Page last updated: 2024-10-27

fluorouracil and Myocardial Infarction

fluorouracil has been researched along with Myocardial Infarction in 49 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

Research Excerpts

ExcerptRelevanceReference
"5-Fluorouracil, a widely used drug in cancer treatment, is known to have cardiotoxic effects: chest pain with ECG changes, arrhythmias, arterial hypertension or hypotension, myocardial infarction, cardiogenic shock and sudden death have been described in the literature."7.72Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases. ( Alberti, A; Corrada, E; Ferrari, S; Mafrici, A; Marenna, B, 2003)
"A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed."7.715-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report. ( Campbell, NP; McGlinchey, PG; Webb, ST, 2001)
"A 53-year-old female patient was treated with combined radiochemotherapy with 5-fluorouracil (5-FU) because of adenocarcinoma of the lung."7.69[5-fluorouracil: cause of a fatal myocardial infarction in combined radiochemotherapy?]. ( Härle, M; Jungius, KP; Maurer, U, 1996)
"Three cases of cardiotoxicity manifested by chest pain, tachycardia, respiratory distress, and electrocardiographic changes simulating acute myocardial infarction or ischemia were observed during the course of combination chemotherapy with etoposide, cisplatin, and continuous infusion of 5-fluorouracil in patients with advanced non-small cell lung cancer."7.68Electrocardiographic changes simulating acute myocardial infarction or ischemia associated with combination chemotherapy with etoposide, cisplatin, and 5-fluorouracil. ( Kim, SH; Lee, JS; Lee, KH, 1990)
"Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion."5.38Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible. ( Celiker, E; Eren, M; Güvenç, TS; Ilhan, E; Ozcan, KS, 2012)
"Capecitabine is a chemotherapeutic prodrug that is metabolised to 5-fluorouracil."5.35Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction. ( Curzen, NP; Ferchow, L; Hobson, A; Scott, PA, 2008)
"To investigate cardiac toxicity associated with breast radiation therapy (RT) at 10-year follow-up in BCIRG-001, a phase 3 trial comparing adjuvant anthracycline chemotherapy (fluorouracil, doxorubicin, and cyclophosphamide) with anthracycline-taxane chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) in women with lymph node-positive early breast cancer."5.24Effect of Breast Irradiation on Cardiac Disease in Women Enrolled in BCIRG-001 at 10-Year Follow-Up. ( Gerber, NK; Perez, CA; Tam, M; Vega, RM; Wu, SP, 2017)
"Two cases of 5-Fluorouracil (5FU) cardiotoxicity, chest pain with changes in ECG the former, and myocardial infarction the latter, are described."4.77[Cardiotoxicity of 5-fluorouracil. Personal cases and review of the literature]. ( Beretta, GD; Borsotti, E; Calasso, F; Carini, L; De Ceglia, S; Labianca, R; Rocca, A; Segalini, G, 1987)
