fluorouracil has been researched along with Neoplasms, Trophoblastic in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "From 1979 to 1988, 152 patients with trophoblastic tumor were treated with combination chemotherapy using nitrocaphanum and 5-FU." | 2.69 | Chemotherapy using 5-fluorouracil and nitrocaphanum in malignant trophoblastic tumor. ( Guan, Y; Jiu, L; Qiu, D; Wang, Y, 1998) |
| "Gestational trophoblastic neoplasm treated by large dosage of 5-fluorouracil and actinomycin could cause cardiotoxicity." | 1.29 | [Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies]. ( Qian, H; Wu, Y, 1995) |
| "The mechanism of formation of pseudomembranous colitis, the causative agents and method of diagnosis and treatment were discussed." | 1.28 | [Colitis due to chemotherapeutic agent]. ( Yang, XY, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsui, H | 1 |
| Suzuka, K | 1 |
| Iitsuka, Y | 1 |
| Yamazawa, K | 1 |
| Tanaka, N | 1 |
| Mitsuhashi, A | 1 |
| Seki, K | 1 |
| Sekiya, S | 1 |
| Wang, YX | 1 |
| Zhang, X | 1 |
| Guan, YL | 1 |
| Jang, AY | 1 |
| Long, ZQ | 1 |
| Wang, S | 1 |
| An, R | 1 |
| Han, X | 1 |
| Zhu, K | 1 |
| Xue, Y | 1 |
| Bianconi, M | 1 |
| Jankilevich, G | 1 |
| Otero, S | 1 |
| Nassif, J | 1 |
| Storino, C | 1 |
| Sung, HC | 1 |
| Wu, PC | 1 |
| Wang, YB | 1 |
| Zia, ZF | 1 |
| Wang, YE | 1 |
| Xia, ZF | 1 |
| Wu, Y | 1 |
| Qian, H | 1 |
| Wang, Y | 1 |
| Jiu, L | 1 |
| Guan, Y | 1 |
| Qiu, D | 1 |
| Zhu, L | 1 |
| Song, H | 1 |
| Yang, X | 2 |
| Xiang, Y | 1 |
| Yingna, S | 1 |
| Xiuyu, Y | 1 |
| Hongzhao, S | 1 |
| Yang, XY | 2 |
| Kohorn, EI | 1 |
| Pan, Z | 1 |
| Gui, GF | 1 |
| Li, GR | 1 |
| Bergsagel, DE | 1 |
| Bloomfield, RD | 1 |
3 reviews available for fluorouracil and Neoplasms, Trophoblastic
| Article | Year |
|---|---|
Single-agent chemotherapy for nonmetastatic gestational trophoblastic neoplasia. Perspectives for the 21st century after three decades of use.
Topics: Chorionic Gonadotropin; Dactinomycin; Etoposide; Female; Fluorouracil; Humans; Methotrexate; Pregnan | 1991 |
An assessment of massive-dose chemotherapy of malignant disease.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclo | 1971 |
Current cancer chemotherapy in obstetrics and gynecology.
Topics: Alkaloids; Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Blood Cell Count; Bone Marrow; | 1971 |
1 trial available for fluorouracil and Neoplasms, Trophoblastic
| Article | Year |
|---|---|
Chemotherapy using 5-fluorouracil and nitrocaphanum in malignant trophoblastic tumor.
Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Follow-Up Studies; Humans; Nit | 1998 |
15 other studies available for fluorouracil and Neoplasms, Trophoblastic
| Article | Year |
|---|---|
Salvage combination chemotherapy with 5-fluorouracil and actinomycin D for patients with refractory, high-risk gestational trophoblastic tumors.
Topics: Adult; Dactinomycin; Drug Resistance, Multiple; Female; Fluorouracil; Humans; Leukopenia; Neoplasm R | 2002 |
[Assessment of staging and prognostic scoring system for malignant trophoblastic neoplasia].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Chorionic Gonadotropin; Dact | 2005 |
Combination chemotherapy with 5-fluorouracil, methotrexate and etoposide for patients with high-risk gestational trophoblastic tumors: a report based on our 11-year clinical experiences.
Topics: Antineoplastic Combined Chemotherapy Protocols; China; Drug Resistance, Neoplasm; Etoposide; Female; | 2006 |
Successful salvage of a relapsed high risk gestational trophoblastic neoplasia patient using capecitabine.
Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Choriocarcinoma; Deoxycytidine; Female; Fluoro | 2007 |
Re-evaluation of 5-fluorouracil as a single agent for gestational malignant trophoblastic neoplasms.
Topics: Enterocolitis, Pseudomembranous; Female; Fluorouracil; Follow-Up Studies; Humans; Liver; Pregnancy; | 1984 |
5-Fluorouracil in malignant trophoblastic tumors. report of 350 cases.
Topics: Digestive System; Female; Fluorouracil; Hematopoiesis; Humans; Neoplasm Metastasis; Pregnancy; Troph | 1983 |
[Treatment of malignant trophoblastic tumors with 5-fluorouracil--report of 314 cases].
Topics: Female; Fluorouracil; Humans; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1983 |
[Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiac Output, Low; Chest Pain; Dactinomycin | 1995 |
Pregnancy outcome of patients conceiving within one year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 cases.
Topics: Abortion, Threatened; Adult; Antimetabolites, Antineoplastic; Choriocarcinoma; Female; Fluorouracil; | 1998 |
Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis.
Topics: Angiography; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Choriocarcinoma; Embolization, | 2002 |
[Diagnosis and treatment of hemothorax in malignant trophoblastic tumors].
Topics: Female; Fluorouracil; Hemothorax; Humans; Lung Neoplasms; Pregnancy; Trophoblastic Neoplasms; Uterin | 1992 |
[Nursing care of trophoblastic cell tumor treated with 5-fluorouracil].
Topics: Adult; Female; Fluorouracil; Humans; Middle Aged; Pregnancy; Trophoblastic Neoplasms; Uterine Neopla | 1990 |
[Colitis due to chemotherapeutic agent].
Topics: Adult; Antineoplastic Agents; Enterocolitis; Enterocolitis, Pseudomembranous; Female; Fluorouracil; | 1990 |
[Treatment of the side effects of the chemotherapy of trophoblastic tumor with traditional Chinese medicine and western medicine].
Topics: Adult; Dactinomycin; Female; Fluorouracil; Humans; Leukopenia; Medicine, Chinese Traditional; Medici | 1985 |
[Chromosomal studies in patients with trophoblastic diseases before and after chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Chromosomes, Human, 1-3; Fem | 1986 |