Page last updated: 2024-10-27

fluorouracil and Neoplasms, Otorhinolaryngologic

fluorouracil has been researched along with Neoplasms, Otorhinolaryngologic in 31 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Capecitabine was given twice daily, 7 days a week at a dose starting at 350 mg/m(2) bid."2.71Results of a phase I study to determine the maximum tolerated dose of capecitabine when given concurrently with radical radiotherapy in the treatment of squamous cell carcinoma of the head and neck. ( Ironside, JA; MacDougall, RH; Mais, KL; Slevin, NJ; Sykes, AJ, 2004)
" Radiotherapy was administered twice per day on dosing days 1 through 42 to a total dose of 7200 cGy to the primary tumor and 6000 cGy to the involved lymph nodes."1.31Nodal volume reduction after concurrent chemo- and radiotherapy: correlation between initial CT and histopathologic findings. ( Labadie, RF; Mukherji, SK; Pillsbury, HC; Weissler, MC; Yarbrough, WG, 2000)
"Neoadjuvant chemotherapy in Hodgkin's disease has improved survival time and tolerance to irradiation, allowing a lowering of the total doses used and the volumes irradiated."1.28[Radiotherapy with neoadjuvant chemotherapy]. ( Alapetite, C; Baillet, F; Dessard-Diana, B; Housset, M; Jacquillat, C; Michel-Langlet, P, 1989)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19908 (25.81)18.7374
1990's5 (16.13)18.2507
2000's10 (32.26)29.6817
2010's8 (25.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Loriot, MA1
Masskouri, F1
Carni, P1
Le Malicot, K1
Seitz, JF1
Michel, P1
Legoux, JL1
Bouché, O1
André, T1
Faroux, R1
Delaloge, S1
Malka, D1
Guigay, J1
Thariat, J1
Thomas, F1
Barin-Le-Guellec, C1
Ciccolini, J1
Boyer, JC1
Étienne-Grimaldi, MC1
Budach, V1
Becker, ET1
Boehmer, D1
Badakhshi, H1
Jahn, U1
Wernecke, KD1
Stromberger, C1
Balermpas, P1
Bauer, C1
Fraunholz, I1
Ottinger, A1
Wagenblast, J1
Stöver, T1
Seitz, O1
Fokas, E1
Rödel, C1
Weiss, C1
da Costa, AA1
D'Almeida Costa, F1
Ribeiro, AR1
Guimarães, AP1
Chinen, LT1
Lopes, CA1
de Lima, VC1
Takácsi-Nagy, Z1
Hitre, E1
Remenár, É1
Oberna, F1
Polgár, C1
Major, T1
Gödény, M1
Fodor, J1
Kásler, M1
Tribius, S1
Kronemann, S1
Kilic, Y1
Schroeder, U1
Hakim, S1
Schild, SE1
Rades, D1
Mumme, AM1
Reitmeier, F1
Knecht, R1
Habl, G1
Jensen, AD1
Potthoff, K1
Uhl, M1
Hof, H1
Hajda, J1
Simon, C1
Debus, J1
Krempien, R1
Münter, MW1
Tabor, MH1
Clay, MR1
Owen, JH1
Bradford, CR1
Carey, TE1
Wolf, GT1
Prince, ME1
Hehr, T1
Classen, J1
Schreck, U1
Glocker, S1
Koitschev, A1
Bamberg, M1
Budach, W1
Pulcini, C1
Vandenbos, F1
Bernard, E1
Roth, S1
Elbeze, JP1
Dunais, B1
Peyrade, F1
Dellamonica, P1
Sykes, AJ1
Slevin, NJ1
MacDougall, RH1
Ironside, JA1
Mais, KL1
Tsukuda, M1
Mikami, Y1
Tanigaki, Y1
Katori, H1
Horiuchi, C1
Ikeda, Y1
Taguchi, T1
Ono, M1
Yoshida, T1
Sakuma, Y1
Aikoh, K1
Dequanter, D1
Lothaire, P1
Awada, A1
Lalami, Y1
Hien Nguyen, T1
Lemort, M1
Vandevelde, L1
Andry, G1
Maylin, C1
Walter, S1
Hennequin, C1
Brette, MD1
Durdux, C1
Monteil, JP1
Deboise, A1
Vanselow, B1
Dietz, A1
Rudat, V1
Wollensack, P1
Bettscheider, C1
Eble, MJ1
Lütolf, UM1
Labadie, RF1
Yarbrough, WG1
Weissler, MC1
Pillsbury, HC1
Mukherji, SK1
León, X1
Quer, M1
Orús, C1
de Dios, E1
Recher, K1
Heib, C1
Schmidt, HJ1
Heib, T1
Lüer, B1
Stasche, N1
Munker, R1
Purmale, L1
Aydemir, U1
Reitmeier, M1
Pohlmann, H1
Schorer, H1
Hartenstein, R1
Volling, P1
Stryker, JA1
Harvey, HA1
Houck, JR1
Manders, EK1
Bradfield, JJ1
Ayadi, A1
Bassot, V3
Donnadieu, S2
Brasnu, D2
Laccourreye, M1
Baillet, F1
Housset, M1
Dessard-Diana, B1
Jacquillat, C1
Michel-Langlet, P1
Alapetite, C1
Santini, J1
Dassonville, O1
Serra, C1
Falewee, MN1
Darcourt, J1
Schneider, M1
Demard, F1
Ménard, M1
Janot, F1
Fabre, A1
Laccourreye, H1
Cachin, Y1
Domenge, C1
Jakse, R2
Scherlacher, A2
Lehnert, M2
Haas, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacogenetic and Pharmacokinetic Aspects of the Response to Chemotherapy Induction Using Docetaxel, Cisplatin and 5-Fluorouracile (TPF)in ORL Cancers[NCT01104714]90 participants (Actual)Observational2010-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for fluorouracil and Neoplasms, Otorhinolaryngologic

