fluorouracil has been researched along with Necrotizing Enterocolitis in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "At increasing use of high-dose 5-fluorouracil-based chemotherapy for metastatic colorectal and gastric cancer complicated drug-induced colitis is observed more frequently." | 7.71 | [5-Fluorouracil-induced colitis--a review based upon consideration of 6 cases]. ( Hotz, J; Madisch, A; Marquard, F; Stolte, M; Wiedbrauck, F, 2002) |
| "At increasing use of high-dose 5-fluorouracil-based chemotherapy for metastatic colorectal and gastric cancer complicated drug-induced colitis is observed more frequently." | 3.71 | [5-Fluorouracil-induced colitis--a review based upon consideration of 6 cases]. ( Hotz, J; Madisch, A; Marquard, F; Stolte, M; Wiedbrauck, F, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Madisch, A | 1 |
| Wiedbrauck, F | 1 |
| Marquard, F | 1 |
| Stolte, M | 1 |
| Hotz, J | 1 |
1 other study available for fluorouracil and Necrotizing Enterocolitis
| Article | Year |
|---|---|
[5-Fluorouracil-induced colitis--a review based upon consideration of 6 cases].
Topics: Aged; Colitis; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; | 2002 |