"Two cases of 5-fluorouracil cardiotoxicity, resulting in one patient in myocardial infarction, are described."4.765-Fuorouracil cardiotoxicity. ( Guindani, A; Pagnoni, A; Villani, F, 1979)
" Two of the patients could not be treated with 5-FU any more because they had developed a myocardial ischemia, which was most likely caused by fluorouracil."3.785-FU-induced cardiac toxicity--an underestimated problem in radiooncology? ( Hautmann, MG; Kölbl, O; Steger, F, 2012)
"5-Fluorouracil, a widely used drug in cancer treatment, is known to have cardiotoxic effects: chest pain with ECG changes, arrhythmias, arterial hypertension or hypotension, myocardial infarction, cardiogenic shock and sudden death have been described in the literature."3.72Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases. ( Alberti, A; Corrada, E; Ferrari, S; Mafrici, A; Marenna, B, 2003)
"A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed."3.715-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report. ( Campbell, NP; McGlinchey, PG; Webb, ST, 2001)
"A 53-year-old female patient was treated with combined radiochemotherapy with 5-fluorouracil (5-FU) because of adenocarcinoma of the lung."3.69[5-fluorouracil: cause of a fatal myocardial infarction in combined radiochemotherapy?]. ( Härle, M; Jungius, KP; Maurer, U, 1996)
" Nine patients had symptoms resembling myocardial ischemia, one patient died due to assumed myocardial infarction related closely to fluorouracil treatment, four patients had supraventricular arrhythmia, and one patient had congestive heart failure."3.68Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer. ( Bokemeyer, C; Harstrick, A; Hiddemann, W; Köhne-Wömpner, CH; Mügge, A; Papageorgiou, E; Poliwoda, H; Schöber, C; Stahl, M; Wilke, H, 1993)
"Three cases of cardiotoxicity manifested by chest pain, tachycardia, respiratory distress, and electrocardiographic changes simulating acute myocardial infarction or ischemia were observed during the course of combination chemotherapy with etoposide, cisplatin, and continuous infusion of 5-fluorouracil in patients with advanced non-small cell lung cancer."3.68Electrocardiographic changes simulating acute myocardial infarction or ischemia associated with combination chemotherapy with etoposide, cisplatin, and 5-fluorouracil. ( Kim, SH; Lee, JS; Lee, KH, 1990)
"Acute myocardial infarction was observed in two patients receiving standard intravenous doses of 5-fluorouracil (5-FU)-based chemotherapy."3.68Thrombogenicity of intravenous 5-fluorouracil alone or in combination with cisplatin. ( Esparaz, B; Green, D; Kies, M; Kuzel, T, 1990)
"The authors describe the first case of myocardial infarction in their department which occurred during 5-fluorouracil treatment."3.67[The development of myocardial infarct in a patient treated with 5-fluorouracil]. ( Bulas, J; Cerná, M; Danko, J; Kasper, J; Murín, J; Uhliar, R, 1989)
