fluorouracil has been researched along with Neoplasms, Otorhinolaryngologic in 31 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Capecitabine was given twice daily, 7 days a week at a dose starting at 350 mg/m(2) bid." | 2.71 | Results of a phase I study to determine the maximum tolerated dose of capecitabine when given concurrently with radical radiotherapy in the treatment of squamous cell carcinoma of the head and neck. ( Ironside, JA; MacDougall, RH; Mais, KL; Slevin, NJ; Sykes, AJ, 2004) |
| " Radiotherapy was administered twice per day on dosing days 1 through 42 to a total dose of 7200 cGy to the primary tumor and 6000 cGy to the involved lymph nodes." | 1.31 | Nodal volume reduction after concurrent chemo- and radiotherapy: correlation between initial CT and histopathologic findings. ( Labadie, RF; Mukherji, SK; Pillsbury, HC; Weissler, MC; Yarbrough, WG, 2000) |
| "Neoadjuvant chemotherapy in Hodgkin's disease has improved survival time and tolerance to irradiation, allowing a lowering of the total doses used and the volumes irradiated." | 1.28 | [Radiotherapy with neoadjuvant chemotherapy]. ( Alapetite, C; Baillet, F; Dessard-Diana, B; Housset, M; Jacquillat, C; Michel-Langlet, P, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (25.81) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 8 (25.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loriot, MA | 1 |
| Masskouri, F | 1 |
| Carni, P | 1 |
| Le Malicot, K | 1 |
| Seitz, JF | 1 |
| Michel, P | 1 |
| Legoux, JL | 1 |
| Bouché, O | 1 |
| André, T | 1 |
| Faroux, R | 1 |
| Delaloge, S | 1 |
| Malka, D | 1 |
| Guigay, J | 1 |
| Thariat, J | 1 |
| Thomas, F | 1 |
| Barin-Le-Guellec, C | 1 |
| Ciccolini, J | 1 |
| Boyer, JC | 1 |
| Étienne-Grimaldi, MC | 1 |
| Budach, V | 1 |
| Becker, ET | 1 |
| Boehmer, D | 1 |
| Badakhshi, H | 1 |
| Jahn, U | 1 |
| Wernecke, KD | 1 |
| Stromberger, C | 1 |
| Balermpas, P | 1 |
| Bauer, C | 1 |
| Fraunholz, I | 1 |
| Ottinger, A | 1 |
| Wagenblast, J | 1 |
| Stöver, T | 1 |
| Seitz, O | 1 |
| Fokas, E | 1 |
| Rödel, C | 1 |
| Weiss, C | 1 |
| da Costa, AA | 1 |
| D'Almeida Costa, F | 1 |
| Ribeiro, AR | 1 |
| Guimarães, AP | 1 |
| Chinen, LT | 1 |
| Lopes, CA | 1 |
| de Lima, VC | 1 |
| Takácsi-Nagy, Z | 1 |
| Hitre, E | 1 |
| Remenár, É | 1 |
| Oberna, F | 1 |
| Polgár, C | 1 |
| Major, T | 1 |
| Gödény, M | 1 |
| Fodor, J | 1 |
| Kásler, M | 1 |
| Tribius, S | 1 |
| Kronemann, S | 1 |
| Kilic, Y | 1 |
| Schroeder, U | 1 |
| Hakim, S | 1 |
| Schild, SE | 1 |
| Rades, D | 1 |
| Mumme, AM | 1 |
| Reitmeier, F | 1 |
| Knecht, R | 1 |
| Habl, G | 1 |
| Jensen, AD | 1 |
| Potthoff, K | 1 |
| Uhl, M | 1 |
| Hof, H | 1 |
| Hajda, J | 1 |
| Simon, C | 1 |
| Debus, J | 1 |
| Krempien, R | 1 |
| Münter, MW | 1 |
| Tabor, MH | 1 |
| Clay, MR | 1 |
| Owen, JH | 1 |
| Bradford, CR | 1 |
| Carey, TE | 1 |
| Wolf, GT | 1 |
| Prince, ME | 1 |
| Hehr, T | 1 |
| Classen, J | 1 |
| Schreck, U | 1 |
| Glocker, S | 1 |
| Koitschev, A | 1 |
| Bamberg, M | 1 |
| Budach, W | 1 |
| Pulcini, C | 1 |
| Vandenbos, F | 1 |
| Bernard, E | 1 |
| Roth, S | 1 |
| Elbeze, JP | 1 |
| Dunais, B | 1 |
| Peyrade, F | 1 |
| Dellamonica, P | 1 |
| Sykes, AJ | 1 |
| Slevin, NJ | 1 |
| MacDougall, RH | 1 |
| Ironside, JA | 1 |
| Mais, KL | 1 |
| Tsukuda, M | 1 |
| Mikami, Y | 1 |
| Tanigaki, Y | 1 |
| Katori, H | 1 |
| Horiuchi, C | 1 |
| Ikeda, Y | 1 |
| Taguchi, T | 1 |
| Ono, M | 1 |
| Yoshida, T | 1 |
| Sakuma, Y | 1 |
| Aikoh, K | 1 |
| Dequanter, D | 1 |
| Lothaire, P | 1 |
| Awada, A | 1 |
| Lalami, Y | 1 |
| Hien Nguyen, T | 1 |
| Lemort, M | 1 |
| Vandevelde, L | 1 |
| Andry, G | 1 |
| Maylin, C | 1 |
| Walter, S | 1 |
| Hennequin, C | 1 |
| Brette, MD | 1 |
| Durdux, C | 1 |
| Monteil, JP | 1 |
| Deboise, A | 1 |
| Vanselow, B | 1 |
| Dietz, A | 1 |
| Rudat, V | 1 |
| Wollensack, P | 1 |
| Bettscheider, C | 1 |
| Eble, MJ | 1 |
| Lütolf, UM | 1 |
| Labadie, RF | 1 |
| Yarbrough, WG | 1 |
| Weissler, MC | 1 |
| Pillsbury, HC | 1 |