ArticleYear
[The current value of induction chemotherapy. ASCO Congress 2010].
    HNO, 2010, Volume: 58, Issue:12

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot

2010
[The status of sequential chemo-/radiotherapy in inoperable head and neck cancers. Personal results and review of the literature].
    HNO, 1991, Volume: 39, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;

1991

Trials

8 trials available for fluorouracil and Neoplasms, Otorhinolaryngologic

ArticleYear
Concurrent hyperfractionated accelerated radiotherapy with 5-FU and once weekly cisplatin in locally advanced head and neck cancer. The 10-year results of a prospective phase II trial.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2014, Volume: 190, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe

2014
Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage III-IV unresectable head and neck cancer: Results of a randomized phase II study.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2015, Volume: 191, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe

2015
Treatment of locally advanced carcinomas of head and neck with intensity-modulated radiation therapy (IMRT) in combination with cetuximab and chemotherapy: the REACH protocol.
    BMC cancer, 2010, Nov-26, Volume: 10

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot

2010
Selective lymph node dissection following hyperfractionated accelerated radio-(chemo-)therapy for advanced head and neck cancer.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2002, Volume: 178, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous

2002
Results of a phase I study to determine the maximum tolerated dose of capecitabine when given concurrently with radical radiotherapy in the treatment of squamous cell carcinoma of the head and neck.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 71, Issue:1

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Combi

2004
Phase I trial of combined chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for patients with locally advanced squamous cell carcinoma of the head and neck.
    International journal of clinical oncology, 2004, Volume: 9, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Docetaxel

2004
[Radio-chemotherapy. Is it of value in tumors of the otorhinolaryngology region?].
    HNO, 1998, Volume: 46, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Dose Fractiona

1998
[The status of sequential chemo-/radiotherapy in inoperable head and neck cancers. Personal results and review of the literature].
    HNO, 1991, Volume: 39, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;

1991

Other Studies

22 other studies available for fluorouracil and Neoplasms, Otorhinolaryngologic

ArticleYear
[Dihydropyrimidine dehydrogenase deficiency screening for management of patients receiving a fluoropyrimidine: Results of two national practice surveys addressed to clinicians and biologists].
    Bulletin du cancer, 2019, Volume: 106, Issue:9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biology; Biomedical

2019
Concomitant chemoradiotherapy versus induction chemotherapy followed by chemoradiotherapy as definitive, first line treatment of squamous cell carcinoma of the head and neck. A retrospective single center analysis.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2014, Volume: 190, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; C

