fluorouracil has been researched along with Pericarditis in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Pericarditis: Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced. Pericarditis usually leads to PERICARDIAL EFFUSION, or CONSTRICTIVE PERICARDITIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) has a significant antineoplastic activity and has been used for the management of various malignant neoplasms." | 5.38 | Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. ( Çağdaş, M; Çalık, AN; Çeliker, E; Güzelburç, Ö; Velibey, Y, 2012) |
| "A9 years boy diagnosed with nasopharyngeal carcinoma was started on chemotherapy protocol including 5-fluorouracil." | 3.81 | Chemotherapy Induced Acute Pericarditis in a Child. ( Almoukirish, S; Jadoon, S; Khan, MA; Momenah, TS; Rahman, A, 2015) |
| "The purpose of this study was the evaluation of the effectiveness of intrapericardial administration of tetracycline, 5-fluorouracil and cisplatin in patients with recurrent malignant pericardial effusion." | 3.69 | New approaches to the management and treatment of malignant pericardial effusion. ( Burakowski, J; Fijałkowska, A; Filipecki, S; Szturmowicz, M; Tomkowski, W, 1997) |
| " Patients are now surviving long enough for the adverse cardiovascular effects of some cancer therapies to become apparent." | 2.44 | Chemotherapy and cardiotoxicity. ( Broder, H; Gottlieb, RA; Lepor, NE, 2008) |
| "5-Fluorouracil (5-FU) has a significant antineoplastic activity and has been used for the management of various malignant neoplasms." | 1.38 | Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. ( Çağdaş, M; Çalık, AN; Çeliker, E; Güzelburç, Ö; Velibey, Y, 2012) |
| " Five cardiopulmonary toxic events of Grade 3 or greater were observed in 4 patients, Grade 5 heart failure and Grade 3 pericarditis in 1 patient, and Grade 3 myocardial infarction, Grade 3 radiation pneumonitis, and Grade 3 pleural effusion." | 1.35 | Late toxicity after definitive concurrent chemoradiotherapy for thoracic esophageal carcinoma. ( Chin, K; Gomi, K; Ito, H; Kozuka, T; Matsuura, M; Morota, M; Oguchi, M; Yamashita, T, 2009) |
| "Pericarditis and cardiac arrhythmias developed, but the patient did not have cardiac tamponade." | 1.28 | Intrapericardial infusion of 5-fluorouracil. An unusual complication of a Hickman catheter. ( Cathcart-Rake, WF; Mowery, WE, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, MA | 1 |
| Rahman, A | 1 |
| Almoukirish, S | 1 |
| Jadoon, S | 1 |
| Momenah, TS | 1 |
| Broder, H | 1 |
| Gottlieb, RA | 1 |
| Lepor, NE | 1 |
| Morota, M | 1 |
| Gomi, K | 1 |
| Kozuka, T | 1 |
| Chin, K | 1 |
| Matsuura, M | 1 |
| Oguchi, M | 1 |
| Ito, H | 2 |
| Yamashita, T | 1 |
| Çalık, AN | 1 |
| Çeliker, E | 1 |
| Velibey, Y | 1 |
| Çağdaş, M | 1 |
| Güzelburç, Ö | 1 |
| Killu, A | 1 |
| Madhavan, M | 1 |
| Prasad, K | 1 |
| Prasad, A | 1 |
| Inanç, M | 1 |
| Akpek, M | 1 |
| Inanç, MT | 1 |
| Kaya, MG | 1 |
| Kumekawa, Y | 1 |
| Kaneko, K | 1 |
| Kurahashi, T | 1 |
| Konishi, K | 1 |
| Katagiri, A | 1 |
| Yamamoto, T | 1 |
| Kuwahara, M | 1 |
| Kubota, Y | 1 |
| Muramoto, T | 1 |
| Mizutani, Y | 1 |
| Imawari, M | 1 |
| Antonelli, D | 1 |
| Beker, B | 1 |
| Barzilay, J | 1 |
| Tomkowski, W | 1 |
| Szturmowicz, M | 1 |
| Fijałkowska, A | 1 |
| Burakowski, J | 1 |
| Filipecki, S | 1 |
| Cathcart-Rake, WF | 1 |
| Mowery, WE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Individual Radiosensitivity of Cancer Patients to be Treated by Radiotherapy or Radiochemotherapy Per-operative[NCT02797405] | 97 participants (Actual) | Interventional | 2016-10-31 | Terminated (stopped due to Withdrawal of analysis study Partner.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Pericarditis
| Article | Year |
|---|---|
Chemotherapy and cardiotoxicity.
Topics: Age of Onset; Anthracyclines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplas | 2008 |
9 other studies available for fluorouracil and Pericarditis
| Article | Year |
|---|---|
Chemotherapy Induced Acute Pericarditis in a Child.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protoco | 2015 |
Late toxicity after definitive concurrent chemoradiotherapy for thoracic esophageal carcinoma.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squ | 2009 |
Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis.
Topics: Acute Disease; Adenocarcinoma; Antimetabolites, Antineoplastic; Colonic Neoplasms; Coronary Angiogra | 2012 |
5-fluorouracil induced pericarditis.
Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Diagnosis, Differential; Fluorouracil; Humans; M | 2011 |
Acute pericarditis during 5-fluorouracil, docetaxel and cisplatin therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Coronary Angiography; Fluorouracil; Human | 2012 |
Late toxicity in complete response cases after definitive chemoradiotherapy for esophageal squamous cell carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Esophagea | 2006 |
[Early cardiotoxicity of 5-fluorouracil].
Topics: Adenocarcinoma; Colonic Neoplasms; Fluorouracil; Humans; Male; Middle Aged; Myocarditis; Pericarditi | 1981 |
New approaches to the management and treatment of malignant pericardial effusion.
Topics: Adult; Aged; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineop | 1997 |
Intrapericardial infusion of 5-fluorouracil. An unusual complication of a Hickman catheter.
Topics: Adenocarcinoma; Arrhythmias, Cardiac; Catheterization, Central Venous; Colonic Neoplasms; Female; Fl | 1991 |