"We report a case of advanced rectal cancer with bladder carcinoma."1.39[A case of advanced rectal cancer with bladder carcinoma salvaged from myocardial infarction during operation, showing tumor regression by XELOX treatment, good quality of life]. ( Kodama, M; Mekata, E; Okumura, K; Shiogai, Y; Tani, S; Tani, T, 2013)
"Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion."1.38Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible. ( Celiker, E; Eren, M; Güvenç, TS; Ilhan, E; Ozcan, KS, 2012)
"Capecitabine is a chemotherapeutic prodrug that is metabolised to 5-fluorouracil."1.35Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction. ( Curzen, NP; Ferchow, L; Hobson, A; Scott, PA, 2008)
" Five cardiopulmonary toxic events of Grade 3 or greater were observed in 4 patients, Grade 5 heart failure and Grade 3 pericarditis in 1 patient, and Grade 3 myocardial infarction, Grade 3 radiation pneumonitis, and Grade 3 pleural effusion."1.35Late toxicity after definitive concurrent chemoradiotherapy for thoracic esophageal carcinoma. ( Chin, K; Gomi, K; Ito, H; Kozuka, T; Matsuura, M; Morota, M; Oguchi, M; Yamashita, T, 2009)
" Coronary spasm is the most commonly suspected hypothesis, but further studies are warranted to seek for toxic inflammatory lesions of the myocardium (apoptosis, necrosis, fibrosis)."1.33Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease. ( Barel, C; Belkhiria, M; Bui-Xuan, B; Descotes, J; Lombard-Bohas, C; Tabib, A; Timour, Q; Tsibiribi, P, 2006)
"5-Fluorouracil (5-FU) is a chemotherapeutic agent which has been used to treat many solid tumors including cancers of the breast, ovary, cervix, bladder, prostate gland and gastrointestinal tract."1.29Cardiotoxicity related to 5-fluorouracil chemotherapy: a report of two cases. ( Chao, TY; Wang, WB; Weng, MC, 1995)
"5-Fluorouracil is widely known to be toxic to the hematopoietic and gastrointestinal systems."1.29Clinical cardiotoxicity of 5-fluorouracil. ( Keefe, DL; Pierri, MK; Roistacher, N, 1993)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19909 (18.37)18.7374
1990's18 (36.73)18.2507
2000's12 (24.49)29.6817
2010's10 (20.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wu, SP1
Tam, M1
Vega, RM1
Perez, CA1
Gerber, NK1
Zhang, D1
Ma, J1
Rateesh, S1
Luis, SA1
Luis, CR1
Hughes, B1
Nicolae, M1
Scott, PA1
Ferchow, L1
Hobson, A1
Curzen, NP1
Morota, M1
Gomi, K1
Kozuka, T1
Chin, K1
Matsuura, M1
Oguchi, M1
Ito, H1
Yamashita, T1
Karabay, CY1
Gecmen, C1
Aung, SM1
Guler, A1
Candan, O1
Batgerel, U1
Kalayci, A1
Kirma, C1
Killu, A1
Madhavan, M1
Prasad, K1
Prasad, A1
Güvenç, TS1
Celiker, E1
Ozcan, KS1
Ilhan, E1
Eren, M1
Okines, AF1
Langley, RE1
Thompson, LC1
Stenning, SP1
Stevenson, L1
Falk, S1
Seymour, M1
Coxon, F1
Middleton, GW1
Smith, D1
Evans, L1
Slater, S1
Waters, J1
Ford, D1
Hall, M1
Iveson, TJ1
Petty, RD1
Plummer, C1
Allum, WH1
Blazeby, JM1
Griffin, M1
Cunningham, D1
Steger, F1
Hautmann, MG1
Kölbl, O1
Ozturk, MA1
Ozveren, O1
Cinar, V1
Erdik, B1
Oyan, B1
Okumura, K1
Tani, S1
Shiogai, Y1
Kodama, M1
Mekata, E1
Tani, T1
Erol, MK1
Acikel, M1
Senocak, H1