2014
Low PTEN expression is associated with worse overall survival in head and neck squamous cell carcinoma patients treated with chemotherapy and cetuximab.
    International journal of clinical oncology, 2015, Volume: 20, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; C

2015
Radiochemotherapy including cisplatin alone versus cisplatin + 5-fluorouracil for locally advanced unresectable stage IV squamous cell carcinoma of the head and neck.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2009, Volume: 185, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Ci

2009
Head and neck cancer stem cells: the side population.
    The Laryngoscope, 2011, Volume: 121, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor;

2011
[Diagnosis of a metastatic valvular tumor in a living patient].
    La Revue de medecine interne, 2003, Volume: 24, Issue:5

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Ischemia; Car

2003
Does clinical and radiological response predict complete tumor control in N2-N3 squamous cell head and neck cancer after non-operative management of the neck?
    Acta oto-laryngologica, 2006, Volume: 126, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcino

2006
[Concomitant radiochemotherapy in locally advanced ORL cancers: a prospective study of 68 cases].
    Bulletin du cancer. Radiotherapie : journal de la Societe francaise du cancer : organe de la societe francaise de radiotherapie oncologique, 1996, Volume: 83, Issue:2

    Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous

1996
[Polarographic detection of reoxygenation of lymph node metastases in the initial phase of primary radio- and radiochemotherapy in patients with advanced squamous epithelial carcinomas of the head and neck].
    HNO, 1997, Volume: 45, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;

1997
Nodal volume reduction after concurrent chemo- and radiotherapy: correlation between initial CT and histopathologic findings.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined

2000
Treatment of neck nodes after induction chemotherapy in patients with primary advanced tumours.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2000, Volume: 257, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali

2000
[Cardiotoxicity of 5-fluorouracil. Clinical relevance of palliative radiochemotherapy of malignant head-neck tumors].
    Laryngo- rhino- otologie, 2001, Volume: 80, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Coronary Vasospasm; Fluor

2001
Advanced head and neck cancer: long-term results of chemo-radiotherapy, complications and induction of second malignancies.
    Onkologie, 2001, Volume: 24, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cobalt Radioisotopes; Combined Moda

2001
Advanced head and neck cancer: low-dose, split-course radiation therapy and simultaneous infusion of 5-fluorouracil and cisplatin.
    Radiology, 1990, Volume: 176, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Female; Fluoro

1990
[Early death after chemotherapy via central venous catheterization in tumors of the upper respiratory and digestive tracts].
    Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1989, Volume: 106, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Catheterization, Central Venous; Ca

1989
[Radiotherapy with neoadjuvant chemotherapy].
    Annales de medecine interne, 1989, Volume: 140, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Doxorub

1989
[Intra-arterial chemotherapy of ORL cancer. Value of an implantable infusion system and scintigraphic monitoring].
    Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1989, Volume: 106, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Female; Fluorou

1989
[Continuous ambulatory chemotherapy in cancer of the upper respiratory and digestive tract].
    Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1988, Volume: 105, Issue:6

    Topics: Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Fluorouracil; Follow-Up

1988
[Chemotherapy of ORL cancers].
    Revue de l'infirmiere, 1988, Volume: 38, Issue:16

    Topics: Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Fluorouracil; Humans;

1988
[Chemotherapy of carcinoma of the upper respiratory and digestive tract].
    Revue de laryngologie - otologie - rhinologie, 1986, Volume: 107, Issue:1

    Topics: Cisplatin; Combined Modality Therapy; Digestive System Neoplasms; Fluorouracil; Humans; Otorhinolary

1986
[Chemotherapy of recurrent squamous cell carcinomas in the ENT area with cisplatin/adriamycin (DDP/ADM) and methotrexate/5-fluorouracil (MTX/5-Flu): a retrospective comparison of 2 protocols].
    HNO, 1986, Volume: 34, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Co

1986
[Therapy of recurrent squamous cell cancers in the ENT area with the sequential methotrexate (MTX)/5-fluorouracil (5-Fu) protocol].
    Laryngologie, Rhinologie, Otologie, 1985, Volume: 64, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Female; Fluor

1985