fluorouracil has been researched along with Osteoporosis in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osteoprotegerin (OPG) acts as a decoy receptor for RANK, interrupting osteoclast activation and bone resorption." | 5.42 | Association of osteoprotegerin and bone loss after adjuvant chemotherapy in early-stage breast cancer. ( Lustberg, MB; Oostra, DR; Pan, X; Reinbolt, RE; Shapiro, CL; Wesolowski, R, 2015) |
| "Osteoporosis is of concern in breast cancer patients who are undergoing chemotherapy." | 2.75 | Combination of radiological and biochemical methods to assess bone mineral density of mandible in fully edentulous patients after chemotherapy: a 5-year prospective study. ( Cheung, MN; Chow, LW; Jin, LJ; Loo, WT; Wang, M, 2010) |
| "Osteoprotegerin (OPG) acts as a decoy receptor for RANK, interrupting osteoclast activation and bone resorption." | 1.42 | Association of osteoprotegerin and bone loss after adjuvant chemotherapy in early-stage breast cancer. ( Lustberg, MB; Oostra, DR; Pan, X; Reinbolt, RE; Shapiro, CL; Wesolowski, R, 2015) |
| "Hyporexia/anorexia is a relevant clinical problem affecting the quality of life of many cancer patients." | 1.37 | Steroids, cancer and vertebral fractures: a dreaded combination. ( Uña Cidón, E, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oostra, DR | 1 |
| Lustberg, MB | 1 |
| Reinbolt, RE | 1 |
| Pan, X | 1 |
| Wesolowski, R | 1 |
| Shapiro, CL | 1 |
| Loo, WT | 1 |
| Jin, LJ | 1 |
| Cheung, MN | 1 |
| Chow, LW | 1 |
| Wang, M | 1 |
| Uña Cidón, E | 1 |
| Leśniewski-Kmak, K | 1 |
| Zieliński, KW | 1 |
| Szczylik, C | 1 |
| Bruning, PF | 1 |
| Pit, MJ | 1 |
| de Jong-Bakker, M | 1 |
| van den Ende, A | 1 |
| Hart, A | 1 |
| van Enk, A | 1 |
1 trial available for fluorouracil and Osteoporosis
| Article | Year |
|---|---|
Combination of radiological and biochemical methods to assess bone mineral density of mandible in fully edentulous patients after chemotherapy: a 5-year prospective study.
Topics: Absorptiometry, Photon; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Bone Res | 2010 |
4 other studies available for fluorouracil and Osteoporosis
| Article | Year |
|---|---|
Association of osteoprotegerin and bone loss after adjuvant chemotherapy in early-stage breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyc | 2015 |
Steroids, cancer and vertebral fractures: a dreaded combination.
Topics: Adrenal Cortex Hormones; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Capecitabin | 2011 |
Quantitative assessment of the clavicle radiostructure as a tool for estimation of the osteopathic effect of breast cancer chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Diseases; Breas | 2002 |
Bone mineral density after adjuvant chemotherapy for premenopausal breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Breast Neoplasms; Combined Moda | 1990 |