fluorouracil has been researched along with Oral Ulcer in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Oral Ulcer: A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the side-effects experienced by patients with colorectal cancer receiving 5-fluorouracil + folinic acid chemotherapy." | 7.70 | Patients' experiences of chemotherapy: side-effects associated with 5-fluorouracil + folinic acid in the treatment of colorectal cancer. ( Dikken, C; Sitzia, J, 1998) |
| "The purpose of this study was to investigate the side-effects experienced by patients with colorectal cancer receiving 5-fluorouracil + folinic acid chemotherapy." | 3.70 | Patients' experiences of chemotherapy: side-effects associated with 5-fluorouracil + folinic acid in the treatment of colorectal cancer. ( Dikken, C; Sitzia, J, 1998) |
| "Oral mucositis was induced in hamsters by administration of 5-fluorouracil (day 0, 2, 4) followed by mechanical trauma (day 1, 2, 4)." | 1.56 | Wound Healing Promoting Activity of Tonsil-Derived Stem Cells on 5-Fluorouracil-Induced Oral Mucositis Model. ( Jung, H; Kim, HS; Lee, JH; Lee, JJ; Park, HS, 2020) |
| " It is suggested that the ethanol extracts were beneficial to the absorption and bioavailability of TG which was one of the most important bioactive compounds of Belamcandae Rhizoma in pharmacokinetic study in rats." | 1.48 | A novel strategy to evaluate the quality of herbal products based on the chemical profiling, efficacy evaluation and pharmacokinetics. ( He, L; Li, X; Lin, Y; Peng, R; Wen, Y; Yang, J; Ye, L; Zhao, L, 2018) |
| "Weight gain was noted in the treatment groups compared with the gel base and control groups (P < ." | 1.39 | Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis. ( Amanat, D; Garcia-Godoy, F; Saghiri, MA; Samani, SM; Tadbir, AA; Tamadon, A; Tanideh, N; Tavakoli, P, 2013) |
| "Oral mucositis is a frequent side-effect of cancer therapy." | 1.33 | Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters. ( Augusto, RF; Brito, GA; Cunha, FQ; Falcão, BA; Leitão, BT; Lima, V; Rebouças, CG; Ribeiro, RA; Souza, ML, 2005) |
| "Oral mucositis was induced in hamsters through a combination treatment of 5-fluorouracil and mild abrasion of the cheek pouch." | 1.33 | Evaluation of topical external medicine for 5-fluorouracil-induced oral mucositis in hamsters. ( Araki, H; Cui, R; Li, B; Mitsuhashi, H; Suemaru, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, H | 1 |
| Kim, HS | 1 |
| Lee, JH | 1 |
| Lee, JJ | 1 |
| Park, HS | 1 |
| Wen, Y | 1 |
| He, L | 1 |
| Peng, R | 1 |
| Lin, Y | 1 |
| Zhao, L | 1 |
| Li, X | 1 |
| Ye, L | 1 |
| Yang, J | 1 |
| Tanideh, N | 1 |
| Tavakoli, P | 1 |
| Saghiri, MA | 1 |
| Garcia-Godoy, F | 1 |
| Amanat, D | 1 |
| Tadbir, AA | 1 |
| Samani, SM | 1 |
| Tamadon, A | 1 |
| Dörr, W | 1 |
| Bässler, S | 1 |
| Reichel, S | 1 |
| Spekl, K | 1 |
| Lima, V | 1 |
| Brito, GA | 1 |
| Cunha, FQ | 1 |
| Rebouças, CG | 1 |
| Falcão, BA | 1 |
| Augusto, RF | 1 |
| Souza, ML | 1 |
| Leitão, BT | 1 |
| Ribeiro, RA | 1 |
| Cho, SA | 1 |
| Park, JH | 2 |
| Seok, SH | 1 |
| Juhn, JH | 1 |
| Kim, SJ | 1 |
| Ji, HJ | 1 |
| Choo, YS | 1 |
| Mitsuhashi, H | 1 |
| Suemaru, K | 1 |
| Li, B | 1 |
| Cui, R | 1 |
| Araki, H | 1 |
| Lara, RN | 1 |
| da Guerra, EN | 1 |
| de Melo, NS | 1 |
| Sonis, ST | 1 |
| Van Vugt, AG | 1 |
| McDonald, J | 1 |
| Dotoli, E | 1 |
| Schwertschlag, U | 1 |
| Szklut, P | 1 |
| Keith, J | 1 |
| Dikken, C | 1 |
| Sitzia, J | 1 |
10 other studies available for fluorouracil and Oral Ulcer
| Article | Year |
|---|---|
Wound Healing Promoting Activity of Tonsil-Derived Stem Cells on 5-Fluorouracil-Induced Oral Mucositis Model.
Topics: Animals; Child; Cricetinae; Culture Media, Conditioned; Disease Models, Animal; Female; Fluorouracil | 2020 |
A novel strategy to evaluate the quality of herbal products based on the chemical profiling, efficacy evaluation and pharmacokinetics.
Topics: Analytic Sample Preparation Methods; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese H | 2018 |
Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis.
Topics: Abscess; Animals; Antimetabolites, Antineoplastic; Calendula; Carboxymethylcellulose Sodium; Criceti | 2013 |
Reduction of radiochemotherapy-induced early oral mucositis by recombinant human keratinocyte growth factor (palifermin): experimental studies in mice.
Topics: Animals; Cisplatin; Dose Fractionation, Radiation; Drug Evaluation, Preclinical; Fibroblast Growth F | 2005 |
Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters.
Topics: Abscess; Animals; Antimetabolites, Antineoplastic; Cricetinae; Disease Models, Animal; Edema; Erythe | 2005 |
Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches.
Topics: Administration, Topical; Animals; Anti-Ulcer Agents; Biomarkers; Cricetinae; Disease Models, Animal; | 2006 |
Evaluation of topical external medicine for 5-fluorouracil-induced oral mucositis in hamsters.
Topics: Administration, Topical; Alginates; Analysis of Variance; Animals; Anti-Inflammatory Agents; Anti-Ul | 2006 |
Macroscopic and microscopic effects of GaAIAs diode laser and dexamethasone therapies on oral mucositis induced by fluorouracil in rats.
Topics: Aluminum; Animals; Anti-Inflammatory Agents; Antimetabolites; Arsenicals; Biofilms; Dexamethasone; D | 2007 |
Mitigating effects of interleukin 11 on consecutive courses of 5-fluorouracil-induced ulcerative mucositis in hamsters.
Topics: Animals; Blood Cell Count; Bone Marrow Cells; Cricetinae; Fluorouracil; Interleukin-11; Male; Mesocr | 1997 |
Patients' experiences of chemotherapy: side-effects associated with 5-fluorouracil + folinic acid in the treatment of colorectal cancer.
Topics: Adenocarcinoma; Aged; Alopecia; Antidotes; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Di | 1998 |