fluorouracil has been researched along with Nail Diseases in 35 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Nail Diseases: Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To compare the efficacy and safety of intralesional injection of 5-fluorouracil (5-FU), methotrexate (MTX), triamcinolone acetonide (TA) versus topical calcipotriol plus urea 20% in the treatment of nail psoriasis." | 9.51 | Topical calcipotriol combined with urea 20% versus intralesional injection of triamcinolone acetonide, 5-fluorouracil, and methotrexate in the treatment of nail psoriasis: A comparative study. ( Abdelmeniem, IM; El Eryan, IM; Fouda, I; Nofal, A; Omar, SS, 2022) |
| "The addition of capecitabine to docetaxel on a 3-week schedule resulted in superior response rate, increased time to progression (TTP), and improved overall survival in patients with anthracycline-pretreated metastatic breast cancer (MBC)." | 9.11 | Final results of a phase II clinical trial of weekly docetaxel in combination with capecitabine in anthracycline-pretreated metastatic breast cancer. ( Au, HJ; Bodnar, DM; Joy, AA; Koski, SL; Mackey, JR; Scarfe, AG; Smith, SW; Smylie, MG; Soulieres, D; Tonkin, KS, 2004) |
| " To compare the efficacy and safety of intralesional injection of 5-fluorouracil (5-FU), methotrexate (MTX), triamcinolone acetonide (TA) versus topical calcipotriol plus urea 20% in the treatment of nail psoriasis." | 5.51 | Topical calcipotriol combined with urea 20% versus intralesional injection of triamcinolone acetonide, 5-fluorouracil, and methotrexate in the treatment of nail psoriasis: A comparative study. ( Abdelmeniem, IM; El Eryan, IM; Fouda, I; Nofal, A; Omar, SS, 2022) |
| "The addition of capecitabine to docetaxel on a 3-week schedule resulted in superior response rate, increased time to progression (TTP), and improved overall survival in patients with anthracycline-pretreated metastatic breast cancer (MBC)." | 5.11 | Final results of a phase II clinical trial of weekly docetaxel in combination with capecitabine in anthracycline-pretreated metastatic breast cancer. ( Au, HJ; Bodnar, DM; Joy, AA; Koski, SL; Mackey, JR; Scarfe, AG; Smith, SW; Smylie, MG; Soulieres, D; Tonkin, KS, 2004) |
| " The lesions appeared during oncology treatment of bilateral breast cancer with lymphatic metastases with paclitaxel every three weeks and capecitabine daily." | 3.73 | [Onycholysis with hyponychium exudate secondary to chemotherapy with paclitaxel and capecitabine]. ( Bosch, RJ; Herrera, E; López, N; Tejera, A, 2006) |
| "Capecitabine is an antineoplastic agent that is currently the only effective treatment for patients with advanced or metastatic breast cancer in whom anthracycline or taxoid treatment has failed." | 3.72 | Onycholysis with the appearance of a "sunset" secondary to capecitabine. ( Maino, KL; Norwood, C; Stashower, ME, 2003) |
| "Psoriasis is a chronic skin disease that affects millions of people throughout the world." | 2.44 | Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy. ( Jiaravuthisan, MM; Muhn, CY; Murphy, F; Sasseville, D; Vender, RB, 2007) |
| "As with treatment of psoriasis affecting skin, relapse is common and therapies may need to be maintained or repeated." | 2.41 | Management of nail psoriasis. ( de Berker, D, 2000) |
| "A 58-year-old woman with linear porokeratosis involving the right hand and arm had distal digital narrowing and nail dystrophy with radiographic changes." | 2.41 | Linear porokeratosis with underlying bony abnormalities. ( Garzon, MC; Grossman, ME; Ilarda, I; Levit, EK; Tseng, SS, 2002) |
