fluorouracil has been researched along with Pink Eye in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have reported that an alternating regimen of bolus and continuous infusion 5-fluorouracil (FU) was superior to bolus FU in terms of response rate and progression-free survival in advanced colorectal cancer." | 9.09 | 5-fluorouracil modulated by leucovorin, methotrexate and mitomycin: highly effective, low-cost chemotherapy for advanced colorectal cancer. ( Aschele, C; Caroti, C; Cirillo, M; Cortesi, E; Frassineti, GL; Gallo, L; Grossi, F; Guglielmi, A; Labianca, R; Pessi, MA; Ravaioli, A; Recaldin, E; Sobrero, A; Testore, P; Turci, D, 2001) |
| "Ocular toxicity derived from the use of systemic fluorouracil has been widely described in the literature, as well as the relationship between the use of capecitabine and the appearance of conjunctivitis." | 8.12 | Conjunctivitis associated with capecitabine treatment in a patient with colon cancer: The importance on educating patients into identifying adverse reactions. ( Bello Crespo, M; Gajete Pablos, MA; Gioseffi, HA; Roa García, DM; Trujillano Ruiz, A, 2022) |
| "Escalating doses of cyclophosphamide were given every 3 weeks as adjuvant treatment for women operated for breast cancer to determine the maximum tolerated dose of cyclophosphamide that can be given with constant doses of methotrexate (40 mg/m2) and 5-FU (600 mg/m2; CMF) as an outpatient treatment without the routine use of granulocyte colony-stimulating growth factor (G-CSF)." | 7.70 | Intensified adjuvant cyclophosphamide, methotrexate and 5-fluorouracil therapy: a dose-finding study for ambulatory patients with breast cancer. ( Hietanen, P; Joensuu, H; Teerenhovi, L, 1999) |
| "We have reported that an alternating regimen of bolus and continuous infusion 5-fluorouracil (FU) was superior to bolus FU in terms of response rate and progression-free survival in advanced colorectal cancer." | 5.09 | 5-fluorouracil modulated by leucovorin, methotrexate and mitomycin: highly effective, low-cost chemotherapy for advanced colorectal cancer. ( Aschele, C; Caroti, C; Cirillo, M; Cortesi, E; Frassineti, GL; Gallo, L; Grossi, F; Guglielmi, A; Labianca, R; Pessi, MA; Ravaioli, A; Recaldin, E; Sobrero, A; Testore, P; Turci, D, 2001) |
| "148 patients with advanced untreated colorectal cancer were randomised to receive a weekly bolus of 5-fluorouracil (5-FU) 600 mg/m2 alone, with or without leucovorin (LV) 500 mg/m2." | 5.07 | Randomised comparison of weekly bolus 5-fluorouracil with or without leucovorin in metastatic colorectal carcinoma. ( Canobbio, L; Fassio, T; Gallo, L; Guglielmi, A; Nobile, MT; Rosso, R; Rubagotti, A; Sertoli, MR; Venturini, M; Vidili, MG, 1992) |
| "Ocular toxicity derived from the use of systemic fluorouracil has been widely described in the literature, as well as the relationship between the use of capecitabine and the appearance of conjunctivitis." | 4.12 | Conjunctivitis associated with capecitabine treatment in a patient with colon cancer: The importance on educating patients into identifying adverse reactions. ( Bello Crespo, M; Gajete Pablos, MA; Gioseffi, HA; Roa García, DM; Trujillano Ruiz, A, 2022) |
| "Escalating doses of cyclophosphamide were given every 3 weeks as adjuvant treatment for women operated for breast cancer to determine the maximum tolerated dose of cyclophosphamide that can be given with constant doses of methotrexate (40 mg/m2) and 5-FU (600 mg/m2; CMF) as an outpatient treatment without the routine use of granulocyte colony-stimulating growth factor (G-CSF)." | 3.70 | Intensified adjuvant cyclophosphamide, methotrexate and 5-fluorouracil therapy: a dose-finding study for ambulatory patients with breast cancer. ( Hietanen, P; Joensuu, H; Teerenhovi, L, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Bello Crespo, M | 1 |
