fluorouracil has been researched along with Overweight in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Overweight: A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal over fat.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obesity and underweight status were associated independently with inferior outcomes in patients with colon cancer who received treatment in adjuvant chemotherapy trials." | 2.78 | Body mass index at diagnosis and survival among colon cancer patients enrolled in clinical trials of adjuvant chemotherapy. ( Benson, A; Degramont, A; Foster, NR; Goldberg, RM; Labianca, R; O'Connell, MJ; Sargent, DJ; Seitz, JF; Sinicrope, FA; Yothers, G, 2013) |
| " We have previously demonstrated that by means of a comprehensive dietary modification which aims at lowering insulin levels it is possible to reduce body weight and decrease the bioavailability of insulin, sex hormones and the growth factors linked to BC risk and prognosis." | 2.77 | Preventing weight gain during adjuvant chemotherapy for breast cancer: a dietary intervention study. ( Berrino, F; Bruno, E; Curtosi, P; Evangelista, A; Gargano, G; Morelli, D; Pasanisi, P; Raimondi, M; Villarini, A, 2012) |
| "Pancreatic cancer is the fourth leading cause of cancer death in the United States." | 2.45 | Medical management of pancreatic adenocarcinoma. ( Cunha, JE; Fernandes, Gdos S; Freitas, D; Hoff, PM, 2009) |
| "Obesity is associated with an increased risk of colon cancer." | 1.36 | Obesity is an independent prognostic variable in colon cancer survivors. ( Foster, NR; O'Connell, MJ; Rankin, C; Sargent, DJ; Sinicrope, FA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Freitas, D | 1 |
| Fernandes, Gdos S | 1 |
| Hoff, PM | 1 |
| Cunha, JE | 1 |
| Sinicrope, FA | 2 |
| Foster, NR | 2 |
| Sargent, DJ | 2 |
| O'Connell, MJ | 2 |
| Rankin, C | 1 |
| Villarini, A | 1 |
| Pasanisi, P | 1 |
| Raimondi, M | 1 |
| Gargano, G | 1 |
| Bruno, E | 1 |
| Morelli, D | 1 |
| Evangelista, A | 1 |
| Curtosi, P | 1 |
| Berrino, F | 1 |
| Yothers, G | 1 |
| Benson, A | 1 |
| Seitz, JF | 1 |
| Labianca, R | 1 |
| Goldberg, RM | 1 |
| Degramont, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Impact of a Moderate CAlorie and Protein REstriction PROgram (CARE-PRO) as an Efficient and Affordable Therapeutic Strategy in Patients With Barrett's Esophagus.[NCT03813381] | 160 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Overweight
| Article | Year |
|---|---|
Medical management of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Aging; Antineoplastic Agents; Black People; Capecitabine; Deoxycytidine; Diabe | 2009 |
2 trials available for fluorouracil and Overweight
| Article | Year |
|---|---|
Preventing weight gain during adjuvant chemotherapy for breast cancer: a dietary intervention study.
Topics: Adult; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, | 2012 |
Body mass index at diagnosis and survival among colon cancer patients enrolled in clinical trials of adjuvant chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Chemotherapy, Adjuvant; Colonic Neo | 2013 |
1 other study available for fluorouracil and Overweight
| Article | Year |
|---|---|
Obesity is an independent prognostic variable in colon cancer survivors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Body Composition; Body | 2010 |