fluorouracil has been researched along with Neoplasm Seeding in 24 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Neoplasm Seeding: The local implantation of tumor cells by contamination of instruments and surgical equipment during and after surgical resection, resulting in local growth of the cells and tumor formation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We herein report the result of a prospective study to investigate the efficacy of cimetidine administration in conjunction with chemotherapy for stage IV colorectal cancer." | 7.72 | [Effect of cimetidine with chemotherapy on stage IV colorectal cancer]. ( Fujimoto, T; Hashimoto, M; Ishibashi, K; Iwasaki, K; Ogawa, K; Umehara, A; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2003) |
| "We herein report the result of a prospective study to investigate the efficacy of cimetidine administration in conjunction with chemotherapy for stage IV colorectal cancer." | 3.72 | [Effect of cimetidine with chemotherapy on stage IV colorectal cancer]. ( Fujimoto, T; Hashimoto, M; Ishibashi, K; Iwasaki, K; Ogawa, K; Umehara, A; Yokomizo, H; Yoshida, K; Yoshimatsu, K, 2003) |
| "Use of chlorhexidine intraperitoneal therapy at the time of the operation for perforated colorectal cancer significantly decreases the frequency of gross tumor recurrence but not total recurrences." | 3.69 | Use of intraperitoneal 5-fluorouracil and chlorhexidine for prevention of recurrence of perforated colorectal carcinoma in a rat model. ( Ong, J; Stabile, B; Stamos, M; Stuntz, M; Wilmoth, G, 1997) |
| "Clinicopathological data of 257 cM1 gastric cancer patients who underwent an operation at Seoul National University Hospital from January 1999 to December 2004 were reviewed." | 1.38 | The value of palliative gastrectomy in gastric cancer with distant metastasis. ( Chang, YR; Han, DS; Kim, SH; Kim, WH; Kong, SH; Lee, HJ; Yang, HK, 2012) |
| " As adverse effects of the following systemic chemotherapy, three patients had grade 3 anemia and one had grade 3 leukopenia." | 1.33 | [Safety and efficacy of hypotonic CDDP intraperitoneal administration for gastric cancer with peritoneal dissemination]. ( Bamba, T; Hanyu, T; Hatakeyama, K; Ishikawa, T; Kanda, T; Kosugi, S; Makino, S; Ohashi, M; Sakamoto, K; Tanabe, T; Yajima, K, 2005) |
| "Pseudomyxoma peritonei is a rare disease caused by a perforated adenoma of the appendix." | 1.29 | Patterns of failure following treatment of pseudomyxoma peritonei of appendiceal origin. ( Sugarbaker, PH; Zoetmulder, FA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shimizu, T | 1 |
| Sonoda, H | 1 |
| Murata, S | 1 |
| Takebayashi, K | 1 |
| Ohta, H | 1 |
| Miyake, T | 1 |
| Mekata, E | 1 |
| Shiomi, H | 1 |
| Naka, S | 1 |
| Tani, T | 1 |
| Azad, A | 1 |
| Chionh, F | 1 |
| Jayarajan, J | 1 |
| Hasegawa, K | 1 |
| Matsumoto, R | 1 |
| Yamada, H | 1 |
| Kuroda, T | 1 |
| Mamiya, Y | 1 |
| Kon, A | 1 |