| "Alopecia was observed in 60% of patients." | 1.62 | Toxicity profile of taxanes in Tunisian cancer patients: A retrospective study of 90 cases. ( Ayari, J; Balti, M; Ben Abdallah, I; Ben Hassen, M; Ben Nasr, S; Doghri, Y; Fendri, S; Haddaoui, A; Trigui, E; Zribi, A, 2021) |
| " The frequency of grade 3 and 4 adverse effects were comparatively assessed in each treatment arm." | 1.39 | Comparative assessment of skin and subcutaneous toxicity in patients of advanced colorectal carcinoma treated with different schedules of FOLFOX. ( Bano, N; Mateen, A; Najam, R, 2013) |
| "Capecitabine is an oral prodrug of 5-fluorouracil (5-FU), used in the treatment of metastatic colon and breast cancers; it is also under investigation for use in gastric cancers." | 1.35 | Longitudinal melanonychia induced by capecitabine. ( Hymes, SR; Paravar, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.00) | 18.7374 |
| 1990's | 5 (14.29) | 18.2507 |
| 2000's | 14 (40.00) | 29.6817 |
| 2010's | 7 (20.00) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelmeniem, IM | 1 |
| El Eryan, IM | 1 |
| Nofal, A | 1 |
| Fouda, I | 1 |
| Omar, SS | 1 |
| Ben Nasr, S | 1 |
| Zribi, A | 1 |
| Ben Hassen, M | 1 |
| Doghri, Y | 1 |
| Ben Abdallah, I | 1 |
| Trigui, E | 1 |
| Fendri, S | 1 |
| Ayari, J | 1 |
| Balti, M | 1 |
| Haddaoui, A | 1 |
| Chu, NS | 1 |
| Wu, IC | 1 |
| Chen, LT | 1 |
| Chin, YY | 1 |
| Cohen, PR | 1 |
| De Anda, MC | 1 |
| Domínguez, JG | 1 |
| Bano, N | 1 |
| Najam, R | 1 |
| Mateen, A | 1 |
| Morton, CA | 1 |
| Birnie, AJ | 1 |
| Eedy, DJ | 1 |
| Paravar, T | 1 |
| Hymes, SR | 1 |
| Moore, AY | 1 |
| Park, J | 1 |
| Li, K | 1 |
| Vaka, SR | 1 |
| Murthy, SN | 1 |
| O'Haver, JH | 1 |
| Repka, MA | 1 |
| Chen, GY | 2 |
| Chang, TW | 1 |
| Chen, WC | 1 |
| Chen, W | 1 |
| Huang, WT | 1 |
| Muñoz, A | 1 |
| Barceló, R | 1 |
| Rubio, I | 1 |
| Mañé, JM | 1 |
| Ferreiro, J | 1 |
| López-Vivanco, G | 1 |
| GOLDMAN, L | 1 |
| BLANEY, DJ | 1 |
| COHEN, W | 1 |
| Maino, KL | 1 |
| Norwood, C | 1 |
| Stashower, ME | 1 |
| Gül, U | 1 |
| Kiliç, A | 1 |
| Woo, IS | 1 |
| Shim, KH | 1 |
| Kim, GY | 1 |
| Lee, MA | 1 |
| Kang, JH | 1 |
| Hong, YS | 1 |
| Lee, KS | 1 |
| Mackey, JR | 1 |
| Tonkin, KS | 1 |
| Koski, SL | 1 |
| Scarfe, AG | 1 |
| Smylie, MG | 1 |
| Joy, AA | 1 |
| Au, HJ | 1 |
| Bodnar, DM | 1 |
| Soulieres, D | 1 |
| Smith, SW | 1 |
| Tejera, A | 1 |
| Bosch, RJ | 1 |
| López, N | 1 |
| Herrera, E | 1 |
| Jiaravuthisan, MM | 1 |
| Sasseville, D | 1 |
| Vender, RB | 1 |
| Murphy, F | 1 |
| Muhn, CY | 1 |
| Vaccaro, M | 1 |
| Barbuzza, O | 1 |
| Guarneri, F | 1 |
| Guarneri, B | 1 |
| Fredriksson, T | 1 |
| Lane-Brown, MM | 1 |
| Schissel, DJ | 1 |
| Elston, DM | 1 |
| de Berker, D | 1 |
| Tseng, SS | 1 |
| Levit, EK | 1 |
| Ilarda, I | 1 |
| Garzon, MC | 1 |
| Grossman, ME | 1 |
| Katz, ME | 1 |
| Hansen, TW | 1 |
| Abraham, D | 1 |
| Feuerman, EJ | 1 |
| Bianchi, L | 1 |
| Iraci, S | 1 |
| Tomassoli, M | 1 |
| Carrozzo, AM | 1 |
| Nini, G | 1 |
| Gueissaz, F | 1 |
| Borradori, L | 1 |
| Dubertret, L | 1 |
| Tsuji, T | 1 |
| Nishimura, M | 1 |
| Seminara, P | 1 |
| Franchi, F | 1 |
| Codacci-Pisanelli, G | 1 |
| Aronne, T | 1 |
| Abdolrahim zadeh, S | 1 |
| Schmied, E | 1 |
| Levy, PM | 1 |
| Baran, R | 1 |
| Laugier, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Surgical Excision Versus Photodynamic Therapy and Topical 5-fluorouracil in Treatment of Bowen's Disease: a Multicenter Randomized Controlled Trial[NCT03909646] | Phase 4 | 250 participants (Anticipated) | Interventional | 2019-05-27 | Recruiting | ||
