Page last updated: 2024-10-27
fluorouracil and Microscopic Colitis
fluorouracil has been researched along with Microscopic Colitis in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| " Aflibercept is used for the treatment of metastatic colorectal cancer (mCRC) in association with irinotecan." | 7.81 | Fluorouracil, leucovorin and irinotecan associated with aflibercept can induce microscopic colitis in metastatic colorectal cancer patients. ( Beltjens, F; Bengrine, L; Ghiringhelli, F; Ladoire, S; Vincent, J, 2015) |
| " Aflibercept is used for the treatment of metastatic colorectal cancer (mCRC) in association with irinotecan." | 3.81 | Fluorouracil, leucovorin and irinotecan associated with aflibercept can induce microscopic colitis in metastatic colorectal cancer patients. ( Beltjens, F; Bengrine, L; Ghiringhelli, F; Ladoire, S; Vincent, J, 2015) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Ghiringhelli, F | 1 |
| Vincent, J | 1 |
| Beltjens, F | 1 |
| Bengrine, L | 1 |
| Ladoire, S | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.[NCT04392479] | Phase 3 | 202 participants (Anticipated) | Interventional | 2020-09-02 | Active, not recruiting |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Other Studies
1 other study available for fluorouracil and Microscopic Colitis