fluorouracil has been researched along with Ocular Hypertension in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Ocular Hypertension: A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To demonstrate that preoperative treatment for 28 days with topical dorzolamide/timolol is non-inferior (Δ = 4 mm Hg) to oral acetazolamide and topical dexamethasone (standard therapy) in terms of intraocular pressure (IOP) reduction 3 and 6 months after trabeculectomy in glaucoma patients." | 9.24 | Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma. ( Bell, K; Keicher, A; Lorenz, K; Pfeiffer, N; Renieri, G; Ruckes, C; Thieme, H; Wasielica-Poslednik, J, 2017) |
| "To demonstrate that preoperative treatment for 28 days with topical dorzolamide/timolol is non-inferior (Δ = 4 mm Hg) to oral acetazolamide and topical dexamethasone (standard therapy) in terms of intraocular pressure (IOP) reduction 3 and 6 months after trabeculectomy in glaucoma patients." | 5.24 | Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma. ( Bell, K; Keicher, A; Lorenz, K; Pfeiffer, N; Renieri, G; Ruckes, C; Thieme, H; Wasielica-Poslednik, J, 2017) |
| "Others were encapsulated bleb 7." | 1.35 | Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up. ( Ashaye, AO; Komolafe, OO, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lorenz, K | 1 |
| Wasielica-Poslednik, J | 1 |
| Bell, K | 1 |
| Renieri, G | 1 |
| Keicher, A | 1 |
| Ruckes, C | 1 |
| Pfeiffer, N | 1 |
| Thieme, H | 1 |
| Ashaye, AO | 1 |
| Komolafe, OO | 1 |
| Lewandowska-Furmanik, M | 1 |
| Toczołowski, J | 1 |
| Fellman, R | 1 |
| Budenz, D | 1 |
2 trials available for fluorouracil and Ocular Hypertension
| Article | Year |
|---|---|
Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma.
Topics: Acetazolamide; Aged; Antihypertensive Agents; Dexamethasone; Drug Combinations; Female; Fluorouracil | 2017 |
[Use of 5-fluorouracil shortly after trabeculectomy].
Topics: Antimetabolites; Cicatrix; Conjunctiva; Fluorouracil; Humans; Injections; Middle Aged; Ocular Hypert | 1996 |
2 other studies available for fluorouracil and Ocular Hypertension
| Article | Year |
|---|---|
Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up.
Topics: Adult; Aged; Anterior Chamber; Antimetabolites; Blister; Epidemiologic Methods; Female; Fluorouracil | 2009 |
Malignant glaucoma.
Topics: Anterior Chamber; Chronic Disease; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Angle-Closure; | 1999 |