Mafrici, A1
Alberti, A1
Corrada, E1
Ferrari, S1
Marenna, B1
Leitman, M1
Baram, S1
Sidenko, S1
Abo-Kishk, I1
Peleg, E1
Vered, Z1
Gul, M1
Duzenli, A1
Bircan, M1
Cander, B1
Kocak, S1
Ozdemir, K1
Tsibiribi, P1
Descotes, J1
Lombard-Bohas, C1
Barel, C1
Bui-Xuan, B1
Belkhiria, M1
Tabib, A1
Timour, Q1
Lu, JI1
Carhart, RL1
Graziano, SL1
Gajra, A1
Gundling, F1
Fuchs, M1
Nowak, L1
Antoni, D1
Hoffmann, E1
Schepp, W1
Canale, ML1
Camerini, A1
Stroppa, S1
Porta, RP1
Caravelli, P1
Mariani, M1
Balbarini, A1
Ricci, S1
Misao, Y1
Arai, M1
Ohno, T1
Ushikoshi, H1
Onogi, H1
Kobayashi, H1
Takemura, G1
Minatoguchi, S1
Fujiwara, T1
Fujiwara, H1
Sacks, H1
Chalmers, TC1
Smith, H1
Labianca, R3
Beretta, G1
Clerici, M1
Fraschini, P1
Luporini, G2
Mizuno, Y1
Hokamura, Y1
Kimura, T1
Kimura, Y1
Kaikita, K1
Yasue, H1
Weng, MC1
Wang, WB1
Chao, TY1
Jameson, M1
Thompson, P1
Hastie, B1
Unverdorben, M1
Birkenhake, S1
Kunkel, B1
Dunst, J1
Keefe, DL1
Roistacher, N1
Pierri, MK1
Schöber, C1
Papageorgiou, E1
Harstrick, A1
Bokemeyer, C1
Mügge, A1
Stahl, M1
Wilke, H1
Poliwoda, H1
Hiddemann, W1
Köhne-Wömpner, CH1
Anderson, NR1
Lokich, JJ1
Moore, C1
Maurer, U1
Härle, M1
Jungius, KP1
Farooqi, IS1
Aronson, JK1
Pedersen, K1
Mixon, R1
Donovan, CT1
McGlinchey, PG1
Webb, ST1
Campbell, NP1
Villani, F1
Guindani, A1
Pagnoni, A1
Tomomatsu, H1
Morita, N1
Nagai, T1
Shiwaku, Y1
Shingami, T1
Miura, Y1
Kihara, K1
Nakao, Y1
Shimokawahara, H1
Hashimoto, S1
Yunoki, K1
Andrieu, J1
Crenn, P1
Schwob, J1
Roussin-Bretagne, S1
Jean, F1
Zeymer, U1
Neuhaus, KL1
Fonte, CE1
Cardello, F1
Braumann, D1
Mainzer, K1
Günzl, C1
Lewerenz, B1
Lee, KH1
Lee, JS1
Kim, SH1
Höring, E1
Neef, B1
von Gaisberg, U1
Kuzel, T1
Esparaz, B1
Green, D1
Kies, M1
Cierlińska, M1
Kostecka-Pokryszko, A1
Kuźnicki, J1
Czajkowska, R1
Murín, J1
Kasper, J1
Danko, J1
Cerná, M1
Bulas, J1
Uhliar, R1
Ensley, JF1
Patel, B1
Kloner, R1
Kish, JA1
Wynne, J1
al-Sarraf, M1
Segalini, G1
Beretta, GD1
Borsotti, E1
Calasso, F1
Carini, L1
De Ceglia, S1
Rocca, A1
Leone, B1
Rabinovich, M1
Ferrari, CR1
Boyer, J1
Rosso, H1
Strauss, E1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Individual Radiosensitivity of Cancer Patients to be Treated by Radiotherapy or Radiochemotherapy Per-operative[NCT02797405]97 participants (Actual)Interventional2016-10-31Terminated (stopped due to Withdrawal of analysis study Partner.)
A Randomised Phase II/III Trial of Peri-Operative Chemotherapy With or Without Bevacizumab in Operable Oesophagogastric Adenocarcinoma and A Feasibility Study Evaluating Lapatinib in HER-2 Positive Oesophagogastric Adenocarcinomas and (in Selected Centres[NCT00450203]Phase 2/Phase 31,103 participants (Anticipated)Interventional2007-10-31Recruiting
Apatinib Plus XELOX Regime as Neoadjuvant Therapy in Locally Advanced Gastric Cancer Patients With Lymph Node Metastasis[NCT03229096]Phase 235 participants (Anticipated)Interventional2017-02-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for fluorouracil and Myocardial Infarction

