fluorouracil has been researched along with Paget Disease, Extramammary in 34 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Paget Disease, Extramammary: A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to treat a patient with extramammary Paget's disease who had multiple metastases, 500 mg/day of 5-fluorouracil (7 days per week) and 5 mg/day of cisplatin (5 days per week) were administrated intravenously for 24 hours and 1 hour, respectively." | 3.72 | Trial of low-dose 5-fluorouracil/cisplatin therapy for advanced extramammary Paget's disease. ( Kariya, K; Schwartz, RA; Tsuji, T, 2004) |
| "Advanced extramammary Paget's disease is also adenocarcinoma of the skin." | 2.40 | [Chemotherapy for advanced adenocarcinoma of the skin: experience with combination chemotherapy and a review of the literature]. ( Yamazaki, N, 1997) |
| "A patient was diagnosed by biopsy and treated for squamous cell carcinoma in situ of the scrotum." | 2.38 | Paget's disease of the scrotum: a case report and review of current literature. ( Boman, DA; Dudrey, EF; Moliver, CL; Morales, CA; Reedy, MB, 1991) |
| "Although topical therapies are used to treat extramammary Paget's disease (EMPD), reliable treatment outcomes and the effects of these therapies on subsequent surgical treatments are unclear." | 1.62 | Initial topical monotherapy may increase the risk of recurrence in patients with extramammary Paget's disease. ( Choi, S; Chung, KY; Oh, BH; Oh, Y; Roh, MR, 2021) |
| "Anal canal cancer occasionally accompanies extramammary Paget disease." | 1.48 | Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report. ( Hirose, S; Hyodo, I; Kawai, H; Moriwaki, T; Sato, M; Suganuma, D; Tajima, H; Uchida, Y; Watanabe, R; Yamada, T; Yamamoto, Y; Yamaura, M, 2018) |
| "Metastatic penoscrotal extramammary Paget's disease (EMPD) has seldom been reported in the literature." | 1.35 | Clinicopathological characteristics, management and outcome of metastatic penoscrotal extramammary Paget's disease. ( Dai, B; Mao, HR; Shen, YJ; Yao, XD; Ye, DW; Zhang, HL; Zhang, SL; Zhu, Y, 2009) |
| "Skin biopsy confirmed the diagnosis of extramammary Paget's disease, and a CT scan revealed multiple metastases to the lymph nodes along the iliac artery and aorta." | 1.31 | Docetaxel induced durable response in advanced extramammary Paget's disease: a case report. ( Kaneko, M; Oguchi, S; Saida, T; Uhara, H, 2002) |
| "The true extent of the skin affected in extramammary Paget's disease is frequently well beyond its clinical borders." | 1.27 | Role of preoperative topical 5-fluorouracil in preparation for Mohs micrographic surgery of extramammary Paget's disease. ( Eliezri, YD; Horan, DB; Silvers, DN, 1987) |
| "A case of extramammary Paget's disease is reported." | 1.27 | Metastatic extramammary Paget's disease: dramatic response to combined modality treatment. ( Athar, M; Balducci, L; Crawford, ED; Khansur, T; McKenzie, D; Smith, GF, 1988) |
| "In a 74-year-old man extramammary Paget's disease of the scrotal and perianal areas masqueraded as tinea cruris and chronic dermatitis for 7 years before it was diagnosed." | 1.26 | Extramammary Paget's disease. ( Goodall, J; Haberman, HF; Llewellyn, M, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (26.47) | 18.7374 |
| 1990's | 6 (17.65) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 7 (20.59) | 24.3611 |
| 2020's | 4 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Wada, S | 1 |
| Ogata, D | 1 |
| Nakano, E | 1 |
| Namikawa, K | 3 |
| Yamazaki, N | 4 |
| Nakamura, K | 1 |
| Nakamura, M | 2 |
| Kato, H | 2 |
| Morita, A | 2 |
| Choi, S | 1 |
| Oh, Y | 1 |
| Roh, MR | 1 |
| Chung, KY | 1 |
| Oh, BH | 1 |
| Watanabe, S | 1 |
| Kariya, K | 2 |
| Pittman, ME | 1 |
| Milsom, J | 1 |
| Yantiss, RK | 1 |
| Yamaura, M | 1 |
| Yamada, T | 2 |
| Watanabe, R | 1 |
| Kawai, H | 1 |
| Hirose, S | 1 |
| Tajima, H | 1 |
| Sato, M | 1 |
| Uchida, Y | 1 |
| Suganuma, D | 1 |
| Yamamoto, Y | 2 |
| Moriwaki, T | 1 |
| Hyodo, I | 1 |
| Molina, GE | 1 |
