Page last updated: 2024-10-27

fluorouracil and Overweight

fluorouracil has been researched along with Overweight in 4 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Overweight: A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal over fat.

Research Excerpts

ExcerptRelevanceReference
"Obesity and underweight status were associated independently with inferior outcomes in patients with colon cancer who received treatment in adjuvant chemotherapy trials."2.78Body mass index at diagnosis and survival among colon cancer patients enrolled in clinical trials of adjuvant chemotherapy. ( Benson, A; Degramont, A; Foster, NR; Goldberg, RM; Labianca, R; O'Connell, MJ; Sargent, DJ; Seitz, JF; Sinicrope, FA; Yothers, G, 2013)
" We have previously demonstrated that by means of a comprehensive dietary modification which aims at lowering insulin levels it is possible to reduce body weight and decrease the bioavailability of insulin, sex hormones and the growth factors linked to BC risk and prognosis."2.77Preventing weight gain during adjuvant chemotherapy for breast cancer: a dietary intervention study. ( Berrino, F; Bruno, E; Curtosi, P; Evangelista, A; Gargano, G; Morelli, D; Pasanisi, P; Raimondi, M; Villarini, A, 2012)
"Pancreatic cancer is the fourth leading cause of cancer death in the United States."2.45Medical management of pancreatic adenocarcinoma. ( Cunha, JE; Fernandes, Gdos S; Freitas, D; Hoff, PM, 2009)
"Obesity is associated with an increased risk of colon cancer."1.36Obesity is an independent prognostic variable in colon cancer survivors. ( Foster, NR; O'Connell, MJ; Rankin, C; Sargent, DJ; Sinicrope, FA, 2010)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Freitas, D1
Fernandes, Gdos S1
Hoff, PM1
Cunha, JE1
Sinicrope, FA2
Foster, NR2
Sargent, DJ2
O'Connell, MJ2
Rankin, C1
Villarini, A1
Pasanisi, P1
Raimondi, M1
Gargano, G1
Bruno, E1
Morelli, D1
Evangelista, A1
Curtosi, P1
Berrino, F1
Yothers, G1
Benson, A1
Seitz, JF1
Labianca, R1
Goldberg, RM1
Degramont, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Impact of a Moderate CAlorie and Protein REstriction PROgram (CARE-PRO) as an Efficient and Affordable Therapeutic Strategy in Patients With Barrett's Esophagus.[NCT03813381]160 participants (Actual)Interventional2015-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and Overweight

ArticleYear
Medical management of pancreatic adenocarcinoma.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2009, Volume: 9, Issue:3

    Topics: Adenocarcinoma; Aged; Aging; Antineoplastic Agents; Black People; Capecitabine; Deoxycytidine; Diabe

2009

Trials

2 trials available for fluorouracil and Overweight

ArticleYear
Preventing weight gain during adjuvant chemotherapy for breast cancer: a dietary intervention study.
    Breast cancer research and treatment, 2012, Volume: 135, Issue:2

    Topics: Adult; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma,

2012
Body mass index at diagnosis and survival among colon cancer patients enrolled in clinical trials of adjuvant chemotherapy.
    Cancer, 2013, Apr-15, Volume: 119, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Chemotherapy, Adjuvant; Colonic Neo

2013

Other Studies

1 other study available for fluorouracil and Overweight

ArticleYear
Obesity is an independent prognostic variable in colon cancer survivors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Mar-15, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Body Composition; Body

2010