fluorouracil has been researched along with Mitochondrial Diseases in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Radiation bystander effects induce genomic instability; however, the mechanism driving this instability is unknown." | 1.35 | Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction. ( Gorman, S; Howe, O; Hyland, J; Lyng, F; Mulcahy, H; O'Donoghue, D; O'Sullivan, J; Sheahan, K; Tosetto, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Takei, S | 1 |
| Homma, Y | 1 |
| Matsuyama, R | 1 |
| Endo, I | 1 |
| Gorman, S | 1 |
| Tosetto, M | 1 |
| Lyng, F | 1 |
| Howe, O | 1 |
| Sheahan, K | 1 |
| O'Donoghue, D | 1 |
| Hyland, J | 1 |
| Mulcahy, H | 1 |
| O'Sullivan, J | 1 |
| Shiihara, T | 1 |
| Kato, M | 1 |
| Hayasaka, K | 1 |
3 other studies available for fluorouracil and Mitochondrial Diseases
| Article | Year |
|---|---|
Hepatectomy for liver metastasis from rectal cancer in a patient with mitochondrial disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Diabetes Mellitus, Type 2; Fema | 2021 |
Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bystander Effect; Colorectal Neoplasms; Combin | 2009 |
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion.
Topics: Adolescent; Brain Diseases, Metabolic; Corpus Callosum; Diagnosis, Differential; DNA, Mitochondrial; | 2005 |