| Khalifian, S | 1 |
| Mull, JL | 1 |
| Chen, L | 1 |
| Rosman, IS | 1 |
| Faulkner-Jones, BE | 1 |
| Ngo, KH | 1 |
| Demehri, S | 1 |
| Cornelius, LA | 1 |
| Wu, PA | 1 |
| Tsutsui, K | 1 |
| Takahashi, A | 1 |
| Oashi, K | 1 |
| Tsutsumida, A | 1 |
| Tanaka, R | 1 |
| Omata, W | 1 |
| Tokuda, Y | 1 |
| Arakura, F | 1 |
| Uhara, H | 2 |
| Zhu, Y | 1 |
| Ye, DW | 1 |
| Yao, XD | 1 |
| Zhang, SL | 1 |
| Dai, B | 1 |
| Zhang, HL | 1 |
| Shen, YJ | 1 |
| Mao, HR | 1 |
| Brightman, L | 1 |
| Warycha, M | 1 |
| Anolik, R | 1 |
| Geronemus, R | 1 |
| Onishi, I | 1 |
| Kamata, T | 1 |
| Hayashi, H | 1 |
| Hayashi, Y | 1 |
| Minatoya, G | 1 |
| Michiwa, Y | 1 |
| Takeda, T | 1 |
| Kanno, M | 1 |
| Takeda, K | 1 |
| Tsuji, T | 1 |
| Schwartz, RA | 1 |
| Ye, JN | 1 |
| Rhew, DC | 1 |
| Yip, F | 1 |
| Edelstein, L | 1 |
| Arensmeier, M | 1 |
| Theuring, U | 1 |
| Franke, I | 1 |
| Willgeroth, C | 1 |
| Kühne, KH | 1 |
| Bewley, AP | 1 |
| Bracka, A | 1 |
| Staughton, RC | 1 |
| Bunker, CB | 1 |
| Del Castillo, LF | 1 |
| Garcia, C | 1 |
| Schoendorff, C | 1 |
| Garcia, JF | 1 |
| Torres, LM | 1 |
| Garcia Almagro, D | 1 |
| Brown, RS | 1 |
| McCormack, M | 1 |
| Lankester, KJ | 1 |
| Spittle, MF | 1 |
| Khoubehi, B | 1 |
| Schofield, A | 1 |
| Leslie, M | 1 |
| Slevin, ML | 1 |
| Talbot, IC | 1 |
| Northover, JM | 1 |
| Oguchi, S | 1 |
| Kaneko, M | 1 |
| Saida, T | 1 |
| Miki, Y | 2 |
| Kawatsu, T | 2 |
| Matsuda, H | 1 |
| Kahata, A | 1 |
| Kaufman, RH | 1 |
| Haberman, HF | 1 |
| Goodall, J | 1 |
| Llewellyn, M | 1 |
| Voigt, H | 1 |
| Bassermann, R | 1 |
| Nathrath, W | 1 |
| Reedy, MB | 1 |
| Morales, CA | 1 |
| Moliver, CL | 1 |
| Dudrey, EF | 1 |
| Boman, DA | 1 |
| Thirlby, RC | 1 |
| Hammer, CJ | 1 |
| Galagan, KA | 1 |
| Travaglini, JJ | 1 |
| Picozzi, VJ | 1 |
| Eliezri, YD | 1 |
| Silvers, DN | 1 |
| Horan, DB | 1 |
| Balducci, L | 1 |
| Athar, M | 1 |
| Smith, GF | 1 |
| Khansur, T | 1 |
| McKenzie, D | 1 |
| Crawford, ED | 1 |
| Tjandra, J | 1 |
| Sillman, FH | 1 |
| Sedlis, A | 1 |
| Boyce, JG | 1 |
| Fetherston, WC | 1 |
| Friedrich, EG | 1 |
6 reviews available for fluorouracil and Paget Disease, Extramammary
| Article | Year |
|---|---|
Do lasers or topicals really work for nonmelanoma skin cancers?
Topics: Administration, Cutaneous; Aminoquinolines; Antimetabolites, Antineoplastic; Antineoplastic Agents; | 2011 |
Extramammary Paget's disease resistant to surgery and imiquimod monotherapy but responsive to imiquimod combination topical chemotherapy with 5-fluorouracil and retinoic acid: a case report.
Topics: Administration, Cutaneous; Aged; Aminoquinolines; Antineoplastic Combined Chemotherapy Protocols; Di | 2006 |
[Chemotherapy for advanced adenocarcinoma of the skin: experience with combination chemotherapy and a review of the literature].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Drug Administration Sch | 1997 |
Intraepithelial carcinoma of the vulva.
Topics: Carcinoma in Situ; Carcinoma, Squamous Cell; Diagnosis, Differential; Female; Fluorouracil; Humans; | 1977 |
Paget's disease of the scrotum: a case report and review of current literature.
Topics: Carcinoma in Situ; Carcinoma, Squamous Cell; Combined Modality Therapy; Fluorouracil; Genital Neopla | 1991 |
A review of lower genital intraepithelial neoplasia and the use of topical 5-fluorouracil.
Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Adult; Anal Canal; Anus Neoplasms; Carc | 1985 |
28 other studies available for fluorouracil and Paget Disease, Extramammary
| Article | Year |
|---|---|
Efficacy of chemotherapies for unresectable extramammary Paget disease: a single-centre retrospective study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Docetaxel; Fluorouracil; Humans; Paget | 2023 |
Low-dose 5-fluorouracil/cisplatin therapy as conversion chemotherapy for advanced extramammary Paget's disease.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; F | 2020 |
Initial topical monotherapy may increase the risk of recurrence in patients with extramammary Paget's disease.
