fluorouracil has been researched along with Middle Ear Effusion in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our aim was to evaluate the combined effect of 5-fluorouracil (5-FU) and myringotomy for the treatment of otitis media with effusion (OME)." | 7.74 | 5-Fluorouracil ointment for the treatment of otitis media with effusion. ( Ito, J; Kanemaru, S; Magrfov, A; Nakamura, T; Omori, K; Yamashita, M, 2007) |
| "Our aim was to evaluate the combined effect of 5-fluorouracil (5-FU) and myringotomy for the treatment of otitis media with effusion (OME)." | 3.74 | 5-Fluorouracil ointment for the treatment of otitis media with effusion. ( Ito, J; Kanemaru, S; Magrfov, A; Nakamura, T; Omori, K; Yamashita, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cincik, H | 1 |
| Güngör, A | 1 |
| Sağlam, O | 1 |
| Cekin, E | 1 |
| Yildirim, S | 1 |
| Poyrazoğlu, E | 1 |
| Kanemaru, S | 1 |
| Nakamura, T | 1 |
| Yamashita, M | 1 |
| Magrfov, A | 1 |
| Omori, K | 1 |
| Ito, J | 1 |
2 other studies available for fluorouracil and Middle Ear Effusion
| Article | Year |
|---|---|
Effective dose of 5-fluorouracil for myringotomy in rats.
Topics: Animals; Antimetabolites; Dose-Response Relationship, Drug; Fibrosis; Fluorouracil; Inflammation; Mi | 2005 |
5-Fluorouracil ointment for the treatment of otitis media with effusion.
Topics: Administration, Topical; Adolescent; Adult; Aged; Animals; Antimetabolites; Cell Proliferation; Cell | 2007 |