| Quenet, F | 1 |
| Goéré, D | 2 |
| Mehta, SS | 1 |
| Roca, L | 1 |
| Dumont, F | 1 |
| Hessissen, M | 1 |
| Saint-Aubert, B | 1 |
| Elias, D | 2 |
| Chang, YR | 1 |
| Han, DS | 1 |
| Kong, SH | 1 |
| Lee, HJ | 1 |
| Kim, SH | 1 |
| Kim, WH | 1 |
| Yang, HK | 1 |
| Zhuchenko, AP | 1 |
| Kalganov, ID | 1 |
| Filon, AF | 1 |
| Yoshimatsu, K | 1 |
| Ishibashi, K | 1 |
| Hashimoto, M | 1 |
| Umehara, A | 1 |
| Yokomizo, H | 1 |
| Yoshida, K | 1 |
| Fujimoto, T | 1 |
| Iwasaki, K | 1 |
| Ogawa, K | 1 |
| Tamesa, T | 1 |
| Watanabe, Y | 1 |
| Yoshimura, K | 1 |
| Mori, N | 1 |
| Yamamoto, S | 1 |
| Hazama, S | 1 |
| Tangoku, A | 1 |
| Oka, M | 1 |
| Yonemura, Y | 1 |
| Endou, Y | 1 |
| Tochiori, S | 1 |
| Bando, E | 1 |
| Kawamura, T | 1 |
| Shimada, T | 1 |
| Miyamoto, K | 1 |
| Tanaka, M | 1 |
| Sasaki, T | 1 |
| Bamba, T | 1 |
| Kanda, T | 1 |
| Ohashi, M | 1 |
| Hanyu, T | 1 |
| Sakamoto, K | 1 |
| Ishikawa, T | 1 |
| Yajima, K | 1 |
| Makino, S | 1 |
| Tanabe, T | 1 |
| Kosugi, S | 1 |
| Hatakeyama, K | 1 |
| Koppe, MJ | 1 |
| Boerman, OC | 1 |
| Oyen, WJ | 1 |
| Bleichrodt, RP | 1 |
| Tulunay, OE | 1 |
| Enamorado, II | 1 |
| Kucuk, O | 1 |
| Heilbrun, LK | 1 |
| Otero, JE | 1 |
| Korkmaz, H | 1 |
| Blumberg, R | 1 |
| Jacobs, JR | 1 |
| Di Pietrantonio, D | 1 |
| Boulet, T | 1 |
| Honore, C | 1 |
| Bonnet, S | 1 |
| Kohneh-Shahri, N | 1 |
| Raynard, B | 1 |
| Yamagata, S | 1 |
| Unno, T | 1 |
| Yamamoto, K | 1 |
| Sugawa, T | 1 |
| Tattersall, MH | 1 |
| Zoetmulder, FA | 1 |
| Sugarbaker, PH | 1 |
| Stuntz, M | 1 |
| Wilmoth, G | 1 |
| Ong, J | 1 |
| Stabile, B | 1 |
| Stamos, M | 1 |
| O'Hagan, S | 1 |
| Diamond, T | 1 |
| Eshraghi, N | 1 |
| Swanstrom, LL | 1 |
| Bax, T | 1 |
| Jobe, B | 1 |
| Horvath, K | 1 |
| Sheppard, B | 1 |
| Deveney, C | 1 |
| Poser, H | 1 |
| Quäck, J | 1 |
| Jacobsen, J | 1 |
| Prorokov, VV | 1 |
| Ozhiganov, EL | 1 |
| Abramova, NA | 1 |
| Lokich, JJ | 1 |
| Brooks, JR | 1 |
| Ellis, H | 1 |
| Fortner, JG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BEV-IP: Perioperative Chemotherapy With Bevacizumab in Patients Undergoing Cytoreduction and Intraperitoneal Chemoperfusion for Colorectal Carcinomatosis[NCT02399410] | Phase 2 | 60 participants (Actual) | Interventional | 2015-12-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluorouracil and Neoplasm Seeding
| Article | Year |
|---|---|
Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies.
Topics: Antineoplastic Agents; Carcinoma; Colorectal Neoplasms; Combined Modality Therapy; Fluorouracil; Hum | 2006 |
[Treatment possibilities of laryngeal cancer. Surgery--radiotherapy--chemotherapy].
Topics: Antineoplastic Agents; Cell Transformation, Neoplastic; Chemotherapy, Cancer, Regional Perfusion; Co | 1975 |
[Adjuvant chemotherapy following radical operations for cancer of the large intestine].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Com | 1985 |
Recent advances in pancreatic cancer.
