fluorouracil has been researched along with Osteogenic Sarcoma in 45 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thymoquinone (TMQ) is a pharmacological component of black cumin that has multiple anti-tumorigenic effects." | 5.43 | Anticancer drugs with chemotherapeutic interactions with thymoquinone in osteosarcoma cells. ( Bayram, R; Benek, SB; Sarman, H, 2016) |
| "5-Fluorouracil (5-FU) activity for various carcinomas of adults has been enhanced through the synergistic effect of leucovorin." | 5.07 | Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors. ( Bowman, LC; Douglass, EC; Houghton, JA; Howlett, N; Kun, LE; Meyer, WH; Mounce, K; Poe, D; Pratt, CB, 1994) |
| " We silenced UBXN2A in the human osteosarcoma U2OS cell line, an enriched mortalin cancer cell, followed by a clinical dosage of the chemotherapeutic agent 5-fluorouracil (5-FU)." | 3.83 | Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. ( Abdullah, A; Chauhan, SC; Nelson, ME; Newton, SS; Rezvani, K; Sane, S; Wang, H, 2016) |
| " They had osteosarcoma in methotrexate group (n=7), gastrointestinal malignancies in 5FU group (n=9) and breast cancer in the capecitabine group (n=2)." | 3.78 | Relationship between antimetabolite toxicity and pharmacogenetics in Turkish cancer patients. ( Akbulut, H; Demirkazik, A; Dincol, D; Dogan, M; Icli, F; Karabulut, HG; Tukun, A; Utkan, G; Yalcin, B, 2012) |
| "Eleven patients with osteogenic sarcoma (9), Hodgkin disease (1), and mesenchymal sarcoma (1), were treated with 5-fluorouracil (5-FU) and cisplatin (DDP)." | 3.66 | 5-fluorouracil and cis-platinum in the treatment of refractory solid tumors: a pediatric oncology group phase I-II study. ( Chan, R; Dyment, PG; Land, VJ; Starling, K; Strandjord, SE, 1981) |
| "The potential impact on cancer mortality from these treatment results is obvious." | 2.36 | Multimodal primary cancer treatment (adjuvant chemotherapy): current results and future prospects. ( DeVita, VT; Weiss, RB, 1979) |
| "Thymoquinone (TMQ) is a pharmacological component of black cumin that has multiple anti-tumorigenic effects." | 1.43 | Anticancer drugs with chemotherapeutic interactions with thymoquinone in osteosarcoma cells. ( Bayram, R; Benek, SB; Sarman, H, 2016) |
| "Osteosarcoma is the most common primary malignancy of bone." | 1.40 | Osteopontin upregulates the expression of glucose transporters in osteosarcoma cells. ( Fu, WM; Hsieh, IS; Yang, RS, 2014) |
| "GX15-070 induced autophagy in esophagus cancer cell line EC9706 and osteosarcoma cancer cell line U2OS." | 1.36 | The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells. ( Cao, Q; Chen, Q; Cheng, C; Jin, Y; Pan, J; Verstovsek, S, 2010) |
| " In this report, the effect of LDH intercalated with 5-Fu (5-Fu-LDH) was evaluated in whole animal by studying pharmacokinetic behavior and tissue distribution." | 1.36 | Biocompatible nanoparticles intercalated with anticancer drug for target delivery: pharmacokinetic and biodistribution study. ( Choi, SJ; Choy, JH; Oh, JM, 2010) |
| "In addition, 5FC treatment of bone sarcomas caused a significant reduction in cancer-induced bone destruction (P < 0." | 1.32 | Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. ( Clohisy, DR; Goblirsch, M; Lewis, V; Lynch, C; Mantyh, P; Orchard, P; Pan, W; Ramnaraine, M, 2003) |
| " With use of these studies, a therapeutic ratio (concentration that prevented 25% clonal growth compared to untreated control of bone marrow divided by LD50 of tumor) was calculated for each drug in each tumor." | 1.27 | 5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow. ( Armstrong, RD; Cadman, E, 1983) |
