fluorouracil has been researched along with Optic Nerve Diseases in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Optic Nerve Diseases: Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a 72-year-old woman suffering from bone metastatic breast cancer and treated with continuous intravenous 5 fluorouracil (5FU) chemotherapy, who presented with a bilateral asymmetric anterior optic neuropathy (ON)." | 4.81 | Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature. ( Delval, L; Klastersky, J, 2002) |
| "Juvenile-onset Open Angle Glaucoma (JOAG) has been proposed to be a small subset of Primary Open Angle Glaucoma (POAG) and on a continual spectrum of Primary Open Angle Glaucoma." | 1.35 | Bilateral ocular hypertension with rapidly progressive optic neuropathy in a teen. ( Byrne, E; Hua, LV; Yudcovitch, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Turner, LD | 1 |
| Harrison, JD | 1 |
| Chao, D | 1 |
| Chen, WC | 1 |
| Thirkill, CE | 1 |
| Lee, AG | 1 |
| Kotecha, A | 1 |
| Spratt, A | 1 |
| Bunce, C | 1 |
| Garway-Heath, DF | 1 |
| Khaw, PT | 1 |
| Viswanathan, A | 1 |
| Hua, LV | 1 |
| Byrne, E | 1 |
| Yudcovitch, L | 1 |
| Delval, L | 1 |
| Klastersky, J | 1 |
| Mehta, JS | 1 |
| Maurino, V | 1 |
| Patel, H | 1 |
| Kirwin, J | 1 |
| Murdoch, IE | 1 |
| Slezak, H | 1 |
| Adams, JW | 1 |
| Bofenkamp, TM | 1 |
| Kobrin, J | 1 |
| Wirtschafter, JD | 1 |
| Zeese, JA | 1 |
1 review available for fluorouracil and Optic Nerve Diseases
| Article | Year |
|---|---|
Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature.
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Fluorouracil; Humans; Optic Nerve D | 2002 |
1 trial available for fluorouracil and Optic Nerve Diseases
| Article | Year |
|---|---|
Optic disc and visual field changes after trabeculectomy.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Disease Progression; Dou | 2009 |
6 other studies available for fluorouracil and Optic Nerve Diseases
| Article | Year |
|---|---|
Bilateral optic disc oedema and associated optic neuropathy in the setting of FOLFOX chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Leucovor | 2013 |
Paraneoplastic optic neuropathy and retinopathy associated with colon adenocarcinoma.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colonoscopy; Comb | 2013 |
Bilateral ocular hypertension with rapidly progressive optic neuropathy in a teen.
Topics: Adolescent; Antimetabolites; Disease Progression; Female; Fluorouracil; Fundus Oculi; Glaucoma, Open | 2009 |
Immediate postoperative intraocular pressure measurements after trabeculectomy with releasable sutures.
Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; False Negative Reactions; Female; Fluorou | 2006 |
[Drug-induced eye lesions in the aged].
Topics: Aged; Antipsychotic Agents; Aspirin; Cataract; Conjunctival Diseases; Corneal Diseases; Eye Diseases | 1983 |
Recurrent acute toxic optic neuropathy secondary to 5-FU.
Topics: Female; Fluorouracil; Humans; Middle Aged; Optic Nerve Diseases; Recurrence | 1984 |