fluorouracil has been researched along with Muscle Tissue Neoplasms in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Poortmans, PM | 1 |
| Richaud, P | 1 |
| Collette, L | 1 |
| Ho Goey, S | 1 |
| Pierart, M | 1 |
| Van Der Hulst, M | 1 |
| Bolla, M | 1 |
| Michelet, FX | 1 |
| Benoit, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Feasibility Study of Combined Accelerated External Radiation and Chemotherapy With 5FU and CDDP Following Transurethral Resection in Patients With Muscle Invasive Transitional Carcinoma of the Bladder - T2-T3, N0, M0 (UICC 1992)[NCT00003642] | Phase 2 | 43 participants (Anticipated) | Interventional | 1998-10-31 | Terminated (stopped due to low accrual) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for fluorouracil and Muscle Tissue Neoplasms
| Article | Year |
|---|---|
Results of the phase II EORTC 22971 trial evaluating combined accelerated external radiation and chemotherapy with 5FU and cisplatin in patients with muscle invasive transitional cell carcinoma of the bladder.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Chemotherapy, Ad | 2008 |
1 other study available for fluorouracil and Muscle Tissue Neoplasms
| Article | Year |
|---|---|
[Combination of chemotherapy and electrocoagulation in the treatment of gingival cancers].
Topics: Electrocoagulation; Fluorouracil; Gingival Diseases; Humans; Methotrexate; Mouth Neoplasms; Neoplasm | 1968 |