| "Since 1963, regional intra-arterial infusion of anti-cancer agents combined with surgery has been used in the treatment of 56 patients with osteosarcomas." | 1.26 | The results of surgical treatment combined with intra-arterial infusion of anti-cancer agents in osteosarcoma. ( AKAHOSHI, Y; Chen, SH; Kikuike, A; Nishimoto, T; Takeuchi, S; Yamamuro, T; Yonezawa, H, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (51.11) | 18.7374 |
| 1990's | 2 (4.44) | 18.2507 |
| 2000's | 7 (15.56) | 29.6817 |
| 2010's | 10 (22.22) | 24.3611 |
| 2020's | 3 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Witkowska, M | 1 |
| Maciejewska, N | 1 |
| Ryczkowska, M | 1 |
| Olszewski, M | 1 |
| Bagiński, M | 1 |
| Makowiec, S | 1 |
| Sun, J | 1 |
| Wu, W | 1 |
| Tang, X | 1 |
| Zhang, F | 1 |
| Ju, C | 1 |
| Liu, R | 1 |
| Liang, Y | 1 |
| Yu, B | 1 |
| Lv, B | 1 |
| Guo, Y | 2 |
| Zeng, D | 1 |
| Tao, X | 1 |
| Wang, M | 1 |
| Zhang, Z | 1 |
| Zhang, C | 1 |
| Lv, XB | 1 |
| Sergi, CM | 1 |
| Zhao, Y | 1 |
| Xu, K | 1 |
| Liu, P | 1 |
| Spina, A | 1 |
| Sorvillo, L | 1 |
| Chiosi, E | 1 |
| Esposito, A | 1 |
| Di Maiolo, F | 1 |
| Sapio, L | 1 |
| Caraglia, M | 1 |
| Naviglio, S | 1 |
| Hsieh, IS | 1 |
| Yang, RS | 1 |
| Fu, WM | 1 |
| Sane, S | 1 |
| Abdullah, A | 1 |
| Nelson, ME | 1 |
| Wang, H | 1 |
| Chauhan, SC | 1 |
| Newton, SS | 1 |
| Rezvani, K | 1 |
| Sarman, H | 1 |
| Bayram, R | 1 |
| Benek, SB | 1 |
| Scharnweber, T | 1 |
| Santos, C | 1 |
| Franke, RP | 1 |
| Almeida, MM | 1 |
| Costa, ME | 1 |
| Im, YS | 1 |
| Shin, HK | 1 |
| Kim, HR | 1 |
| Jeong, SH | 1 |
| Kim, SR | 1 |
| Kim, YM | 1 |
| Lee, DH | 1 |
| Jeon, SH | 1 |
| Lee, HW | 1 |
| Choi, JK | 1 |
| Song, B | 1 |
| Wang, Y | 1 |
| Xi, Y | 1 |
| Kudo, K | 1 |
| Bruheim, S | 1 |
| Botchkina, GI | 1 |
| Gavin, E | 1 |
| Wan, Y | 1 |
| Formentini, A | 1 |
| Kornmann, M | 1 |
| Fodstad, O | 1 |
| Ju, J | 1 |
| Pan, J | 1 |
| Cheng, C | 1 |
| Verstovsek, S | 1 |
| Chen, Q | 1 |
| Jin, Y | 1 |
| Cao, Q | 1 |
| Choi, SJ | 1 |
| Oh, JM | 1 |
| Choy, JH | 1 |
| Mao, FJ | 1 |
| Sidorova, JM | 1 |
| Lauper, JM | 1 |
| Emond, MJ | 1 |
| Monnat, RJ | 1 |
| Shatz, M | 1 |
| Menendez, D | 1 |
| Resnick, MA | 1 |
| Dogan, M | 1 |
| Karabulut, HG | 1 |
| Tukun, A | 1 |
| Demirkazik, A | 1 |
| Utkan, G | 1 |
| Yalcin, B | 1 |
| Dincol, D | 1 |
| Akbulut, H | 1 |
| Icli, F | 1 |
| KNOCK, FE | 1 |
| MCBRIDE, TJ | 1 |
| NOBLE, LC | 1 |
| CARR, MA | 1 |
| HULL, K | 1 |
| OLESON, JJ | 1 |
| Ramnaraine, M | 1 |
| Pan, W | 1 |
| Goblirsch, M | 1 |
| Lynch, C | 1 |
| Lewis, V | 1 |
| Orchard, P | 1 |
| Mantyh, P | 1 |
| Clohisy, DR | 1 |
| Wei, J | 1 |
| Blum, S | 1 |
| Unger, M | 1 |
| Jarmy, G | 1 |
| Lamparter, M | 1 |
| Geishauser, A | 1 |
| Vlastos, GA | 1 |
| Chan, G | 1 |
| Fischer, KD | 1 |
| Rattat, D | 1 |
| Debatin, KM | 1 |
| Hatzopoulos, AK | 1 |
| Beltinger, C | 1 |
| Zhao, J | 1 |
| Jin, J | 1 |
| Zhang, X | 1 |
| Shi, M | 1 |
| Dai, J | 1 |
| Wu, M | 1 |
| Wang, R | 1 |
| Takeuchi, S | 3 |
| Akahoshi, Y | 2 |
| Kasai, C | 1 |
| Nishimoto, Y | 1 |
| Markman, M | 1 |
| Armstrong, RD | 1 |
| Cadman, E | 1 |
| Mulder, JH | 3 |
| Smink, T | 3 |
| Ossewaarde, T | 1 |
| van Putten, LM | 4 |
| Land, VJ | 1 |
| Dyment, PG | 1 |
| Starling, K | 1 |
| Strandjord, SE | 1 |
| Chan, R | 1 |
| Schabel, FM | 1 |
| Skipper, HE | 1 |
| Trader, MW | 1 |
| Laster, WR | 1 |
| Corbett, TH | 1 |
| Griswold, DP | 1 |
| DeVita, VT | 2 |
| Henney, JE | 1 |
| Weiss, RB | 2 |
| Pratt, CB | 1 |
| Meyer, WH | 1 |
| Howlett, N | 1 |
| Douglass, EC | 1 |
| Bowman, LC | 1 |
| Poe, D | 1 |
| Mounce, K | 1 |
| Kun, LE | 1 |
| Houghton, JA | 1 |
| Levine, RA | 1 |
| Fleischli, MA | 1 |
| Zeng, J | 1 |
| Hu, Y | 1 |
| Pei, F | 1 |
