fluorouracil has been researched along with Multiple Endocrine Neoplasia Type 1 in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Multiple Endocrine Neoplasia Type 1: A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mayer, P | 1 |
| Harjung, A | 1 |
| Breinig, M | 1 |
| Fischer, L | 1 |
| Ehemann, V | 1 |
| Malz, M | 1 |
| Scherübl, H | 1 |
| Britsch, S | 1 |
| Werner, J | 1 |
| Kern, MA | 1 |
| Bläker, H | 1 |
| Schirmacher, P | 1 |
| Bergmann, F | 1 |
| Gulati, AP | 1 |
| Krantz, B | 1 |
| Moss, RA | 1 |
| Moyal, WN | 1 |
| Tsushima, DA | 1 |
| Mowatt, KB | 1 |
| Schreibman, S | 1 |
| Fine, RL | 1 |
| Botsios, D | 1 |
| Vasiliadis, K | 1 |
| Tsalis, K | 1 |
| Iordanidis, F | 1 |
| Megalopoulos, A | 1 |
| Tsachalis, T | 1 |
| Blouhos, K | 1 |
| Betsis, D | 1 |
1 review available for fluorouracil and Multiple Endocrine Neoplasia Type 1
| Article | Year |
|---|---|
Treatment of multiple endocrine neoplasia 1/2 tumors: case report and review of the literature.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Dacarbazine; Deoxycytidine; Fluorourac | 2013 |
2 other studies available for fluorouracil and Multiple Endocrine Neoplasia Type 1
| Article | Year |
|---|---|
Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antibiotics, Antineoplastic; Antimetabolites, A | 2012 |
Management of nonfunctioning pancreatic endocrine tumors in the context of multiple endocrine neoplasia type 1 syndrome.
Topics: Adolescent; Adult; Chemotherapy, Adjuvant; Drug Therapy, Combination; Endosonography; Female; Fluoro | 2007 |