fluorouracil has been researched along with Neuroleptic Malignant Syndrome in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluorouracil-induced leukoencephalopathy is a rare complication and has been reported to present as confusion, oculomotor abnormality, ataxia, and parkinsonism; however, there is no previous report of a presentation mimicking neuroleptic malignant syndrome." | 8.31 | Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report. ( Hemachudha, P; Phuenpathom, W; Pongpitakmetha, T; Rattanawong, W, 2023) |
| "Fluorouracil-induced leukoencephalopathy is a rare complication and has been reported to present as confusion, oculomotor abnormality, ataxia, and parkinsonism; however, there is no previous report of a presentation mimicking neuroleptic malignant syndrome." | 4.31 | Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report. ( Hemachudha, P; Phuenpathom, W; Pongpitakmetha, T; Rattanawong, W, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hemachudha, P | 1 |
| Rattanawong, W | 1 |
| Pongpitakmetha, T | 1 |
| Phuenpathom, W | 1 |
1 other study available for fluorouracil and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report.
Topics: Aged; Colonic Neoplasms; Fluorouracil; Humans; Leukoencephalopathies; Male; Neuroleptic Malignant Sy | 2023 |