| Lei, S | 1 |
| Mao, Y | 1 |
| Wei, Y | 1 |
| Lelieveld, P | 1 |
| Pantarotto, C | 1 |
| Salmona, M | 1 |
| Spreafico, F | 1 |
| Livingston, RB | 1 |
| Rozencweig, M | 1 |
| von Hoff, DD | 1 |
| Louie, AC | 1 |
| Muggia, FM | 1 |
| Hill, GJ | 1 |
| Johnson, RO | 1 |
| Metter, G | 1 |
| Wilson, WL | 1 |
| Davis, HL | 1 |
| Grage, T | 1 |
| Fletcher, WS | 1 |
| Golomb, FM | 1 |
| Cruz, AB | 1 |
| Chen, SH | 1 |
| Nishimoto, T | 1 |
| Kikuike, A | 1 |
| Yonezawa, H | 1 |
| Yamamuro, T | 1 |
| Cohen, P | 1 |
| Costanzi, JJ | 1 |
| Coltman, CA | 1 |
| Takagi, M | 1 |
| Ishikawa, G | 1 |
| Akarhoshi, Y | 1 |
| Nishimgto, T | 1 |
| Freckman, HA | 1 |
| Banzet, P | 1 |
| De la Caffinière, JY | 1 |
| Dufourmentel, C | 1 |
| Ohno, T | 1 |
3 reviews available for fluorouracil and Osteogenic Sarcoma
| Article | Year |
|---|---|
Advances in the multimodal primary management of cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphami | 1980 |
Chemotherapy of solid tumors. Recent advances.
Topics: Adult; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Bronchogenic; Carcinom | 1976 |
Multimodal primary cancer treatment (adjuvant chemotherapy): current results and future prospects.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Colonic Neoplasms; Evaluation Stud | 1979 |
3 trials available for fluorouracil and Osteogenic Sarcoma
| Article | Year |
|---|---|
Newer techniques in cancer chemotherapy.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bleomycin; Bone Marrow Transplantation; Carcinoma; Ce | 1984 |
Advances in the multimodal primary management of cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphami | 1980 |
Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors.
Topics: Adolescent; Carcinoma; Child; Child, Preschool; Colorectal Neoplasms; Drug Administration Schedule; | 1994 |
40 other studies available for fluorouracil and Osteogenic Sarcoma
| Article | Year |
|---|---|
From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Carbazoles; Cell Line, Tumor; Cell Proliferation; | 2022 |
HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Fem | 2021 |
Targeting the 'garbage-bin' to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU.
Topics: Fluorouracil; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; H | 2021 |
Post-Transcriptional Control of Angiotensin II Type 1 Receptor Regulates Osteosarcoma Cell Death.
Topics: Aged; Animals; Apoptosis; Base Sequence; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Disease Pr | 2018 |
Synergistic cytotoxic effects of inorganic phosphate and chemotherapeutic drugs on human osteosarcoma cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Ce | 2013 |
Osteopontin upregulates the expression of glucose transporters in osteosarcoma cells.
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Daunorubicin; Etoposide; Fluorouracil; Gluc | 2014 |
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Binding Sites; Cell Line, Tumor; Colonic Neoplasms; Fluo | 2016 |
Anticancer drugs with chemotherapeutic interactions with thymoquinone in osteosarcoma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Bone Neoplasms; Cell Proliferation; Cell Survival; | 2016 |
Influence of spray-dried hydroxyapatite-5-fluorouracil granules on cell lines derived from tissues of mesenchymal origin.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Line, Tumor; Cell Lineage; Cell Proliferat | 2008 |
Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line; Cell Line, Tumor; Cell Survival; Dos | 2009 |
Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Cycle; Cell Proliferation; Colonic Neoplasms; | 2009 |
The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells.
