Page last updated: 2024-10-27

fluorouracil and Orbital Neoplasms

fluorouracil has been researched along with Orbital Neoplasms in 17 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Orbital Neoplasms: Neoplasms of the bony orbit and contents except the eyeball.

Research Excerpts

ExcerptRelevanceReference
"We report a durable (12-month) response to capecitabine monotherapy, shown clinically, by MRI, and by cerebrospinal fluid analysis, in a patient with leptomeningeal metastasis from breast cancer."7.72Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy. ( Remer, SE; Rogers, LR; Tejwani, S, 2004)
"A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower eyelid with orbital extension and regional lymph node metastasis was treated with neoadjuvant chemotherapy, using a combination of carboplatin and 5-fluorouracil."3.73Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis. ( Burman, S; Honavar, SG; Murthy, R; Naik, MN; Reddy, VA; Vemuganti, GK, 2005)
"We report a durable (12-month) response to capecitabine monotherapy, shown clinically, by MRI, and by cerebrospinal fluid analysis, in a patient with leptomeningeal metastasis from breast cancer."3.72Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy. ( Remer, SE; Rogers, LR; Tejwani, S, 2004)
"A patient with recurrent breast cancer, who was diagnosed with eyelid metastasis as a part of systemic metastases and in whom systemic chemotherapy was markedly effective, is reported."2.39Eyelid metastasis from breast cancer showing marked response to chemotherapy. ( Abe, K; Adachi, I; Kaneko, A; Narabayashi, M; Tokue, Y; Tsuda, H; Watanabe, T; Yin, DF; Zhang, GJ, 1995)
"Many cases with metastatic hepatic cancer have a poor prognosis because of the appearance of extrahepatic lesions in spite of the fact that a partial response can be obtained by hepatic arterial infusion chemotherapy."1.30[Appearance of extrahepatic lesions in the superior lip and orbit of a patient with liver metastases of gastric cancer following partial response by hepatic arterial infusion chemotherapy]. ( Hasegawa, K; Ichikawa, T; Kawai, S; Kirihara, M; Kume, S; Maruo, H; Tominaga, S, 1998)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.76)18.7374
1990's4 (23.53)18.2507
2000's5 (29.41)29.6817
2010's5 (29.41)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Li, R1
Tian, S1
Zhu, Y1
Zhu, W1
Wang, S1
Gogia, A1
Pushker, N1
Sen, S1
Bakhshi, S1
De Stefani, A1
Boffano, P1
Bongioannini, G1
Nair, AG1
Kaliki, S1
Mishra, DK1
Reddy, VA2
Naik, MN2
Fukui, T1
Yoshioka, T1
Takano, J1
Fujishima, S1
Otake, S1
Orii, T1
Sato, T1
Sasaki, Y1
Nishise, S1
Takeda, H1
Kawata, S1
Takamura, H1
Mutyala, V1
Bains, S1
Patil, C1
Madhavarao, B1
Sullivan, TJ1
Rogers, LR1
Remer, SE1
Tejwani, S1
Murthy, R1
Honavar, SG1
Burman, S1
Vemuganti, GK1
Copcu, E1
Sivrioglu, N1
Baytekin, C1
Er, S1
Koc, B1
Char, DH1
Crawford, JB1
Bellman, B1
Gregory, NA1
Silvers, D1
Fountain, KS1
Zhang, GJ1
Adachi, I1
Yin, DF1
Narabayashi, M1
Tokue, Y1
Watanabe, T1
Kaneko, A1
Tsuda, H1
Abe, K1
Maruo, H1
Kirihara, M1
Hasegawa, K1
Kawai, S1
Tominaga, S1
Ichikawa, T1
Kume, S1
Lubec, G1
Szalay, S1
Bergman, RB1
Pfeiffer, P1
Madsen, EL1
Hansen, O1
May, O1

Reviews

2 reviews available for fluorouracil and Orbital Neoplasms

ArticleYear
Topical therapies for periorbital cutaneous malignancies: indications and treatment regimens.
    Current opinion in ophthalmology, 2012, Volume: 23, Issue:5