Topics: Fluorouracil; Humans; Imiquimod; Neoplasm Recurrence, Local; Paget Disease, Extramammary; Retrospect | 2021 |
Efficacy of low-dose 5-fluorouracil/cisplatin therapy for invasive extramammary Paget's disease.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; | 2018 |
Treatment Effects Can Mimic Recurrent Extramammary Paget Disease in Perianal Skin.
Topics: Administration, Cutaneous; Antimetabolites, Antineoplastic; Anus Neoplasms; Biomarkers, Tumor; Biops | 2018 |
Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report.
Topics: Adenocarcinoma; Aged; Anal Canal; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Ca | 2018 |
Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease.
Topics: Administration, Topical; Aged; Antineoplastic Combined Chemotherapy Protocols; Calcitriol; Female; F | 2019 |
Advanced extramammary Paget disease treated with neoadjuvant chemotherapy: A report of two cases.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Epirubicin; Fl | 2020 |
Combination chemotherapy for metastatic extramammary Paget disease.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Bone Neopla | 2014 |
Combination chemotherapy of low-dose 5-fluorouracil and cisplatin for advanced extramammary Paget's disease.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; | 2015 |
Clinicopathological characteristics, management and outcome of metastatic penoscrotal extramammary Paget's disease.
Topics: Aged; Antineoplastic Agents; Biomarkers, Tumor; Cadherins; Docetaxel; Female; Fluorouracil; Genital | 2009 |
[A case of vulval extramammary Paget's disease associated with pancreatic cancer that was successfully treated with chemotherapy].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; D | 2002 |
Trial of low-dose 5-fluorouracil/cisplatin therapy for advanced extramammary Paget's disease.
Topics: Aged; Antineoplastic Agents; Cisplatin; Fatal Outcome; Fluorouracil; Genital Neoplasms, Male; Humans | 2004 |
[Topical therapy of extramammary Paget's disease].
Topics: Administration, Topical; Aged; Aged, 80 and over; Fluorouracil; Humans; Male; Paget Disease, Extrama | 1994 |
Extramammary Paget's disease of the scrotum: treatment with topical 5-fluorouracil and plastic surgery.
Topics: Aged; Combined Modality Therapy; Fluorouracil; Genital Neoplasms, Male; Humans; Male; Paget Disease, | 1994 |
Spontaneous apparent clinical resolution with histologic persistence of a case of extramammary Paget's disease: response to topical 5-fluorouracil.
Topics: Administration, Topical; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Female; Fluoroura | 2000 |
Spontaneous apparent clinical resolution with histologic persistence of a case of extramammary Paget's disease: response to topical 5-fluorouracil.
Topics: Anus Neoplasms; Dose Fractionation, Radiation; Female; Fluorouracil; Follow-Up Studies; Humans; Neop | 2000 |
Metastatic in-situ perianal Paget's disease.
Topics: Abdomen; Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Cisplatin; Fluorourac | 2001 |
Docetaxel induced durable response in advanced extramammary Paget's disease: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Administration Schedule; | 2002 |
[Topical chemotherapy for carcinoma of the skin (author's transl)].
Topics: Administration, Topical; Adolescent; Aged; Bleomycin; Bowen's Disease; Carcinoma, Basal Cell; Carcin | 1975 |
Extramammary Paget's disease.
Topics: Aged; Anus Neoplasms; Fluorouracil; Genital Neoplasms, Male; Humans; Male; Paget Disease, Extramamma | 1978 |
Cytoreductive combination chemotherapy for regionally advanced unresectable extramammary Paget carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Fluorouracil; Humans; Immunohisto | 1992 |
Perianal Paget's disease: successful treatment with combined chemoradiotherapy. Report of a case.
Topics: Aged; Anus Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Male; Mitomycin; Mitomycins; | 1990 |
Role of preoperative topical 5-fluorouracil in preparation for Mohs micrographic surgery of extramammary Paget's disease.
Topics: Aged; Biopsy; Fluorouracil; Genital Neoplasms, Male; Humans; Male; Paget Disease, Extramammary; Preo | 1987 |
Metastatic extramammary Paget's disease: dramatic response to combined modality treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluorouracil; Humans; Lym | 1988 |
Perianal Paget's disease. Report of three cases.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Anus Neoplasms; Female; Fluorouracil; Humans; Male; Neoplas | 1988 |
Triple extramammary Paget's disease.
Topics: Aged; Axilla; Fluorouracil; Humans; Male; Neoplasms, Multiple Primary; Paget Disease, Extramammary; | 1971 |
The origin and significance of vulvar Paget's disease.
Topics: Aged; Female; Fluorouracil; Humans; Microscopy, Electron; Middle Aged; Neoplasm Recurrence, Local; P | 1972 |