| Mukherji, SK | 1 |
| León, X | 1 |
| Quer, M | 1 |
| Orús, C | 1 |
| de Dios, E | 1 |
| Recher, K | 1 |
| Heib, C | 1 |
| Schmidt, HJ | 1 |
| Heib, T | 1 |
| Lüer, B | 1 |
| Stasche, N | 1 |
| Munker, R | 1 |
| Purmale, L | 1 |
| Aydemir, U | 1 |
| Reitmeier, M | 1 |
| Pohlmann, H | 1 |
| Schorer, H | 1 |
| Hartenstein, R | 1 |
| Volling, P | 1 |
| Stryker, JA | 1 |
| Harvey, HA | 1 |
| Houck, JR | 1 |
| Manders, EK | 1 |
| Bradfield, JJ | 1 |
| Ayadi, A | 1 |
| Bassot, V | 3 |
| Donnadieu, S | 2 |
| Brasnu, D | 2 |
| Laccourreye, M | 1 |
| Baillet, F | 1 |
| Housset, M | 1 |
| Dessard-Diana, B | 1 |
| Jacquillat, C | 1 |
| Michel-Langlet, P | 1 |
| Alapetite, C | 1 |
| Santini, J | 1 |
| Dassonville, O | 1 |
| Serra, C | 1 |
| Falewee, MN | 1 |
| Darcourt, J | 1 |
| Schneider, M | 1 |
| Demard, F | 1 |
| Ménard, M | 1 |
| Janot, F | 1 |
| Fabre, A | 1 |
| Laccourreye, H | 1 |
| Cachin, Y | 1 |
| Domenge, C | 1 |
| Jakse, R | 2 |
| Scherlacher, A | 2 |
| Lehnert, M | 2 |
| Haas, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenetic and Pharmacokinetic Aspects of the Response to Chemotherapy Induction Using Docetaxel, Cisplatin and 5-Fluorouracile (TPF)in ORL Cancers[NCT01104714] | 90 participants (Actual) | Observational | 2010-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Neoplasms, Otorhinolaryngologic
| Article | Year |
|---|---|
[The current value of induction chemotherapy. ASCO Congress 2010].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot | 2010 |
[The status of sequential chemo-/radiotherapy in inoperable head and neck cancers. Personal results and review of the literature].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; | 1991 |
8 trials available for fluorouracil and Neoplasms, Otorhinolaryngologic
| Article | Year |
|---|---|
Concurrent hyperfractionated accelerated radiotherapy with 5-FU and once weekly cisplatin in locally advanced head and neck cancer. The 10-year results of a prospective phase II trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe | 2014 |
Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage III-IV unresectable head and neck cancer: Results of a randomized phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe | 2015 |
Treatment of locally advanced carcinomas of head and neck with intensity-modulated radiation therapy (IMRT) in combination with cetuximab and chemotherapy: the REACH protocol.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot | 2010 |
Selective lymph node dissection following hyperfractionated accelerated radio-(chemo-)therapy for advanced head and neck cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 2002 |
Results of a phase I study to determine the maximum tolerated dose of capecitabine when given concurrently with radical radiotherapy in the treatment of squamous cell carcinoma of the head and neck.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Combi | 2004 |
Phase I trial of combined chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for patients with locally advanced squamous cell carcinoma of the head and neck.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Docetaxel | 2004 |
[Radio-chemotherapy. Is it of value in tumors of the otorhinolaryngology region?].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Dose Fractiona | 1998 |
[The status of sequential chemo-/radiotherapy in inoperable head and neck cancers. Personal results and review of the literature].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; | 1991 |
22 other studies available for fluorouracil and Neoplasms, Otorhinolaryngologic
| Article | Year |
|---|---|
[Dihydropyrimidine dehydrogenase deficiency screening for management of patients receiving a fluoropyrimidine: Results of two national practice surveys addressed to clinicians and biologists].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biology; Biomedical | 2019 |
