Page last updated: 2024-10-27

fluorouracil and Milk-Alkali Syndrome

fluorouracil has been researched along with Milk-Alkali Syndrome in 14 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"To clarify the potential of parathyroid hormone-related protein (PTHrP) and interleukin-6 (IL-6) as cachectic factors in a colon 26 model and the effects of capecitabine on cancer cachexia as determined by plasma levels of IL-6 and PTHrP and body weight loss."7.74Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models. ( Fujimoto-Ouchi, K; Mori, K; Onuma, E; Shirane, M; Tanaka, Y, 2007)
"To clarify the potential of parathyroid hormone-related protein (PTHrP) and interleukin-6 (IL-6) as cachectic factors in a colon 26 model and the effects of capecitabine on cancer cachexia as determined by plasma levels of IL-6 and PTHrP and body weight loss."3.74Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models. ( Fujimoto-Ouchi, K; Mori, K; Onuma, E; Shirane, M; Tanaka, Y, 2007)
"Hypercalcemia is mainly caused by bone resorption due to either secretion of cytokines including parathyroid hormone-related protein (PTHrP) or bone metastases."1.38Impact of chemotherapy on hypercalcemia in breast and lung cancer patients. ( Hassali, MA; Hassan, BA; Othman, SB; Weiderpass, E; Yusoff, ZB, 2012)
"We report two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia."1.35[Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia]. ( Kobayashi, Y; Matsuzaki, A; Terauchi, F; Washino, S, 2008)
"Hypercalcemia is the most common metabolic disorder associated with malignancies."1.30Hypercalcemia and carcinoma of the penis. ( Ago, CT; Videtic, GM; Winquist, EW, 1997)
"Hypercalcemia was previously considered a terminal phenomenon in advanced head and neck squamous-cell carcinoma."1.28Hypercalcemia in head and neck squamous-cell carcinoma. ( Hussein, AM; Sridhar, KS, 1990)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19905 (35.71)18.7374
1990's4 (28.57)18.2507
2000's3 (21.43)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Washino, S1
Terauchi, F1
Matsuzaki, A1
Kobayashi, Y1
Lin, PH1
Chiu, CF1
Lu, YS1
Hassan, BA1
Yusoff, ZB1
Hassali, MA1
Othman, SB1
Weiderpass, E1
Fujimoto-Ouchi, K1
Onuma, E1
Shirane, M1
Mori, K1
Tanaka, Y1
Kaur, MR1
Marsden, JR1
Nelson, HM1
Videtic, GM1
Ago, CT1
Winquist, EW1
Iino, Y1
Yoshida, M1
Sugamata, N1
Maemura, M1
Ohwada, S1
Yokoe, T1
Ishikita, T1
Horiuchi, R1
Morishita, Y1
Bresler, L1
Boissel, P1
Conroy, T1
Grosdidier, J1
Sridhar, KS1
Hussein, AM1
Lowenthal, RM1
Jestrimski, KW1
Gardner, B1
Yagoda, A1
Tashima, CK1
Eras, P1
Sherlock, P1

Reviews

2 reviews available for fluorouracil and Milk-Alkali Syndrome

ArticleYear
Corticosteroid drugs: their role in oncological practice.
    The Medical journal of Australia, 1986, Jan-20, Volume: 144, Issue:2

    Topics: Adrenal Cortex Hormones; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Breast

1986
Proceedings: Non-hormonal cytotoxic agents in the treatment of prostatic adenocarcinoma.
    Cancer, 1973, Volume: 32, Issue:5

    Topics: Acid Phosphatase; Adenocarcinoma; Aniline Compounds; Bone Neoplasms; Cyclophosphamide; Evaluation St

1973

Other Studies

12 other studies available for fluorouracil and Milk-Alkali Syndrome

ArticleYear
[Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 2008, Volume: 99, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali

2008
Cisplatin as an active treatment in zoledronate-refractory hypercalcemia.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:5

    Topics: Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Carcinoma

2011
Impact of chemotherapy on hypercalcemia in breast and lung cancer patients.
    Asian Pacific journal of cancer prevention : APJCP, 2012, Volume: 13, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conserv

2012
Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models.
    Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:6

    Topics: Animals; Cachexia; Capecitabine; Cell Line; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Hypercal

2007
Humoral hypercalcaemia of malignancy associated with primary cutaneous squamous cell carcinoma.
    Clinical and experimental dermatology, 2007, Volume: 32, Issue:2

    Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Fatal Outcome; Female; Fluorouraci

2007
Hypercalcemia and carcinoma of the penis.
    Medical and pediatric oncology, 1997, Volume: 29, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Fluorouracil; H

1997
1 alpha-hydroxyvitamin D3, hypercalcemia, and growth suppression of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.
    Breast cancer research and treatment, 1992, Volume: 22, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Divi

1992
Pancreatic islet cell carcinoma with hypercalcemia: complete remission 5 years after surgical excision and chemotherapy.
    The American journal of gastroenterology, 1991, Volume: 86, Issue:5

    Topics: Adenoma, Islet Cell; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluo

1991
Hypercalcemia in head and neck squamous-cell carcinoma.
    American journal of clinical oncology, 1990, Volume: 13, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Female; Fluorou

1990
Current concepts in the treatment of advanced breast cancer.
    Oncology, 1972, Volume: 26, Issue:2

    Topics: Adrenalectomy; Adult; Androgens; Breast Neoplasms; Castration; Estrogens; Female; Fluorouracil; Huma

1972
Hypercalcemia in cancer: response to therapy.
    American family physician, 1974, Volume: 10, Issue:5

    Topics: Adenocarcinoma; Adult; Allopurinol; Antineoplastic Agents; Calcium; Cyclophosphamide; Fluorouracil;

1974
Hepatic coma secondary to metastatic liver disease.
    Annals of internal medicine, 1971, Volume: 74, Issue:4

    Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Breast Neoplasms; Colonic Neoplasms; Fluorouracil

1971
chemdatabank.com