fluorouracil has been researched along with Opportunistic Infections in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azotemia, body fluid insufficiency and bacterial infections were frequently found in these patients." | 5.30 | Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection. ( Chang, HK; Chen, JS; Liaw, CC; Liaw, SJ; Lin, YC; Wang, CH; Wang, HM; Yang, TS; Yeh, CT, 1999) |
| "This randomized phase 2 study explored the feasibility of delivering four to six cycles of the dose-intensified regimen FEC-100 (5-fluorouracil, epirubicin, and cyclophosphamide) to elderly patients with stage II-III breast cancer, using pegfilgrastim for neutrophil support." | 5.12 | Pegfilgrastim supports delivery of FEC-100 chemotherapy in elderly patients with high risk breast cancer: a randomized phase 2 trial. ( Bacon, P; Brugger, W; Clemens, M; Constenla, M; Easton, V; Fargeot, P; Mahlberg, R; Romieu, G; Schütte, M; Skacel, T, 2007) |
| " Breast cancer patients were receiving a 5-fluorouracil/epirubicin/cyclophosphamide (FEC) regimen (6 chemotherapy cycles), and colorectal cancer patients were receiving either an oxaliplatin/5-fluorouracil/folinic acid (FOLFOX) regimen (12 cycles) or a 5-fluorouracil/folinic acid (Mayo) regimen (6 cycles)." | 3.78 | Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? ( Anita, ZB; Chandramathi, S; Kuppusamy, UR; Suresh, K, 2012) |
| "Azotemia, body fluid insufficiency and bacterial infections were frequently found in these patients." | 1.30 | Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection. ( Chang, HK; Chen, JS; Liaw, CC; Liaw, SJ; Lin, YC; Wang, CH; Wang, HM; Yang, TS; Yeh, CT, 1999) |
| "He experienced amoebic dysentery during World War II some 40 years ago, thus, this case report suggested that amoebiasis relapsed by depressed cellular immunity and was calculated as one of the opportunistic infections." | 1.28 | [Amoebic dysentery: a relapsing case by cancer chemotherapy]. ( Takenaka, A, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Santana, AB | 1 |
| Souto, BS | 1 |
| Santos, NCM | 1 |
| Pereira, JA | 1 |
| Tagliati, CA | 1 |
| Novaes, RD | 1 |
| Corsetti, PP | 1 |
| de Almeida, LA | 1 |
| Kovács, AF | 1 |
| Eberlein, K | 1 |
| Hülsmann, T | 1 |
| Chandramathi, S | 1 |
| Suresh, K | 1 |
| Anita, ZB | 1 |
| Kuppusamy, UR | 1 |
| Péron, J | 1 |
| Derbel, O | 1 |
| Penet, AS | 1 |
| Stella, M | 1 |
| Méeus, P | 1 |
| Orlandini, F | 1 |
| Pérol, M | 1 |
| de la Fouchardière, C | 1 |
| Yamaguchi, H | 2 |
| Ikeda, T | 1 |
| Ishibashi, H | 1 |
| Fujisaki, R | 1 |
| Yamazaki, M | 1 |
| Wakame, K | 1 |
| Kosuna, K | 1 |
| Ono, Y | 1 |
| Abe, S | 1 |
| Romieu, G | 1 |
| Clemens, M | 1 |
| Mahlberg, R | 1 |
| Fargeot, P | 1 |
| Constenla, M | 1 |
| Schütte, M | 1 |
| Easton, V | 1 |
| Skacel, T | 1 |
| Bacon, P | 1 |
| Brugger, W | 1 |
| Kish, JA | 1 |
| Wolf, MK | 1 |
| Schellhammer, PF | 1 |
| Hussain, MH | 1 |
| Einstein, AB | 1 |
| Crawford, ED | 1 |
| Liaw, CC | 1 |
| Wang, HM | 1 |
| Wang, CH | 1 |
| Yang, TS | 1 |
| Chen, JS | 1 |
| Chang, HK | 1 |
| Lin, YC | 1 |
| Liaw, SJ | 1 |
| Yeh, CT | 1 |
| Takenaka, A | 1 |
| Hardy, R | 1 |
| Cummings, C | 1 |
| Faulkner, M | 1 |
| Obianyo, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Label, Randomised, Multicentre Study of Pegfilgrastim in Primary Versus Secondary Prophylaxis of Neutropenia as an Adjunct to Chemotherapy in Elderly Subjects With High Risk Breast Cancer.[NCT00117910] | Phase 3 | 0 participants | Interventional | 2002-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Opportunistic Infections
| Article | Year |
|---|---|
[Antifungal drug].
Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Azoles; Caspofungin; Drug Design; Drug Res | 2003 |
3 trials available for fluorouracil and Opportunistic Infections
| Article | Year |
|---|---|
Organ preservation treatment using TPF-a pilot study in patients with advanced primary and recurrent cancer of the oral cavity and the maxillary sinus.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy P | 2009 |
Pegfilgrastim supports delivery of FEC-100 chemotherapy in elderly patients with high risk breast cancer: a randomized phase 2 trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin | 2007 |
Continuous-infusion 5-fluorouracil and cisplatin for advanced/recurrent transitional cell cancer of the bladder: a Southwest Oncology Group trial.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplast | 1997 |
7 other studies available for fluorouracil and Opportunistic Infections
| Article | Year |
|---|---|
Murine response to the opportunistic bacterium Pseudomonas aeruginosa infection in gut dysbiosis caused by 5-fluorouracil chemotherapy-induced mucositis.
Topics: Animals; Antineoplastic Agents; Bacteria; Dysbiosis; Fluorouracil; Intestinal Mucosa; Mice; Mice, In | 2022 |
Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blastocystis hominis; Breast Neoplasms; Col | 2012 |
Concomitant occurrence of pulmonary invasive aspergillosis and Pneumocystis pneumonia during FOLFIRINOX chemotherapy for pancreatic carcinoma.
Topics: Adenocarcinoma; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Proto | 2013 |
[Prophylactic efficacy of a basidiomycetes preparation AHCC against lethal Candida albicans infection in experimental granulocytopenic mice].
Topics: Adjuvants, Immunologic; Administration, Oral; Agranulocytosis; Animals; Basidiomycota; Candidiasis; | 2003 |
Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Bacterial Infections; Brain Diseases; Dehydration; Fem | 1999 |
[Amoebic dysentery: a relapsing case by cancer chemotherapy].
Topics: Aged; Carcinoma, Squamous Cell; Dysentery, Amebic; Fluorouracil; Humans; Immune Tolerance; Immunity, | 1989 |
Pneumocystis carinii pneumonia following 5-fluorouracil administration.
Topics: Fluorouracil; Humans; Male; Middle Aged; Opportunistic Infections; Pneumonia, Pneumocystis | 1987 |