fluorouracil has been researched along with Oligodendroglioma in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Oligodendroglioma: A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin." | 2.68 | Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor. ( Buckner, JC; Cascino, TL; Goldberg, RM; Kuross, SA; Levitt, R; Morton, RF; O'Fallon, JR; Scheithauer, BW; Veeder, MH; Wiesenfeld, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, K | 1 |
| Tabuchi, K | 1 |
| Furuta, T | 1 |
| Fujiwara, T | 1 |
| Nakasone, S | 1 |
| Ohnishi, R | 1 |
| Moriya, Y | 1 |
| Nishimoto, A | 1 |
| Doi, A | 1 |
| Asari, S | 1 |
| Bolla, M | 1 |
| Vincent, P | 1 |
| Benabid, A | 1 |
| Mousseau, M | 1 |
| de Rougemont, J | 1 |
| Vrousos, C | 1 |
| Kolodié, H | 1 |
| Vincent, F | 1 |
| Pasquier, B | 1 |
| Cascino, TL | 1 |
| Veeder, MH | 1 |
| Buckner, JC | 1 |
| O'Fallon, JR | 1 |
| Wiesenfeld, M | 1 |
| Levitt, R | 1 |
| Goldberg, RM | 1 |
| Kuross, SA | 1 |
| Morton, RF | 1 |
| Scheithauer, BW | 1 |
| Sano, K | 1 |
| Hoshino, T | 1 |
| Nagai, M | 1 |
| Ringkjob, R | 1 |
| Blokhina, NG | 1 |
| Vozny, EK | 1 |
| Garin, AM | 1 |
1 trial available for fluorouracil and Oligodendroglioma
| Article | Year |
|---|---|
Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor.
Topics: Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Astrocytoma; Brain Neoplasms; Female; Fluor | 1996 |
5 other studies available for fluorouracil and Oligodendroglioma
| Article | Year |
|---|---|
[Combination chemotherapy of brain tumors with ACNU and 5-FU].
Topics: Astrocytoma; Biological Products; Brain Neoplasms; Combined Modality Therapy; Drug Therapy, Combinat | 1983 |
[Association of 5-FU, CDDP and hypofractionated radiotherapy in recurrences of subtentorial astrocytomas and malignant gliomas in adults].
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; | 1990 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; | 1968 |
Treatment of intracranial gliomas and metastatic carcinomas by local application of cytostatic agents.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Female; Fluorouracil; Glioblastoma; | 1968 |
Results of treatment of malignant tumors with ftorafur.
Topics: Antimetabolites; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Colonic Neoplasms; Deoxyr | 1972 |