| Phase I, Dual Arm, Open-Label, Trial of Intralesional 5-Fluorouracil (5FU) and Intralesional 5FU Combined With Topical Imiquimod in Patients With Squamous Cell Carcinoma (SCC) of the Lower Extremities[NCT03370406] | Phase 1 | 30 participants (Anticipated) | Interventional | 2018-08-03 | Recruiting | ||
| Subclinical Nail Involvement in Relevant Skin Diseases[NCT04092413] | 384 participants (Anticipated) | Observational | 2019-11-01 | Not yet recruiting | |||
| Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic: Nail Disease a Single-blind, Intrapatient Left-to-right Controlled Study.[NCT03263624] | Phase 4 | 30 participants (Anticipated) | Interventional | 2017-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for fluorouracil and Nail Diseases
| Article | Year |
|---|---|
Topical application of 5-fluorouracil 5 percent cream associated with severe neutropenia: discussion of a case and review of systemic reactions after topical treatment with 5-fluorouracil.
Topics: Administration, Cutaneous; Aged; Angioedema; Antimetabolites, Antineoplastic; Cheilitis; Fluorouraci | 2018 |
Clinical applications for topical 5-fluorouracil in the treatment of dermatological disorders.
Topics: Administration, Cutaneous; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Clinical Trials as Topic | 2009 |
Exudative hyponychial dermatitis associated with capecitabine and docetaxel combination chemotherapy for metastatic breast carcinoma: report of three cases.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine | 2003 |
Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy.
Topics: Administration, Topical; Adrenal Cortex Hormones; Anthralin; Clinical Trials as Topic; Cyclosporine; | 2007 |
Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy.
Topics: Administration, Topical; Adrenal Cortex Hormones; Anthralin; Clinical Trials as Topic; Cyclosporine; | 2007 |
Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy.
Topics: Administration, Topical; Adrenal Cortex Hormones; Anthralin; Clinical Trials as Topic; Cyclosporine; | 2007 |
Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of the literature on therapy.
Topics: Administration, Topical; Adrenal Cortex Hormones; Anthralin; Clinical Trials as Topic; Cyclosporine; | 2007 |
Management of nail psoriasis.
Topics: Administration, Topical; Anti-Inflammatory Agents; Antifungal Agents; Cyclosporine; Dermatologic Age | 2000 |
Linear porokeratosis with underlying bony abnormalities.
Topics: Anti-Inflammatory Agents; Bone and Bones; Female; Fluorouracil; Humans; Immunosuppressive Agents; Mi | 2002 |
[Nail psoriasis].
Topics: Administration, Topical; Adrenal Cortex Hormones; Cyclosporine; Fluorouracil; Humans; Nail Diseases; | 1992 |
2 trials available for fluorouracil and Nail Diseases
| Article | Year |
|---|---|
Topical calcipotriol combined with urea 20% versus intralesional injection of triamcinolone acetonide, 5-fluorouracil, and methotrexate in the treatment of nail psoriasis: A comparative study.
Topics: Calcitriol; Dermatologic Agents; Fluorouracil; Humans; Injections, Intralesional; Methotrexate; Nail | 2022 |
Final results of a phase II clinical trial of weekly docetaxel in combination with capecitabine in anthracycline-pretreated metastatic breast cancer.
Topics: Adult; Aged; Anthracyclines; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Ant | 2004 |
26 other studies available for fluorouracil and Nail Diseases
| Article | Year |
|---|---|
Toxicity profile of taxanes in Tunisian cancer patients: A retrospective study of 90 cases.
