fluorouracil has been researched along with Mouth Diseases in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Mouth Diseases: Diseases involving the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-five consecutive breast cancer patients, eligible for adjuvant CT with cyclophosphamide, epirubicin or methotrexate, and 5-fluorouracil were followed before, during, 6 months and 1 year after CT and were compared to a control group of 31 breast cancer patients not receiving adjuvant CT." | 3.74 | Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. ( Bergmann, OJ; Brünner, N; Jensen, SB; Mouridsen, HT; Nauntofte, B; Reibel, J, 2008) |
| "The effects of cisplatin and 5-fluorouracil on wound breaking strength and the rate of closure of an orocutaneous fistula were studied in 80 male rodents." | 3.68 | The effects of chemotherapy on murine wound healing and orocutaneous fistula closure. ( al-Sarraf, M; Grabow, D; Guan, ZX; Ledgerwood, AM; Lucas, CE; Weaver, A; Whittle, T, 1990) |
| "Among patients with primary head and neck cancer, the stage of the disease influenced the response rate." | 2.65 | Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer. ( Archibald, SD; Browman, GP; Hryniuk, WM; Kiehl, K; Levine, MN; Russell, R; Young, JE, 1983) |
| "Ulcerative oral mucositis can be costly to healthcare systems, yet there are few preventive interventions proven to be beneficial." | 2.52 | Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. ( Clarkson, JE; Glenny, AM; Littlewood, A; McCabe, MG; Riley, P; Worthington, HV, 2015) |
| "Weight gain was noted in the treatment groups compared with the gel base and control groups (P < ." | 1.39 | Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis. ( Amanat, D; Garcia-Godoy, F; Saghiri, MA; Samani, SM; Tadbir, AA; Tamadon, A; Tanideh, N; Tavakoli, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Sethi, A | 1 |
| Ahmad, M | 1 |
| Huma, T | 1 |
| Ahmad, W | 1 |
| Co, ML | 1 |
| Esteban, MJ | 1 |
| Riley, P | 1 |
| Glenny, AM | 1 |
| Worthington, HV | 1 |
| Littlewood, A | 1 |
| Clarkson, JE | 1 |
| McCabe, MG | 1 |
| Jensen, SB | 1 |
| Mouridsen, HT | 1 |
| Bergmann, OJ | 1 |
| Reibel, J | 1 |
| Brünner, N | 1 |
| Nauntofte, B | 1 |
| Tanideh, N | 1 |
| Tavakoli, P | 1 |
| Saghiri, MA | 1 |
| Garcia-Godoy, F | 1 |
| Amanat, D | 1 |
| Tadbir, AA | 1 |
| Samani, SM | 1 |
| Tamadon, A | 1 |
| MURRAY, EG | 1 |
| Browman, GP | 1 |
| Archibald, SD | 1 |
| Young, JE | 1 |
| Hryniuk, WM | 1 |
| Russell, R | 1 |
| Kiehl, K | 1 |
| Levine, MN | 1 |
| Emerson, SS | 1 |
| Whittle, T | 1 |
| Lucas, CE | 1 |
| Ledgerwood, AM | 1 |
| Weaver, A | 1 |
| al-Sarraf, M | 1 |
| Guan, ZX | 1 |
| Grabow, D | 1 |
| Perry, DJ | 1 |
| Davis, RK | 1 |
| Duttenhaver, JR | 1 |
| Zajtchuk, JT | 1 |
| Hauck, KH | 1 |
| Major, WB | 1 |
| Baumann, JC | 1 |
| Guillaume, JC | 1 |
| Carp, E | 1 |
| Rougier, P | 1 |
| Charpentier, P | 1 |
| André, P | 1 |
| Carde, P | 1 |
| Avril, MF | 1 |
1 review available for fluorouracil and Mouth Diseases
| Article | Year |
|---|---|
Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy.
Topics: Adult; Antineoplastic Agents; Cryotherapy; Fluorouracil; Hematopoietic Stem Cell Transplantation; Hu | 2015 |
1 trial available for fluorouracil and Mouth Diseases
| Article | Year |
|---|---|
Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Clinical Tria | 1983 |
9 other studies available for fluorouracil and Mouth Diseases
| Article | Year |
|---|---|
Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity.
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparations; Dr | 2021 |
Lingual hyperpigmentation after 5-fluorouracil chemotherapy.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Female; Fluor | 2017 |
Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Al | 2008 |
Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis.
Topics: Abscess; Animals; Antimetabolites, Antineoplastic; Calendula; Carboxymethylcellulose Sodium; Criceti | 2013 |
A discussion of fuso-spirochaetal disease of the mouth.
Topics: Face; Fluorouracil; Humans; Mouth Diseases | 1949 |
Stopping a clinical trial very early based on unplanned interim analyses: a group sequential approach.
Topics: Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biometry | 1995 |
The effects of chemotherapy on murine wound healing and orocutaneous fistula closure.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Fistula; Fluorouracil; Male; Mou | 1990 |
Multimodality therapy for unresectable squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Ci | 1985 |
[Cutaneomucous adverse effects of continuous infusion of 5-fluorouracil: 12 cases].
Topics: Adult; Drug Eruptions; Female; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Infusions, In | 1988 |