ArticleYear
Takotsubo syndrome: an underdiagnosed complication of 5-fluorouracil mimicking acute myocardial infarction.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2013, Volume: 24, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth

2013
5-Fuorouracil cardiotoxicity.
    Tumori, 1979, Aug-31, Volume: 65, Issue:4

    Topics: Adult; Aged; Angina Pectoris; Electrocardiography; Female; Fluorouracil; Heart; Humans; Male; Middle

1979
[Cardiotoxicity of 5-fluorouracil. Personal cases and review of the literature].
    Giornale italiano di cardiologia, 1987, Volume: 17, Issue:9

    Topics: Aged; Angina Pectoris; Female; Fluorouracil; Heart; Humans; Male; Myocardial Infarction

1987

Trials

2 trials available for fluorouracil and Myocardial Infarction

ArticleYear
Effect of Breast Irradiation on Cardiac Disease in Women Enrolled in BCIRG-001 at 10-Year Follow-Up.
    International journal of radiation oncology, biology, physics, 2017, 11-01, Volume: 99, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Card

2017
Bevacizumab with peri-operative epirubicin, cisplatin and capecitabine (ECX) in localised gastro-oesophageal adenocarcinoma: a safety report.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:3

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protoc

2013
Bevacizumab with peri-operative epirubicin, cisplatin and capecitabine (ECX) in localised gastro-oesophageal adenocarcinoma: a safety report.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:3

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protoc

2013
Bevacizumab with peri-operative epirubicin, cisplatin and capecitabine (ECX) in localised gastro-oesophageal adenocarcinoma: a safety report.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:3

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protoc

2013
Bevacizumab with peri-operative epirubicin, cisplatin and capecitabine (ECX) in localised gastro-oesophageal adenocarcinoma: a safety report.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:3

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protoc

2013

Other Studies

44 other studies available for fluorouracil and Myocardial Infarction

ArticleYear
Mitochondrial Dynamics in Rat Heart Induced by 5-Fluorouracil.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Sep-21, Volume: 24

    Topics: Animals; Fluorouracil; Heart; Male; Membrane Potential, Mitochondrial; Mitochondria; Mitochondria, H

2018
Myocardial infarction secondary to 5-fluorouracil: not an absolute contraindication to rechallenge?
    International journal of cardiology, 2014, Mar-15, Volume: 172, Issue:2

    Topics: Adult; Antineoplastic Agents; Drug Administration Schedule; Fluorouracil; Humans; Male; Myocardial I

2014
Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction.
    Emergency medicine journal : EMJ, 2008, Volume: 25, Issue:10

    Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Chest Pain; Colorectal Neoplasms; Coronary Vaso

2008
Late toxicity after definitive concurrent chemoradiotherapy for thoracic esophageal carcinoma.
    International journal of radiation oncology, biology, physics, 2009, Sep-01, Volume: 75, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squ

2009
Is 5-fluorouracil-induced vasospasm a Kounis syndrome? A diagnostic challenge.
    Perfusion, 2011, Volume: 26, Issue:6

    Topics: Antimetabolites, Antineoplastic; Carcinoma, Signet Ring Cell; Coronary Vasospasm; Electrocardiograph

2011
5-fluorouracil induced pericarditis.
    BMJ case reports, 2011, Apr-15, Volume: 2011

    Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Diagnosis, Differential; Fluorouracil; Humans; M

2011
Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible.
    Chinese medical journal, 2012, Volume: 125, Issue:18

    Topics: Capecitabine; Coronary Thrombosis; Coronary Vasospasm; Deoxycytidine; Female; Fluorouracil; Humans;

2012
5-FU-induced cardiac toxicity--an underestimated problem in radiooncology?
    Radiation oncology (London, England), 2012, Dec-15, Volume: 7

    Topics: Aged; Antimetabolites, Antineoplastic; Carcinoma; Cardiotoxins; Chemoradiotherapy; Electrocardiograp

2012
[A case of advanced rectal cancer with bladder carcinoma salvaged from myocardial infarction during operation, showing tumor regression by XELOX treatment, good quality of life].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:1

    Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluo

2013
Non-Q-Wave acute anterior myocardial infarction associated with 5-fluorouracil and cisplatin chemotherapy.
    Southern medical journal, 2003, Volume: 96, Issue:1

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; F

2003
Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases.
    Italian heart journal : official journal of the Italian Federation of Cardiology, 2003, Volume: 4, Issue:12

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antimetabolites, Antineoplas

2003
Transient left ventricular and right atrial thrombosis after 5-fluorouracil therapy.
    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2004, Volume: 17, Issue:7

    Topics: Abdominal Neoplasms; Adolescent; Carcinoma, Signet Ring Cell; Echocardiography; Fluorouracil; Heart

2004
Cardiotoxicity resembling myocardial infarction that occurs during chemotherapy with 5-fluorouracil.
    Saudi medical journal, 2005, Volume: 26, Issue:11

    Topics: Adenocarcinoma; Adult; Chest Pain; Colonic Neoplasms; Diagnosis, Differential; Electrocardiography;

2005
Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease.
    Bulletin du cancer, 2006, Mar-01, Volume: 93, Issue:3