    Topics: Administration, Topical; Aminoquinolines; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, S

2012
Eyelid metastasis from breast cancer showing marked response to chemotherapy.
    Japanese journal of clinical oncology, 1995, Volume: 25, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Lobular

1995

Trials

1 trial available for fluorouracil and Orbital Neoplasms

ArticleYear
Effect of prophylactic sucralfate suspension on stomatitis induced by cancer chemotherapy. A randomized, double-blind cross-over study.
    Acta oncologica (Stockholm, Sweden), 1990, Volume: 29, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Double-Blind Meth

1990

Other Studies

14 other studies available for fluorouracil and Orbital Neoplasms

ArticleYear
Management of orbital invasion in sinonasal squamous cell carcinoma: 15 years' experience.
    International forum of allergy & rhinology, 2020, Volume: 10, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol

2020
Avoidance of exenteration in orbital sebaceous gland carcinoma with neoadjuvant chemotherapy.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2013, Volume: 251, Issue:10

    Topics: Adenocarcinoma, Sebaceous; Cisplatin; Eye Evisceration; Eyelid Neoplasms; Fluorouracil; Humans; Male

2013
The management of an orbital diffuse large B-cell lymphoma.
    The Journal of craniofacial surgery, 2014, Volume: 25, Issue:4

    Topics: Aged; Antibiotics, Antineoplastic; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined C

2014
Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report.
    Indian journal of ophthalmology, 2015, Volume: 63, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Conjunct

2015
[A case of primary orbital adenocarcinoma responding to chemoradiation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cisplatin; Combined Modality

2009
Bilateral acute ptosis leading to the diagnosis of a presumed metastatic gastric adenocarcinoma.
    Orbit (Amsterdam, Netherlands), 2012, Volume: 31, Issue:2

    Topics: Acute Disease; Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Blepharoptosis; Capec

2012
Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy.
    Neuro-oncology, 2004, Volume: 6, Issue:1

    Topics: Adult; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidi

2004
Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis.
    Ophthalmic plastic and reconstructive surgery, 2005, Volume: 21, Issue:4

    Topics: Adenocarcinoma, Sebaceous; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Eyelid Neopl

2005
How can we decide on orbital exenteration for second eye in a patient with basal cell carcinoma?
    Plastic and reconstructive surgery, 2006, Volume: 117, Issue:7

    Topics: Aged; Antineoplastic Agents; Carcinoma, Basal Cell; Cheek; Dose Fractionation, Radiation; Fluorourac

2006
Orbital invasion despite topical anti-metabolite therapy for conjunctival carcinoma.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2008, Volume: 246, Issue:3

    Topics: Administration, Topical; Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Con

2008
Sweat gland carcinoma with metastases to the skin: response to 5-fluorouracil chemotherapy.
    Cutis, 1995, Volume: 55, Issue:4

    Topics: Aged; Bone Marrow Diseases; Bone Neoplasms; Carcinoma, Signet Ring Cell; Facial Neoplasms; Fluoroura

1995
[Appearance of extrahepatic lesions in the superior lip and orbit of a patient with liver metastases of gastric cancer following partial response by hepatic arterial infusion chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Epirubicin; Fluo

1998
[5-fluorouracil inhibits bacterial collagenase and the collagenolytic system of a human rhabdomyosarcoma].
    Onkologie, 1979, Volume: 2, Issue:1

    Topics: Cells, Cultured; Clostridium; Collagen; Drug Evaluation, Preclinical; Enzyme Activation; Fluorouraci

1979
[Experiences in the treatment of 2 patients with xeroderma pigmentosum].
    Nederlands tijdschrift voor geneeskunde, 1976, Aug-21, Volume: 120, Issue:34

    Topics: Adolescent; Adult; Brain Neoplasms; Female; Fluorouracil; Humans; Leiomyosarcoma; Male; Melanoma; Ne

1976