fluorouracil has been researched along with Neuralgia in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-fluorouracil (5-FU) is an antineoplastic drug used to treat colorectal cancer, but it causes, among other adverse effects, diarrhea and mucositis, as well as enteric neuropathy, as shown in experimental animals." | 8.31 | Effect of the Cannabinoid Agonist WIN 55,212-2 on Neuropathic and Visceral Pain Induced by a Non-Diarrheagenic Dose of the Antitumoral Drug 5-Fluorouracil in the Rat. ( Abalo, R; Girón, R; López-Gómez, L; Martín-Fontelles, MI; Nurgali, K; Uranga, JA; Vera, G, 2023) |
| "Taxanes used in adjuvant therapy for breast cancer are neurotoxic, and thereby being a potential risk factor for persistent pain after breast cancer treatment (PPBCT) and sensory disturbances." | 5.38 | Persistent pain, sensory disturbances and functional impairment after adjuvant chemotherapy for breast cancer: cyclophosphamide, epirubicin and fluorouracil compared with docetaxel + epirubicin and cyclophosphamide. ( Andersen, KG; Eckhoff, L; Gärtner, R; Jensen, MB; Kehlet, H; Kroman, N, 2012) |
| "5-fluorouracil (5-FU) is an antineoplastic drug used to treat colorectal cancer, but it causes, among other adverse effects, diarrhea and mucositis, as well as enteric neuropathy, as shown in experimental animals." | 4.31 | Effect of the Cannabinoid Agonist WIN 55,212-2 on Neuropathic and Visceral Pain Induced by a Non-Diarrheagenic Dose of the Antitumoral Drug 5-Fluorouracil in the Rat. ( Abalo, R; Girón, R; López-Gómez, L; Martín-Fontelles, MI; Nurgali, K; Uranga, JA; Vera, G, 2023) |
| "Metastatic pancreatic cancer is one of the leading causes of cancer-related deaths in North America and Europe." | 2.41 | Metastatic pancreatic cancer. ( Kulke, MH, 2002) |
| "Taxanes used in adjuvant therapy for breast cancer are neurotoxic, and thereby being a potential risk factor for persistent pain after breast cancer treatment (PPBCT) and sensory disturbances." | 1.38 | Persistent pain, sensory disturbances and functional impairment after adjuvant chemotherapy for breast cancer: cyclophosphamide, epirubicin and fluorouracil compared with docetaxel + epirubicin and cyclophosphamide. ( Andersen, KG; Eckhoff, L; Gärtner, R; Jensen, MB; Kehlet, H; Kroman, N, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Riganas, S | 1 |
| Papanastasiou, I | 1 |
| Foscolos, GB | 1 |
| Tsotinis, A | 1 |
| Serin, G | 1 |
| Mirjolet, JF | 1 |
| Dimas, K | 1 |
| Kourafalos, VN | 1 |
| Eleutheriades, A | 1 |
| Moutsos, VI | 1 |
| Khan, H | 1 |
| Georgakopoulou, S | 1 |
| Zaniou, A | 1 |
| Prassa, M | 1 |
| Theodoropoulou, M | 1 |
| Mantelas, A | 1 |
| Pondiki, S | 1 |
| Vamvakides, A | 1 |
| Vera, G | 1 |
| López-Gómez, L | 1 |
| Girón, R | 1 |
| Martín-Fontelles, MI | 1 |
| Nurgali, K | 1 |
| Abalo, R | 1 |
| Uranga, JA | 1 |
| Di Cesare Mannelli, L | 1 |
| Maresca, M | 1 |
| Micheli, L | 1 |
| Farina, C | 1 |
| Scherz, MW | 1 |
| Ghelardini, C | 1 |
| Andersen, KG | 1 |
| Jensen, MB | 1 |
| Kehlet, H | 1 |
| Gärtner, R | 1 |
| Eckhoff, L | 1 |
| Kroman, N | 1 |
| Kulke, MH | 1 |
1 review available for fluorouracil and Neuralgia
| Article | Year |
|---|---|
Metastatic pancreatic cancer.
Topics: Antineoplastic Agents; Autonomic Nerve Block; Celiac Plexus; Cholestasis; Clinical Trials as Topic; | 2002 |
4 other studies available for fluorouracil and Neuralgia
| Article | Year |
|---|---|
New adamantane phenylalkylamines with σ-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain.
Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Proliferation; Fe | 2012 |
Effect of the Cannabinoid Agonist WIN 55,212-2 on Neuropathic and Visceral Pain Induced by a Non-Diarrheagenic Dose of the Antitumoral Drug 5-Fluorouracil in the Rat.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Diarrhea; Fluorouracil; Humans; | 2023 |
A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin.
Topics: Administration, Oral; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Fluorouracil; Human | 2017 |
Persistent pain, sensory disturbances and functional impairment after adjuvant chemotherapy for breast cancer: cyclophosphamide, epirubicin and fluorouracil compared with docetaxel + epirubicin and cyclophosphamide.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan | 2012 |