    Topics: Adult; Aged; Angina Pectoris; Antimetabolites, Antineoplastic; Cardiac Output, Low; Chest Pain; Fema

2006
Acute coronary syndrome secondary to fluorouracil infusion.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jun-20, Volume: 24, Issue:18

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplas

2006
["Iatrogenic acute coronary syndrome"--59 year old patient with adenocarcinoma of ascending colon and stenocardia while receiving adjuvant chemotherapy with 5-fluorouracil].
    Zeitschrift fur Gastroenterologie, 2006, Volume: 44, Issue:9

    Topics: Adenocarcinoma; Angina Pectoris; Chemotherapy, Adjuvant; Colon, Ascending; Colonic Neoplasms; Fluoro

2006
A case of acute myocardial infarction during 5-fluorouracil infusion.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2006, Volume: 7, Issue:11

    Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Coronary Angiography; Creatine Kinase, MB For

2006
Modification of post-myocardial infarction granulocyte-colony stimulating factor therapy with myelo-suppressives.
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:4

    Topics: Animals; Apoptosis; Benzylamines; Blood Cell Count; Chemokine CXCL12; Chemokines, CXC; Cyclams; Cycl

2007
Randomized versus historical controls for clinical trials.
    The American journal of medicine, 1982, Volume: 72, Issue:2

    Topics: Abortion, Habitual; Anticoagulants; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Corona

1982
Cardiac toxicity of 5-fluorouracil: a study on 1083 patients.
    Tumori, 1982, Dec-31, Volume: 68, Issue:6

    Topics: Aged; Angina Pectoris; Drug Therapy, Combination; Female; Fluorouracil; Heart; Humans; Male; Middle

1982
A case of 5-fluorouracil cardiotoxicity simulating acute myocardial infarction.
    Japanese circulation journal, 1995, Volume: 59, Issue:5

    Topics: Aged; Breast Neoplasms; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diagnosis, Differentia

1995
Cardiotoxicity related to 5-fluorouracil chemotherapy: a report of two cases.
    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 1995, Volume: 55, Issue:3

    Topics: Aged; Female; Fluorouracil; Humans; Male; Middle Aged; Myocardial Infarction; Nasopharyngeal Neoplas

1995
5 Fluorouracil cardiotoxicity.
    The New Zealand medical journal, 1995, Jan-25, Volume: 108, Issue:992

    Topics: Adult; Fluorouracil; Heart; Humans; Male; Myocardial Infarction

1995
[Extended reversible global left ventricular contraction dysfunction with symptomless coronary system as effect of cytostatic therapy with 5-fluorouracil].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1994, Volume: 170, Issue:8

    Topics: Anus Neoplasms; Combined Modality Therapy; Coronary Angiography; Coronary Vasospasm; Diagnosis, Diff

1994
Clinical cardiotoxicity of 5-fluorouracil.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:11

    Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Female; Fluorouracil; Heart Arr

1993
Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer.
    Cancer, 1993, Oct-01, Volume: 72, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Coronary Disease;

1993
The syndrome of 5-fluorouracil cardiotoxicity: an elusive cardiopathy.
    Cancer, 1993, Oct-01, Volume: 72, Issue:7

    Topics: Angina Pectoris; Fluorouracil; Heart Diseases; Humans; Myocardial Infarction

1993
[5-fluorouracil: cause of a fatal myocardial infarction in combined radiochemotherapy?].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1996, Volume: 172, Issue:5

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Antimetabolites, Antineoplastic; Fatal Outcome; Female; Flu

1996
Iatrogenic chest pain: a case of 5-fluorouracil cardiotoxicity.
    QJM : monthly journal of the Association of Physicians, 1996, Volume: 89, Issue:12

    Topics: Acute Disease; Aged; Antimetabolites, Antineoplastic; Chest Pain; Fluorouracil; Humans; Male; Myocar

1996
Nurses develop a care standard for 5-fluorouracil-associated cardiotoxicity.
    Oncology nursing forum, 1997, Volume: 24, Issue:8

