fluorouracil has been researched along with Neuromuscular Blockade in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the characteristics of NMDR induced muscle paralysis in breast cancer patients with and without a history of recent chemotherapy with cyclophosphamide, doxorubicin and 5-fluorouracil (CAF) regimen." | 7.85 | Chemotherapy alters cisatracurium induced neuromuscular blockade characteristics: A prospective cohort study. ( Farokhnia, F; Fazli, M; Khan, ZH; Maghsoudloo, M; Makarem, J; Zanjani, AP, 2017) |
| "To compare the characteristics of NMDR induced muscle paralysis in breast cancer patients with and without a history of recent chemotherapy with cyclophosphamide, doxorubicin and 5-fluorouracil (CAF) regimen." | 3.85 | Chemotherapy alters cisatracurium induced neuromuscular blockade characteristics: A prospective cohort study. ( Farokhnia, F; Fazli, M; Khan, ZH; Maghsoudloo, M; Makarem, J; Zanjani, AP, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zanjani, AP | 1 |
| Maghsoudloo, M | 1 |
| Makarem, J | 1 |
| Farokhnia, F | 1 |
| Fazli, M | 1 |
| Khan, ZH | 1 |
1 other study available for fluorouracil and Neuromuscular Blockade
| Article | Year |
|---|---|
Chemotherapy alters cisatracurium induced neuromuscular blockade characteristics: A prospective cohort study.
Topics: Adult; Anesthesia, General; Antineoplastic Combined Chemotherapy Protocols; Atracurium; Breast Neopl | 2017 |