Topics: Adult; Aged; Alopecia; Antineoplastic Agents; Breast Neoplasms; Cisplatin; Digestive System Diseases | 2021 |
Beau's lines in nails: An indicator of recent Docetaxel and 5-FU use.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Docetax | 2018 |
Melanonychia induced by topical treatment of periungual warts with 5-fluorouracil.
Topics: Administration, Topical; Adult; Antimetabolites; Female; Fluorouracil; Humans; Nail Diseases; Pigmen | 2013 |
Comparative assessment of skin and subcutaneous toxicity in patients of advanced colorectal carcinoma treated with different schedules of FOLFOX.
Topics: Adult; Aged; Aged, 80 and over; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Colorectal | 2013 |
British Association of Dermatologists' guidelines for the management of squamous cell carcinoma in situ (Bowen's disease) 2014.
Topics: Adjuvants, Immunologic; Aminoquinolines; Antimetabolites, Antineoplastic; Bowen's Disease; Cautery; | 2014 |
Longitudinal melanonychia induced by capecitabine.
Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; N | 2009 |
Images in clinical medicine. Multiple Beau's lines.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Fluorouracil; Humans; Ma | 2010 |
A platform for predicting and enhancing model drug delivery across the human nail plate.
Topics: Administration, Topical; Chemistry, Pharmaceutical; Drug Delivery Systems; Female; Fluorouracil; Gel | 2011 |
Single transverse apparent leukonychia caused by 5-fluorouracil plus leucovorin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; | 2003 |
Onycholysis associated with capecitabine in combination with irinotecan in two patients with colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; De | 2003 |
ONYCHODYSTROPHY AFTER TOPICAL 5-FLUOROURACIL.
Topics: Fluorouracil; Humans; Nail Diseases; Nails; Pigmentation Disorders; Skin Neoplasms; Toxicology; Wart | 1963 |
Onycholysis with the appearance of a "sunset" secondary to capecitabine.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Erythema; Fem | 2003 |
Muehrcke's lines on nails after cyclophosphamide/adriamycin/fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Cycloph | 2004 |
Nail changes during docetaxel containing combination chemotherapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemothe | 2004 |
[Onycholysis with hyponychium exudate secondary to chemotherapy with paclitaxel and capecitabine].
Topics: Adult; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; As | 2006 |
Nail and periungual toxicity following capecitabine therapy.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Male; Nail | 2008 |
Psoriatic nails and 5-fluorouracil.
Topics: Administration, Topical; Fluorouracil; Humans; Nail Diseases; Psoriasis | 1982 |
Scalp and nail psoriasis.
Topics: Dermatologic Agents; Fluorouracil; Humans; Nail Diseases; Psoriasis; Scalp Dermatoses | 1980 |
Topical 5-fluorouracil treatment for psoriatic trachyonychia.
Topics: Administration, Topical; Female; Fluorouracil; Humans; Middle Aged; Nail Diseases; Psoriasis | 1998 |
Nail plate-nail bed separation. An unusual side effect of systemic fluorouracil administration.
Topics: Adult; Female; Fluorouracil; Humans; Nail Diseases | 1979 |
[Local treatment of psoriatic nails with 5-fluorouracil].
Topics: Administration, Topical; Fluorouracil; Humans; Nail Diseases; Psoriasis | 1978 |
Coexistence of apparent transverse leukonychia (Muehrcke's lines type) and longitudinal melanonychia after 5-fluorouracil/adriamycin/cyclophosphamide chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; | 1992 |
Topically administered fluorouracil in acrodermatitis continua of Hallopeau.
Topics: Acrodermatitis; Administration, Topical; Adult; Fluorouracil; Humans; Male; Nail Diseases; Ointments | 1991 |
Discoloration of the nails and early anemia after mitoxantrone, folinic acid and 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Folic Acid; Hemoglobins; Human | 1990 |
Transient rhabdomyolysis connected with topical use of 5-fluorouracil in a patient with psoriasis of the nails.
Topics: Administration, Topical; Adult; Fluorouracil; Humans; Male; Nail Diseases; Psoriasis; Rhabdomyolysis | 1986 |
Melanonychia induced by topical 5-fluorouracil.
Topics: Aged; Female; Fluorouracil; Humans; Nail Diseases; Nails; Pigmentation Disorders | 1985 |