fluorouracil has been researched along with Micrometastases, Neoplasm in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "MAI (≥ 10) was strongly associated with breast cancer-related death in lymph node (LN)-negative patients (hazard ratio (HR): 7." | 2.76 | Mitotic activity and bone marrow micrometastases have independent prognostic value in node positive breast cancer patients. ( Baak, JP; Gilje, B; Janssen, EA; Nordgård, O; Smaaland, R; Søiland, H; Tjensvoll, K, 2011) |
| " Dosing and completion of prescribed chemotherapy were assessed on the subset of patients who received all therapy at MSK." | 1.48 | Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer. ( Cercek, A; Crane, CH; Garcia-Aguilar, J; Gollub, MJ; Gonen, M; Guillem, JG; Nash, GM; Paty, PB; Reidy, DL; Roxburgh, CSD; Saltz, LB; Segal, NH; Seier, K; Shia, J; Smith, JJ; Stadler, ZK; Strombom, P; Temple, LKF; Vakiani, E; Varghese, A; Weiser, MR; Wu, AJ; Yaeger, R, 2018) |
| "Of them, 315 node-negative stage II colorectal cancer cases were enrolled." | 1.43 | Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial. ( Doki, Y; Fukunaga, M; Ikeda, M; Kato, T; Matsuura, N; Miyake, Y; Mizushima, T; Monden, M; Mori, M; Murata, K; Nakamura, Y; Nezu, R; Noura, S; Ohnishi, T; Ohtsuka, M; Ohue, M; Sekimoto, M; Takemasa, I; Yamamoto, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cercek, A | 1 |
| Roxburgh, CSD | 1 |
| Strombom, P | 1 |
| Smith, JJ | 1 |
| Temple, LKF | 1 |
| Nash, GM | 1 |
| Guillem, JG | 1 |
| Paty, PB | 1 |
| Yaeger, R | 1 |
| Stadler, ZK | 1 |
| Seier, K | 1 |
| Gonen, M | 1 |
| Segal, NH | 1 |
| Reidy, DL | 1 |
| Varghese, A | 1 |
| Shia, J | 1 |
| Vakiani, E | 1 |
| Wu, AJ | 1 |
| Crane, CH | 1 |
| Gollub, MJ | 1 |
| Garcia-Aguilar, J | 1 |
| Saltz, LB | 1 |
| Weiser, MR | 1 |
| Touil, Y | 1 |
| Igoudjil, W | 1 |
| Corvaisier, M | 1 |
| Dessein, AF | 1 |
| Vandomme, J | 1 |
| Monté, D | 1 |
| Stechly, L | 1 |
| Skrypek, N | 1 |
| Langlois, C | 1 |
| Grard, G | 1 |
| Millet, G | 1 |
| Leteurtre, E | 1 |
| Dumont, P | 1 |
| Truant, S | 1 |
| Pruvot, FR | 1 |
| Hebbar, M | 1 |
| Fan, F | 1 |
| Ellis, LM | 1 |
| Formstecher, P | 1 |
| Van Seuningen, I | 1 |
| Gespach, C | 1 |
| Polakowska, R | 1 |
| Huet, G | 1 |
| Yamamoto, H | 1 |
| Murata, K | 1 |
| Fukunaga, M | 1 |
| Ohnishi, T | 1 |
| Noura, S | 1 |
| Miyake, Y | 1 |
| Kato, T | 1 |
| Ohtsuka, M | 1 |
| Nakamura, Y | 1 |
| Takemasa, I | 1 |
| Mizushima, T | 1 |
| Ikeda, M | 1 |
| Ohue, M | 1 |
| Sekimoto, M | 1 |
| Nezu, R | 1 |
| Matsuura, N | 1 |
| Monden, M | 1 |
| Doki, Y | 1 |
| Mori, M | 1 |
| Boston, EA | 1 |
| Gaffney, EA | 1 |
| Gilje, B | 1 |
| Nordgård, O | 1 |
| Tjensvoll, K | 1 |
| Janssen, EA | 1 |
| Søiland, H | 1 |
| Smaaland, R | 1 |
| Baak, JP | 1 |
1 trial available for fluorouracil and Micrometastases, Neoplasm
| Article | Year |
|---|---|
Mitotic activity and bone marrow micrometastases have independent prognostic value in node positive breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasm | 2011 |
4 other studies available for fluorouracil and Micrometastases, Neoplasm
| Article | Year |
|---|---|
Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradiotherap | 2018 |
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.
Topics: Antimetabolites, Antineoplastic; Biomarkers, Tumor; Cell Cycle Checkpoints; Cell Cycle Proteins; Cel | 2014 |
Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial.
Topics: Aged; Antineoplastic Agents; Biomarkers, Tumor; Carcinoembryonic Antigen; Colorectal Neoplasms; Dise | 2016 |
The influence of toxicity constraints in models of chemotherapeutic protocol escalation.
Topics: Antineoplastic Agents; Antineoplastic Protocols; Cell Cycle; Colorectal Neoplasms; Drug Administrati | 2011 |