    Topics: Aged; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Male; Myocardial Infarction; Oncology N

1997
5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report.
    BMC cardiovascular disorders, 2001, Volume: 1

    Topics: Aged; Antimetabolites, Antineoplastic; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diagnos

2001
[A case with gastric cancer by OK-MF'C therapy (author's transl)].
    Igaku kenkyu. Acta medica, 1979, Volume: 49, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Cytarabine; Drug Therapy, Combination; Fluorouracil; Humans;

1979
[Myocardial damage after use of 5 fluorouracil in digestive pathology].
    Gastroenterologie clinique et biologique, 1991, Volume: 15, Issue:10

    Topics: Aged; Fluorouracil; Humans; Male; Myocardial Infarction; Rectal Neoplasms

1991
5-fluorouracil cardiotoxicity: the risk of rechallenge.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2, Issue:5

    Topics: Angina Pectoris; Coronary Vasospasm; Fluorouracil; Humans; Myocardial Infarction; Recurrence

1991
[The cardiotoxic side effects of 5-fluorouracil].
    Deutsche medizinische Wochenschrift (1946), 1991, Feb-01, Volume: 116, Issue:5

    Topics: Angina Pectoris; Electrocardiography; Fluorouracil; Heart; Humans; Male; Middle Aged; Myocardial Inf

1991
Chest pain in a cancer patient on chemotherapy.
    Hospital practice (Office ed.), 1991, Jul-15, Volume: 26, Issue:7

    Topics: Adenocarcinoma; Adult; Colonic Neoplasms; Fluorouracil; Humans; Male; Myocardial Infarction; Strepto

1991
[Myocardial infarcts within the scope of 5-fluorouracil therapy].
    Onkologie, 1990, Volume: 13, Issue:6

    Topics: Adenocarcinoma; Adult; Electrocardiography; Fluorouracil; Humans; Infusions, Intravenous; Liver Neop

1990
Electrocardiographic changes simulating acute myocardial infarction or ischemia associated with combination chemotherapy with etoposide, cisplatin, and 5-fluorouracil.
    The Korean journal of internal medicine, 1990, Volume: 5, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Coronary Disease; Diagnosis,

1990
Intramural myocardial infarction under combined radiochemotherapy of an oesophageal carcinoma.
    Journal of cancer research and clinical oncology, 1990, Volume: 116, Issue:6

    Topics: Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Esophageal Neoplasms; Fluorouracil;

1990
Thrombogenicity of intravenous 5-fluorouracil alone or in combination with cisplatin.
    Cancer, 1990, Feb-15, Volume: 65, Issue:4

    Topics: Adult; Aged; Anus Neoplasms; Carcinoma, Squamous Cell; Cisplatin; Fibrinogen; Fibrinopeptide A; Fluo

1990
[Threatened myocardial infarction during the treatment with 5-fluorouracil].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1987, Aug-01, Volume: 40, Issue:15

    Topics: Cecal Neoplasms; Fluorouracil; Humans; Male; Middle Aged; Myocardial Infarction; Palliative Care

1987
[The development of myocardial infarct in a patient treated with 5-fluorouracil].
    Vnitrni lekarstvi, 1989, Volume: 35, Issue:10

    Topics: Adult; Electrocardiography; Fluorouracil; Humans; Lip Neoplasms; Male; Myocardial Infarction

1989
The clinical syndrome of 5-fluorouracil cardiotoxicity.
    Investigational new drugs, 1989, Volume: 7, Issue:1

    Topics: Adult; Aged; Coronary Disease; Death, Sudden; Electrocardiography; Female; Fluorouracil; Heart Disea

1989
Cardiotoxicity as a result of 5-fluorouracil therapy.
    Tumori, 1985, Feb-28, Volume: 71, Issue:1

    Topics: Adenocarcinoma; Adult; Fluorouracil; Heart; Humans; Male; Myocardial Infarction; Sigmoid Neoplasms;

1985