| Trujillano Ruiz, A | 1 |
| Gajete Pablos, MA | 1 |
| Roa García, DM | 1 |
| Gioseffi, HA | 1 |
| Bruckner, HW | 1 |
| Cohen, J | 1 |
| Loprinzi, CL | 2 |
| Wender, DB | 1 |
| Veeder, MH | 1 |
| O'Fallon, JR | 1 |
| Vaught, NL | 1 |
| Dose, AM | 1 |
| Ghosh, C | 1 |
| Bartel, J | 1 |
| Leitch, JM | 1 |
| Hietanen, P | 1 |
| Teerenhovi, L | 1 |
| Joensuu, H | 1 |
| Sobrero, A | 2 |
| Zaniboni, A | 1 |
| Frassineti, GL | 2 |
| Aschele, C | 2 |
| Guglielmi, A | 3 |
| Giuliani, R | 1 |
| Ravaioli, A | 2 |
| Lanfranco, C | 1 |
| Caroti, C | 2 |
| Arnoldi, E | 1 |
| Barni, S | 1 |
| Gallo, L | 3 |
| Pessi, MA | 2 |
| Turci, D | 2 |
| Cortesi, E | 2 |
| Grossi, F | 2 |
| Frontini, L | 1 |
| Piazza, E | 1 |
| Bruzzi, P | 1 |
| Labianca, R | 2 |
| Cirillo, M | 1 |
| Recaldin, E | 1 |
| Testore, P | 1 |
| Miyamoto, K | 1 |
| Tanaka, T | 1 |
| Isawa, S | 1 |
| Yamashita, T | 1 |
| Matsuda, A | 1 |
| Nobile, MT | 1 |
| Rosso, R | 1 |
| Sertoli, MR | 1 |
| Rubagotti, A | 1 |
| Vidili, MG | 1 |
| Venturini, M | 1 |
| Canobbio, L | 1 |
| Fassio, T | 1 |
| Finkelstein, I | 1 |
| Trope, GE | 1 |
| Heathcote, JG | 1 |
| Rootman, DS | 1 |
| Spero, L | 1 |
| Menon, IA | 1 |
| Love, RR | 1 |
| Garrity, JA | 1 |
| Ames, MM | 1 |
| Rosenoff, SH | 1 |
| Wolf, ML | 1 |
| Chabner, BA | 1 |
4 trials available for fluorouracil and Pink Eye
| Article | Year |
|---|---|
Inhibition of 5-fluorouracil-induced ocular irritation by ocular ice packs.
Topics: Conjunctivitis; Cryotherapy; Eye; Female; Fluorouracil; Humans; Ice; Male; Middle Aged | 1994 |
Schedule specific biochemical modulation of 5-fluorouracil in advanced colorectal cancer: a randomized study. GISCAD, IOR and collaborating centers.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colore | 2000 |
5-fluorouracil modulated by leucovorin, methotrexate and mitomycin: highly effective, low-cost chemotherapy for advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Conjunctivitis; D | 2001 |
Randomised comparison of weekly bolus 5-fluorouracil with or without leucovorin in metastatic colorectal carcinoma.
Topics: Adult; Aged; Colorectal Neoplasms; Conjunctivitis; Diarrhea; Drug Administration Schedule; Female; F | 1992 |
7 other studies available for fluorouracil and Pink Eye
| Article | Year |
|---|---|
Conjunctivitis associated with capecitabine treatment in a patient with colon cancer: The importance on educating patients into identifying adverse reactions.
Topics: Aged, 80 and over; Capecitabine; Colonic Neoplasms; Conjunctivitis; Fluorouracil; Humans; Male; Rect | 2022 |
MTX/5-FU trials in gastrointestinal and other cancers.
Topics: Aged; Anemia; Conjunctivitis; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Gastrointest | 1983 |
Intensified adjuvant cyclophosphamide, methotrexate and 5-fluorouracil therapy: a dose-finding study for ambulatory patients with breast cancer.
Topics: Adult; Aged; Agranulocytosis; Alopecia; Ambulatory Care; Antineoplastic Combined Chemotherapy Protoc | 1999 |
[Toxicological studies of bleomycin ointment. Irritative effect of bleomycin ointment on eye mucous membrane and skin (author's transl)].
Topics: Administration, Topical; Animals; Bleomycin; Conjunctiva; Conjunctivitis; Cornea; Erythema; Eye; Eye | 1975 |
Further evaluation of collagen shields as a delivery system for 5-fluorouracil: histopathological observations.
Topics: Animals; Biological Dressings; Collagen; Conjunctiva; Conjunctivitis; Connective Tissue; Drug Carrie | 1991 |
Cyclophosphamide, methotrexate, and 5-fluorouracil (CMF)-induced ocular toxicity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Conjunctivitis; Cromolyn Sodium; Drug Adm | 1990 |
Pseudomonas blepharoconjunctivitis: a complication of combination chemotherapy.
Topics: Antineoplastic Agents; Bacitracin; Blepharitis; Bone Marrow; Breast Neoplasms; Carbenicillin; Cephal | 1974 |