fluorouracil has been researched along with Osteonecrosis in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antiangiogenic monoclonal antibody aflibercept in association with fluorouracil and irinotecan improves the survival of patients with metastatic colorectal cancer (mCRC) treated previously with oxaliplatin-based therapy." | 8.93 | Jaw osteonecrosis associated with aflibercept, irinotecan and fluorouracil: attention to oral district. ( Ciuffreda, L; Fanchini, L; Mecca, C; Pinta, F; Ponzetti, A; Racca, P; Spadi, R; Zanini, M, 2016) |
| "The antiangiogenic monoclonal antibody aflibercept in association with fluorouracil and irinotecan improves the survival of patients with metastatic colorectal cancer (mCRC) treated previously with oxaliplatin-based therapy." | 4.93 | Jaw osteonecrosis associated with aflibercept, irinotecan and fluorouracil: attention to oral district. ( Ciuffreda, L; Fanchini, L; Mecca, C; Pinta, F; Ponzetti, A; Racca, P; Spadi, R; Zanini, M, 2016) |
| "The pathogenesis and treatment of osteonecrosis have not been elucidated." | 1.39 | [A case of osteonecrosis of the jaw during treatment by bevacizumab for sigmoid colon cancer]. ( Ono, F; Onochi, S; Sato, M; Yamamura, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, M | 1 |
| Ono, F | 1 |
| Yamamura, A | 1 |
| Onochi, S | 1 |
| Ponzetti, A | 1 |
| Pinta, F | 1 |
| Spadi, R | 1 |
| Mecca, C | 1 |
| Fanchini, L | 1 |
| Zanini, M | 1 |
| Ciuffreda, L | 1 |
| Racca, P | 1 |
| Obrist, R | 1 |
| Hartmann, D | 1 |
| Obrecht, JP | 1 |
| Marymont, JV | 1 |
| Kaufman, EE | 1 |
1 review available for fluorouracil and Osteonecrosis
| Article | Year |
|---|---|
Jaw osteonecrosis associated with aflibercept, irinotecan and fluorouracil: attention to oral district.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cam | 2016 |
3 other studies available for fluorouracil and Osteonecrosis
| Article | Year |
|---|---|
[A case of osteonecrosis of the jaw during treatment by bevacizumab for sigmoid colon cancer].
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera | 2013 |
Osteonecrosis after chemotherapy.
Topics: Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Humerus | 1978 |
Osteonecrosis of bone associated with combination chemotherapy without corticosteroids.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Non | 1986 |