Concomitant chemoradiotherapy versus induction chemotherapy followed by chemoradiotherapy as definitive, first line treatment of squamous cell carcinoma of the head and neck. A retrospective single center analysis.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; C | 2014 |
Low PTEN expression is associated with worse overall survival in head and neck squamous cell carcinoma patients treated with chemotherapy and cetuximab.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; C | 2015 |
Radiochemotherapy including cisplatin alone versus cisplatin + 5-fluorouracil for locally advanced unresectable stage IV squamous cell carcinoma of the head and neck.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Ci | 2009 |
Head and neck cancer stem cells: the side population.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; | 2011 |
[Diagnosis of a metastatic valvular tumor in a living patient].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Ischemia; Car | 2003 |
Does clinical and radiological response predict complete tumor control in N2-N3 squamous cell head and neck cancer after non-operative management of the neck?
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcino | 2006 |
[Concomitant radiochemotherapy in locally advanced ORL cancers: a prospective study of 68 cases].
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 1996 |
[Polarographic detection of reoxygenation of lymph node metastases in the initial phase of primary radio- and radiochemotherapy in patients with advanced squamous epithelial carcinomas of the head and neck].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; | 1997 |
Nodal volume reduction after concurrent chemo- and radiotherapy: correlation between initial CT and histopathologic findings.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined | 2000 |
Treatment of neck nodes after induction chemotherapy in patients with primary advanced tumours.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali | 2000 |
[Cardiotoxicity of 5-fluorouracil. Clinical relevance of palliative radiochemotherapy of malignant head-neck tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Coronary Vasospasm; Fluor | 2001 |
Advanced head and neck cancer: long-term results of chemo-radiotherapy, complications and induction of second malignancies.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cobalt Radioisotopes; Combined Moda | 2001 |
Advanced head and neck cancer: low-dose, split-course radiation therapy and simultaneous infusion of 5-fluorouracil and cisplatin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Female; Fluoro | 1990 |
[Early death after chemotherapy via central venous catheterization in tumors of the upper respiratory and digestive tracts].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Catheterization, Central Venous; Ca | 1989 |
[Radiotherapy with neoadjuvant chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Doxorub | 1989 |
[Intra-arterial chemotherapy of ORL cancer. Value of an implantable infusion system and scintigraphic monitoring].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Female; Fluorou | 1989 |
[Continuous ambulatory chemotherapy in cancer of the upper respiratory and digestive tract].
Topics: Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Fluorouracil; Follow-Up | 1988 |
[Chemotherapy of ORL cancers].
Topics: Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Fluorouracil; Humans; | 1988 |
[Chemotherapy of carcinoma of the upper respiratory and digestive tract].
Topics: Cisplatin; Combined Modality Therapy; Digestive System Neoplasms; Fluorouracil; Humans; Otorhinolary | 1986 |
[Chemotherapy of recurrent squamous cell carcinomas in the ENT area with cisplatin/adriamycin (DDP/ADM) and methotrexate/5-fluorouracil (MTX/5-Flu): a retrospective comparison of 2 protocols].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Co | 1986 |
[Therapy of recurrent squamous cell cancers in the ENT area with the sequential methotrexate (MTX)/5-fluorouracil (5-Fu) protocol].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Female; Fluor | 1985 |