fluorouracil has been researched along with Pituitary Neoplasms in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5T) was performed in 191 female CMF (Cyclophosphamide, Methotrexate, 5-Fluorouracil) chemotherapy-exposed breast cancer survivors." | 3.77 | Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy. ( Boogerd, W; Breteler, MM; Koppelmans, V; Poels, MM; Schagen, SB; Seynaeve, C; van der Lugt, A, 2011) |
| "However, the presence of metastases separate from the pituitary in the central nervous system or at a distance is necessary to designate pituitary tumors as carcinomas, i." | 1.30 | The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors. ( Besser, GM; Grossman, AB; Kaltsas, GA; Monson, JP; Mukherjee, JJ; Plowman, PN, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| AbdelBaki, MS | 1 |
| Waguespack, SG | 1 |
| Salceda, V | 1 |
| Jones, J | 1 |
| Stapleton, SL | 1 |
| Baskin, DS | 1 |
| Okcu, MF | 1 |
| Lundgren, JA | 1 |
| Oldfield, EH | 1 |
| Marshall, JC | 1 |
| Koppelmans, V | 1 |
| Schagen, SB | 1 |
| Poels, MM | 1 |
| Boogerd, W | 1 |
| Seynaeve, C | 1 |
| van der Lugt, A | 1 |
| Breteler, MM | 1 |
| Lin, CS | 1 |
| Lin, SH | 1 |
| Chiang, YH | 1 |
| Sheu, LF | 1 |
| Chao, TY | 1 |
| Ferguson, T | 1 |
| Kaltsas, GA | 1 |
| Mukherjee, JJ | 1 |
| Plowman, PN | 1 |
| Monson, JP | 1 |
| Grossman, AB | 1 |
| Besser, GM | 1 |
| Lamberts, SW | 1 |
| van Koetsveld, P | 1 |
| Hofland, LJ | 1 |
| Wilson, CB | 1 |
| Winternitz, WW | 1 |
| Rush, BF | 1 |
| Walton, KN | 1 |
| Maddy, JA | 1 |
1 review available for fluorouracil and Pituitary Neoplasms
| Article | Year |
|---|---|
Significant response of pituitary carcinoma to carboplatin, leucovorin and fluorouracil chemotherapy: a pediatric case report and review of the literature.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carc | 2017 |
7 other studies available for fluorouracil and Pituitary Neoplasms
| Article | Year |
|---|---|
The longest stalk: preserved pituitary function after regression of a giant prolactinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Fluorouracil; Humans; M | 2017 |
Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brea | 2011 |
Diabetes insipidus revealing an isolated pituitary stalk metastasis of breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; | 2007 |
Prevention and delay of spontaneous mammary and pituitary tumors by long- and short-term ingestion of 5-fluorouracil in Wistar-Furth rats.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluoro | 1980 |
The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined C | 1998 |
The interrelationship between the anti-mitotic action of the somatostatin analog octreotide and that of cytostatic drugs and suramin.
Topics: Animals; Antineoplastic Agents; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Int | 1991 |
Cryohypophysectomy: indications, technic, and results.
Topics: Acromegaly; Adenoma, Chromophobe; Adult; Breast Neoplasms; Carcinoma; Castration; Cryosurgery; Cushi | 1967 |