fluorouracil has been researched along with Orphan Diseases in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Orphan Diseases: Rare diseases that have not been well studied.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A colorectal cancer patient receiving chemotherapy (5-fluorouracil and oxaliplatin) plus bevacizumab developed acute, severe thrombocytopenia." | 3.78 | A rare hematological adverse event induced by bevacizumab: severe thrombocytopenia. ( Brezault, C; Chaussade, S; Coriat, R; Dhooge, M; Dior, M; Goldwasser, F; Mir, O; Perkins, G, 2012) |
| "Basaloid squamous cell carcinoma (BSCC) is a high-grade variant of squamous cell carcinoma usually localized in the aerodigestive tract, with a poor prognosis." | 1.40 | Basaloid squamous cell carcinoma: a rare tumor at the esophagogastric junction and an unexpected durable complete response to FOLFOX-4. ( Attademo, L; Camera, L; Carlomagno, C; Cella, CA; D'Armiento, M; De Stefano, A; Feliciano, S; Guadagno, E; Lordick, F; Matano, E; Moretto, R; Raimondo, L, 2014) |
| "Synchronous gastric and pancreatic cancers represent a very rare association." | 1.39 | Double pancreatic and gastric adenocarcinomas: a rare association. ( Cuenod, CA; Dubreuil, O; Fabre, M; Kourie, HR; Landi, B; Markoutsaki, N; Palazzo, L; Rahmi, G; Rougier, P; Roussel, H; Taieb, J; Van der Stiegel, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cella, CA | 1 |
| Carlomagno, C | 1 |
| Lordick, F | 1 |
| Moretto, R | 1 |
| De Stefano, A | 1 |
| Raimondo, L | 1 |
| D'Armiento, M | 1 |
| Camera, L | 1 |
| Guadagno, E | 1 |
| Attademo, L | 1 |
| Feliciano, S | 1 |
| Matano, E | 1 |
| Gaduputi, V | 1 |
| Tariq, H | 1 |
| Ihimoyan, A | 1 |
| Piotrowski, MJ | 1 |
| Gunn, H | 1 |
| Kirby, J | 1 |
| Ali, L | 1 |
| Helm, K | 1 |
| Kruger, S | 1 |
| Haas, M | 1 |
| Burger, PJ | 1 |
| Ormanns, S | 1 |
| Modest, DP | 1 |
| Westphalen, CB | 1 |
| Kleespies, A | 1 |
| Angele, MK | 1 |
| Hartwig, W | 1 |
| Bruns, CJ | 1 |
| Kirchner, T | 1 |
| Werner, J | 1 |
| Heinemann, V | 1 |
| Boeck, S | 1 |
| Kalpande, S | 1 |
| Pandya, J | 1 |
| Sharma, T | 1 |
| Dior, M | 1 |
| Coriat, R | 1 |
| Mir, O | 1 |
| Brezault, C | 1 |
| Perkins, G | 1 |
| Dhooge, M | 1 |
| Goldwasser, F | 1 |
| Chaussade, S | 1 |
| Kourie, HR | 1 |
| Markoutsaki, N | 1 |
| Roussel, H | 1 |
| Rahmi, G | 1 |
| Van der Stiegel, M | 1 |
| Palazzo, L | 1 |
| Fabre, M | 1 |
| Cuenod, CA | 1 |
| Dubreuil, O | 1 |
| Landi, B | 1 |
| Rougier, P | 1 |
| Taieb, J | 1 |
| Zawar, V | 1 |
| Kirloskar, M | 1 |
| Chuh, A | 1 |
| Lazar, A | 1 |
| Mau-Holzmann, UA | 1 |
| Kolb, H | 1 |
| Reichenmiller, HE | 1 |
| Riess, O | 1 |
| Schömig, E | 1 |
1 review available for fluorouracil and Orphan Diseases
| Article | Year |
|---|---|
JAAD Grand Rounds quiz: Red-brown hyperkeratotic papules in a 69-year-old man.
Topics: Aged; Biopsy, Needle; Disease Progression; Exanthema; Fluorouracil; Follow-Up Studies; Humans; Immun | 2015 |
8 other studies available for fluorouracil and Orphan Diseases
| Article | Year |
|---|---|
Basaloid squamous cell carcinoma: a rare tumor at the esophagogastric junction and an unexpected durable complete response to FOLFOX-4.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Esophagogastric Junc | 2014 |
A rare cause of esophagitis with crystal deposition.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Crystallization; Esoph | 2015 |
Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Acinar Cell; Carcinoma, Pan | 2016 |
Adenocarcinoma mimicking appendicular lump: a diagnostic dilemma-a case report.
Topics: Abdominal Abscess; Adenocarcinoma; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Appe | 2016 |
A rare hematological adverse event induced by bevacizumab: severe thrombocytopenia.
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera | 2012 |
Double pancreatic and gastric adenocarcinomas: a rare association.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Fluorouracil; Humans; | 2013 |
'Watering-can penis' in pseudoepitheliomatous, keratotic and micaceous balanitis.
Topics: Administration, Topical; Balanitis; Biopsy, Needle; Carcinoma, Verrucous; Diagnosis, Differential; F | 2004 |
Multiple organ failure due to 5-fluorouracil chemotherapy in a patient with a rare dihydropyrimidine dehydrogenase gene variant.
Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Cecal Neoplasms; Dihydropyrimidine Dehydrogenase Defic | 2004 |