Topics: Adenocarcinoma; Angiography; Antigens, Neoplasm; Biopsy; Carcinoembryonic Antigen; Endoscopy; Evalua | 1974 |
3 trials available for fluorouracil and Neoplasm Seeding
| Article | Year |
|---|---|
Hyperthermic intraperitoneal chemotherapy using a combination of mitomycin C,5-fluorouracil, and oxaliplatin in patients at high risk of colorectal peritoneal metastasis: A Phase I clinical study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Colorectal Neo | 2014 |
[Cytoreductive surgery with intraperitoneal chemotherapy in patients with colon cancer and peritoneal carcinomatosis].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Combined | 2003 |
[Adjuvant chemotherapy following radical operations for cancer of the large intestine].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Com | 1985 |
18 other studies available for fluorouracil and Neoplasm Seeding
| Article | Year |
|---|---|
Gallbladder squamous cell carcinoma in the setting of low-dose methotrexate use.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cholecystectomy, Lap | 2009 |
[A case of sigmoid colon carcinoma accompanied with hydronephrosis caused by peritoneal dissemination and para-aortic lymph node metastases markedly responded to chemotherapy].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C | 2009 |
Results of two bi-institutional prospective studies using intraperitoneal oxaliplatin with or without irinotecan during HIPEC after cytoreductive surgery for colorectal carcinomatosis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; C | 2011 |
The value of palliative gastrectomy in gastric cancer with distant metastasis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Female; Fluoroura | 2012 |
[Effect of cimetidine with chemotherapy on stage IV colorectal cancer].
Topics: Adjuvants, Immunologic; Aged; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colorectal | 2003 |
[A case of disseminated tumor from cecal cancer with survival for over 5 years after twice surgical resection and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic | 2004 |
[Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer].
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carboplatin; Cisplatin; Docetaxel; | 2005 |
[Safety and efficacy of hypotonic CDDP intraperitoneal administration for gastric cancer with peritoneal dissemination].
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Cisplatin; Drug Administration Schedule; Drug Therapy, | 2005 |
Pilot study of intraoperative chemotherapy with cisplatin and 5-fluorouracil in patients with advanced squamous cell carcinoma of the head and neck.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined | 2007 |
"Natural history" of complete cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Disease Progression; Drainage; | 2009 |
[Long-term maintenance chemotherapy for pseudomyxoma peritonei of ovarian origin].
Topics: Aged; Cyclophosphamide; Female; Fluorouracil; Humans; Hysterectomy; Middle Aged; Neoplasm Seeding; O | 1984 |
Chemotherapy in gastric and oesophageal cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Squamous Cell; Doxorubicin; Drug Therapy, Combinat | 1982 |
Patterns of failure following treatment of pseudomyxoma peritonei of appendiceal origin.
Topics: Abdomen; Adult; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Chemotherapy, | 1996 |
Use of intraperitoneal 5-fluorouracil and chlorhexidine for prevention of recurrence of perforated colorectal carcinoma in a rat model.
Topics: Animals; Anti-Infective Agents, Local; Antimetabolites, Antineoplastic; Chlorhexidine; Colorectal Ne | 1997 |
Cutaneous metastasis as a complication of hepatic intra-arterial chemotherapy.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorourac | 1997 |
Topical treatments of laparoscopic port sites can decrease the incidence of incision metastasis.
Topics: Administration, Topical; Animals; Colectomy; Colonic Neoplasms; Female; Fluorouracil; Laparoscopy; M | 1999 |
Disappearance of disseminated pancreatic carcinoma with combined chemotherapy.
Topics: Adult; Carcinoma, Intraductal, Noninfiltrating; Carmustine; Duodenum; Fluorouracil; Gastrectomy; Hum | 1973 |
Prevention of recurrent cancer of the large bowel.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Large; Ligati | 1974 |