fluorouracil and Milk-Alkali Syndrome
fluorouracil has been researched along with Milk-Alkali Syndrome in 14 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"To clarify the potential of parathyroid hormone-related protein (PTHrP) and interleukin-6 (IL-6) as cachectic factors in a colon 26 model and the effects of capecitabine on cancer cachexia as determined by plasma levels of IL-6 and PTHrP and body weight loss." | 7.74 | Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models. ( Fujimoto-Ouchi, K; Mori, K; Onuma, E; Shirane, M; Tanaka, Y, 2007) |
"To clarify the potential of parathyroid hormone-related protein (PTHrP) and interleukin-6 (IL-6) as cachectic factors in a colon 26 model and the effects of capecitabine on cancer cachexia as determined by plasma levels of IL-6 and PTHrP and body weight loss." | 3.74 | Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models. ( Fujimoto-Ouchi, K; Mori, K; Onuma, E; Shirane, M; Tanaka, Y, 2007) |
"Hypercalcemia is mainly caused by bone resorption due to either secretion of cytokines including parathyroid hormone-related protein (PTHrP) or bone metastases." | 1.38 | Impact of chemotherapy on hypercalcemia in breast and lung cancer patients. ( Hassali, MA; Hassan, BA; Othman, SB; Weiderpass, E; Yusoff, ZB, 2012) |
"We report two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia." | 1.35 | [Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia]. ( Kobayashi, Y; Matsuzaki, A; Terauchi, F; Washino, S, 2008) |
"Hypercalcemia is the most common metabolic disorder associated with malignancies." | 1.30 | Hypercalcemia and carcinoma of the penis. ( Ago, CT; Videtic, GM; Winquist, EW, 1997) |
"Hypercalcemia was previously considered a terminal phenomenon in advanced head and neck squamous-cell carcinoma." | 1.28 | Hypercalcemia in head and neck squamous-cell carcinoma. ( Hussein, AM; Sridhar, KS, 1990) |
Research
Studies (14)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (35.71) | 18.7374 |
1990's | 4 (28.57) | 18.2507 |
2000's | 3 (21.43) | 29.6817 |
2010's | 2 (14.29) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Washino, S | 1 |
Terauchi, F | 1 |
Matsuzaki, A | 1 |
Kobayashi, Y | 1 |
Lin, PH | 1 |
Chiu, CF | 1 |
Lu, YS | 1 |
Hassan, BA | 1 |
Yusoff, ZB | 1 |
Hassali, MA | 1 |
Othman, SB | 1 |
Weiderpass, E | 1 |
Fujimoto-Ouchi, K | 1 |
Onuma, E | 1 |
Shirane, M | 1 |
Mori, K | 1 |
Tanaka, Y | 1 |
Kaur, MR | 1 |
Marsden, JR | 1 |
Nelson, HM | 1 |
Videtic, GM | 1 |
Ago, CT | 1 |
Winquist, EW | 1 |
Iino, Y | 1 |
Yoshida, M | 1 |
Sugamata, N | 1 |
Maemura, M | 1 |
Ohwada, S | 1 |
Yokoe, T | 1 |
Ishikita, T | 1 |
Horiuchi, R | 1 |
Morishita, Y | 1 |
Bresler, L | 1 |
Boissel, P | 1 |
Conroy, T | 1 |
Grosdidier, J | 1 |
Sridhar, KS | 1 |
Hussein, AM | 1 |
Lowenthal, RM | 1 |
Jestrimski, KW | 1 |
Gardner, B | 1 |
Yagoda, A | 1 |
Tashima, CK | 1 |
Eras, P | 1 |
Sherlock, P | 1 |
Reviews
2 reviews available for fluorouracil and Milk-Alkali Syndrome
Article | Year |
---|---|
Corticosteroid drugs: their role in oncological practice.
Topics: Adrenal Cortex Hormones; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Breast | 1986 |
Proceedings: Non-hormonal cytotoxic agents in the treatment of prostatic adenocarcinoma.
Topics: Acid Phosphatase; Adenocarcinoma; Aniline Compounds; Bone Neoplasms; Cyclophosphamide; Evaluation St | 1973 |
Other Studies
12 other studies available for fluorouracil and Milk-Alkali Syndrome
Article | Year |
---|---|
[Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali | 2008 |
Cisplatin as an active treatment in zoledronate-refractory hypercalcemia.
Topics: Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Carcinoma | 2011 |
Impact of chemotherapy on hypercalcemia in breast and lung cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conserv | 2012 |
Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models.
Topics: Animals; Cachexia; Capecitabine; Cell Line; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Hypercal | 2007 |
Humoral hypercalcaemia of malignancy associated with primary cutaneous squamous cell carcinoma.
Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Fatal Outcome; Female; Fluorouraci | 2007 |
Hypercalcemia and carcinoma of the penis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Fluorouracil; H | 1997 |
1 alpha-hydroxyvitamin D3, hypercalcemia, and growth suppression of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Divi | 1992 |
Pancreatic islet cell carcinoma with hypercalcemia: complete remission 5 years after surgical excision and chemotherapy.
Topics: Adenoma, Islet Cell; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluo | 1991 |
Hypercalcemia in head and neck squamous-cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Female; Fluorou | 1990 |
Current concepts in the treatment of advanced breast cancer.
Topics: Adrenalectomy; Adult; Androgens; Breast Neoplasms; Castration; Estrogens; Female; Fluorouracil; Huma | 1972 |
Hypercalcemia in cancer: response to therapy.
Topics: Adenocarcinoma; Adult; Allopurinol; Antineoplastic Agents; Calcium; Cyclophosphamide; Fluorouracil; | 1974 |
Hepatic coma secondary to metastatic liver disease.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Breast Neoplasms; Colonic Neoplasms; Fluorouracil | 1971 |