fluorouracil has been researched along with Optic Neuritis in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Optic Neuritis: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
| Excerpt | Relevance | Reference |
|---|---|---|
| "For over 50 years, 5-Fluorouracil has played a critical role in the treatment of numerous malignancies, including colorectal cancer." | 7.96 | Optic neuritis induced by 5-fluorouracil chemotherapy: Case report and review of the literature. ( Gilbar, PJ; Grewal, GD; Holcombe, DJ; Raina, AJ, 2020) |
| "For over 50 years, 5-Fluorouracil has played a critical role in the treatment of numerous malignancies, including colorectal cancer." | 3.96 | Optic neuritis induced by 5-fluorouracil chemotherapy: Case report and review of the literature. ( Gilbar, PJ; Grewal, GD; Holcombe, DJ; Raina, AJ, 2020) |
| "A case of retrobulbar neuritis which developed in association with intraarterial continuous infusion cisplatin is presented." | 1.27 | Retrobulbar neuritis in a patient treated with intraarterial cisplatin for head and neck cancer. ( Forastiere, AA; Urba, S, 1988) |
| "A case of primary hemangioendothelioma is presented." | 1.26 | Primary malignant hemangioendothelioma of the liver: survival following nonoperative treatment. ( El-Mahdi, A; Langley, JR; Rosato, FE, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raina, AJ | 1 |
| Gilbar, PJ | 1 |
| Grewal, GD | 1 |
| Holcombe, DJ | 1 |
| Elnahry, AG | 1 |
| Elnahry, GA | 1 |
| Langley, JR | 1 |
| Rosato, FE | 1 |
| El-Mahdi, A | 1 |
| Urba, S | 1 |
| Forastiere, AA | 1 |
1 review available for fluorouracil and Optic Neuritis
| Article | Year |
|---|---|
Response to: Optic neuritis induced by 5-fluorouracil chemotherapy: case report and review of the literature.
Topics: Colorectal Neoplasms; Fluorouracil; Humans; Magnetic Resonance Imaging; Optic Neuritis | 2020 |
3 other studies available for fluorouracil and Optic Neuritis
| Article | Year |
|---|---|
Optic neuritis induced by 5-fluorouracil chemotherapy: Case report and review of the literature.
Topics: Administration, Intravenous; Antineoplastic Agents; Colorectal Neoplasms; Fluorouracil; Glucocortico | 2020 |
Primary malignant hemangioendothelioma of the liver: survival following nonoperative treatment.
Topics: Fluorouracil; Hemangioendothelioma; Humans; Liver Neoplasms; Male; Middle Aged; Optic Neuritis | 1978 |
Retrobulbar neuritis in a patient treated with intraarterial cisplatin for head and neck cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Fluorouracil; Head and Neck Neoplas | 1988 |