Administration, Oral; Animals; Biological Availability; Colonic Neoplasms; Dihydrouracil Dehydrogena

1993
Sensitivity tests of tumors to cytostatic agents. I. Comparative investigations on transplanted tumors in vivo and in vitro.
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1975, Volume: 83, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Division; Cricetinae; Da

1975
Therapeutic effectiveness against MOPC-315 plasmacytoma of low or high doses of the synthetic thymic hormone THF-gamma 2 in combination with an "immunomodulating" or a "non-immunomodulating" drug.
    International journal of cancer, 1991, Apr-22, Volume: 48, Issue:1

    Topics: Animals; Cell Line; Combined Modality Therapy; Dose-Response Relationship, Drug; Fluorouracil; Immun

1991
Low uracil concentration in the liver might be responsible for the decreased antineoplastic activity of fluoropyrimidines in mice with CCl4-induced chronic liver dysfunction.
    Oncology, 1991, Volume: 48, Issue:3

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Resistance; Fi

1991
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
    Nihon Gan Chiryo Gakkai shi, 1990, Mar-20, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride

1990
Lymphocytes anticancer chemosensitivity testing in vitro--an approach to predict immunosuppressive effect of anticancer agents.
    Journal of clinical & laboratory immunology, 1989, Volume: 29, Issue:3

    Topics: Animals; Antineoplastic Agents; Carbazilquinone; Doxorubicin; Fluorouracil; Immunosuppressive Agents

1989
THF-gamma 2, a thymic hormone, increases immunocompetence and survival in 5-fluorouracil-treated mice bearing MOPC-315 plasmacytoma.
    Cancer immunology, immunotherapy : CII, 1989, Volume: 30, Issue:2

    Topics: Animals; Antibody Formation; Concanavalin A; Fluorouracil; Immunocompetence; Interleukin-2; Male; Mi

1989
The difference between 5-fluorouracil and melphalan in their ability to promote antitumor immune response against MOPC-315 plasmacytoma.
    Cancer immunology, immunotherapy : CII, 1986, Volume: 22, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Concanavalin A; Cytotoxicity, Immunologic; Fluorouracil; Lymphocyte

1986
[Enhanced antitumor action of 5-fluorouracil when used in combination with 4-methylmercaptopyrazolo[3,4-d]pyrimidine 1-nucleoside].
    Eksperimental'naia onkologiia, 1988, Volume: 10, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Eval

1988
Enhancing effect of bromovinyldeoxyuridine on antitumour activity of 5-fluorouracil in mice bearing MOPC-315 plasmacytomas.
    British journal of cancer, 1986, Volume: 54, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Dose-Response Relationsh

1986
[The effect of cytostatic drugs on blood platelets and lymphocytes in patients with neoplasms].
    Folia haematologica (Leipzig, Germany : 1928), 1974, Volume: 101, Issue:5

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Amidines; Antibiotics, Antineoplastic; Bleomycin; Blood

1974
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
    Biochemical pharmacology, 1970, Volume: 19, Issue:11

    Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; N

1970
The effects of cytostatic drugs on transplanted tumours. An investigation of the correlation between in vivo and in vitro results.
    Archiv fur Geschwulstforschung, 1974, Volume: 43, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Cytarabine; Dauno

1974
Combination chemotherapy of advanced murine myeloma and subsequent resistance to tumor cell challenge.
    Journal of the National Cancer Institute, 1974, Volume: 52, Issue:3

    Topics: Allyl Compounds; Aniline Compounds; Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy,

1974
Plasma cell tumors in experimental chemotherapy: consequence of dose variation on host survival and paraprotein synthesis.
    Journal of the National Cancer Institute, 1970, Volume: 45, Issue:6

    Topics: Aniline Compounds; Animals; Blood Protein Disorders; Blood Protein Electrophoresis; Bloodletting; Cy

1970
Transplantable mouse plasma cell tumors in experimental chemotherapy.
    Journal of the National Cancer Institute, 1969, Volume: 43, Issue:1

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Blood Protein Electrophoresis; Blood Proteins; Ch

1969