Topics: Autophagy; Carboplatin; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Drug Therapy, Combinat | 2010 |
Biocompatible nanoparticles intercalated with anticancer drug for target delivery: pharmacokinetic and biodistribution study.
Topics: Animals; Antineoplastic Agents; Crystallization; Drug Carriers; Drug Compounding; Female; Fluorourac | 2010 |
The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage.
Topics: Antineoplastic Agents; Bone Neoplasms; Bromodeoxyuridine; Camptothecin; Cell Growth Processes; Cell | 2010 |
The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells.
Topics: Adenocarcinoma; Bone Neoplasms; Breast Neoplasms; Cell Line; Cytokines; DNA Damage; DNA, Neoplasm; D | 2012 |
Relationship between antimetabolite toxicity and pharmacogenetics in Turkish cancer patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alleles; Antimetabolites, Antineop | 2012 |
COORDINATED SURGICAL-CHEMICAL THERAPY OF CANCER.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cyclophosphamide; DNA; DNA, Neoplasm; Fluorouracil; | 1963 |
CHEMOTHERAPEUTIC STUDIES WITH OSTEOGENIC SARCOMA HE10734.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Fl | 1964 |
Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Fluorouracil; Genetic Th | 2003 |
Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.
Topics: Animals; Bone Neoplasms; Bystander Effect; Carcinoma, Lewis Lung; Cell Hypoxia; Cytosine Deaminase; | 2004 |
Transfection of Smac sensitizes tumor cells to etoposide-induced apoptosis and eradicates established human hepatoma in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Re | 2006 |
[Clinical evaluation on the sensitivity test for anti-cancer agents in malignant bone and soft-tissue tumors].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; | 1984 |
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine; | 1983 |
Schedule-dependent cytotoxicity of 5-fluorouracil and cyclophosphamide in experimental cancer chemotherapy.
Topics: Animals; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Leukemia L1210; Lung Neoplasm | 1980 |
5-fluorouracil and cis-platinum in the treatment of refractory solid tumors: a pediatric oncology group phase I-II study.
Topics: Adolescent; Adult; Child; Cisplatin; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Co | 1981 |
Concepts for controlling drug-resistant tumor cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Burden; Cisplatin; Cyclophosphamide; Dactinomyc | 1980 |
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemi | 1981 |
Inactivation of p53 and retinoblastoma family pathways in canine osteosarcoma cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Blotting, Northern; Blotting, Western; Bone Neoplasms; DNA | 2000 |
[Flow cytometry for testing chemosensitivity of malignant bone tumors].
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neop | 1999 |
Ftorafur: a self-limiting source of 5-fluorouracil?
Topics: Animals; Biotransformation; Fluorouracil; Hematopoietic Stem Cells; Lethal Dose 50; Leukemia L1210; | 1979 |
Schedule dependent effectiveness of CCNU and 5-fluorouracil in experimental chemotherapy.
Topics: Animals; Cell Survival; Drug Therapy, Combination; Fluorouracil; Hematopoietic Stem Cells; Lomustine | 1977 |
Current trends and prospects in surgical adjuvant trials.
Topics: Antineoplastic Agents; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Dianhydroga | 1978 |
Multimodal surgical adjuvant therapy for a broad spectrum of tumors in humans.?
Topics: Adult; Altretamine; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Carmustine; Colonic Neo | 1976 |
The results of surgical treatment combined with intra-arterial infusion of anti-cancer agents in osteosarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Child; Extremities; Fem | 1976 |
[Treatment of osteosarcoma: an end to the present impasse?].
Topics: Cyclophosphamide; Doxorubicin; Fluorouracil; Humans; International Cooperation; Lung Neoplasms; Mito | 1976 |
Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumors.
Topics: Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fibrosarcoma; Fluorouraci | 1969 |
[Pathologic study of the therapeutic effects in the osteosarcoma treated with continuous intra-arterial infusion (author's transl)].
Topics: Adolescent; Bone and Bones; Bone Neoplasms; Child; Female; Fluorouracil; Humans; Injections, Intra-A | 1974 |
Results in 169 patients with cancer of the head and neck treated by intra-arterial infusion therapy.
Topics: Antineoplastic Agents; Brachial Artery; Brachiocephalic Trunk; Carcinoma, Squamous Cell; Carotid Art | 1972 |
[Apropos of 40 cases of malignant tumors treated by local-regional and general chemotherapy in a surgical department].
Topics: Adolescent; Adult; Aminopterin; Back; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemotherapy, | 1969 |
Bronchial artery infusion with anticancer agents in the treatment of osteosarcoma. Prevention of pulmonary metastasis and improvement of prognosis.
Topics: Adolescent; Adult; Angiography; Aortic Coarctation; Blood Cell Count; Bronchial Arteries; Catheteriz | 1971 |