fluorouracil has been researched along with Metaplasia in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This case report describes a patient with cutaneous intestinal metaplasia with invasive adenocarcinoma treated successfully with intralesional fluorouracil." | 8.31 | Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil. ( Dahiya, M; Eilers, D; Joseph, MX; Tao, J; Vaudreuil, A, 2023) |
| "To investigate the ocular surface changes occurring in eyes with recurrent pterygium post-operatively treated with 5-fluorouracil intralesional injections." | 7.91 | Ocular surface changes in recurrent pterygium cases post-operatively treated with 5-fluorouracil subconjunctival injections. ( Boto de Los Bueis, A; García Tirado, A; Rivas Jara, L, 2019) |
| "Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia." | 7.71 | Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report. ( Agarwal, MR; Burnstine, MA; Esmaeli, B, 2002) |
| "This case report describes a patient with cutaneous intestinal metaplasia with invasive adenocarcinoma treated successfully with intralesional fluorouracil." | 4.31 | Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil. ( Dahiya, M; Eilers, D; Joseph, MX; Tao, J; Vaudreuil, A, 2023) |
| "To investigate the ocular surface changes occurring in eyes with recurrent pterygium post-operatively treated with 5-fluorouracil intralesional injections." | 3.91 | Ocular surface changes in recurrent pterygium cases post-operatively treated with 5-fluorouracil subconjunctival injections. ( Boto de Los Bueis, A; García Tirado, A; Rivas Jara, L, 2019) |
| "Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia." | 3.71 | Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report. ( Agarwal, MR; Burnstine, MA; Esmaeli, B, 2002) |
| "Metaplastic breast cancer is a rare disease with little information available to guide therapy." | 1.30 | Metaplastic breast cancer: prognosis and response to systemic therapy. ( Adjei, AA; Ingle, JN; Rayson, D; Suman, VJ; Wold, LE, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tao, J | 3 |
| Joseph, MX | 3 |
| Vaudreuil, A | 3 |
| Dahiya, M | 3 |
| Eilers, D | 3 |
| Radyk, MD | 1 |
| Burclaff, J | 1 |
| Willet, SG | 1 |
| Mills, JC | 1 |
| García Tirado, A | 1 |
| Boto de Los Bueis, A | 1 |
| Rivas Jara, L | 1 |
| Simsek, T | 1 |
| Firat, P | 1 |
| Citirik, M | 1 |
| Ozdamar, Y | 1 |
| Elgin, U | 1 |
| Agarwal, MR | 1 |
| Esmaeli, B | 1 |
| Burnstine, MA | 1 |
| Kaneyasu, Y | 1 |
| Okawa, T | 1 |
| Yajima, M | 1 |
| Saito, R | 1 |
| Nakabayashi, M | 1 |
| Seshimo, A | 1 |
| Kameoka, S | 1 |
| Aomi, S | 1 |
| Nishikawa, T | 1 |
| Sawada, T | 1 |
| Mitsuhashi, N | 1 |
| Dungar, CF | 1 |
| Wilkinson, EJ | 1 |
| van Slooten, HJ | 1 |
| Clahsen, PC | 1 |
| van Dierendonck, JH | 1 |
| Duval, C | 1 |
| Pallud, C | 1 |
| Mandard, AM | 1 |
| Delobelle-Deroide, A | 1 |
| van de Velde, CJ | 1 |
| van de Vijver, MJ | 1 |
| Rayson, D | 1 |
| Adjei, AA | 1 |
| Suman, VJ | 1 |
| Wold, LE | 1 |
| Ingle, JN | 1 |
| Haie-Meder, C | 1 |
| Lhommé, C | 1 |
| de Crevoisier, R | 1 |
| Morice, P | 1 |
| Resbeut, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Alpelisib With iNOS Inhibitor and Nab-paclitaxel in Patients With HER2 Negative Metastatic or Locally Advanced Metaplastic Breast Cancer (MpBC)[NCT05660083] | Phase 2 | 36 participants (Anticipated) | Interventional | 2023-01-12 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Metaplasia
| Article | Year |
|---|---|
[Concomitant radiochemotherapy in cancer of the cervix uteri: modifications of the standards].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; | 2000 |
1 trial available for fluorouracil and Metaplasia
| Article | Year |
|---|---|
Expression of Bcl-2 in node-negative breast cancer is associated with various prognostic factors, but does not predict response to one course of perioperative chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Carcinoma in Situ; Carcino | 1996 |
8 other studies available for fluorouracil and Metaplasia
| Article | Year |
|---|---|
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms | 2023 |
Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Cell Lineage; Cell Proliferation; Cell Transdifferentiat | 2018 |
Ocular surface changes in recurrent pterygium cases post-operatively treated with 5-fluorouracil subconjunctival injections.
Topics: Adult; Antimetabolites; Conjunctiva; Cornea; Epithelial Cells; Female; Fluorouracil; Follow-Up Studi | 2019 |
Short-term effects of subconjunctival injections of 5-fluorouracil on conjunctival epithelium.
Topics: Adult; Aged; Antimetabolites; Apoptosis; Conjunctiva; Epithelium; Female; Fluorouracil; Glaucoma, Op | 2010 |
Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report.
Topics: Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dacryocystorhinostomy; Epithelial Cells; F | 2002 |
Stage IVB uterine endometrial cancer successfully salvaged by chemoradiotherapy and surgery.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Endometrial Neoplasms; | 2003 |
Vaginal columnar cell metaplasia. An acquired adenosis associated with topical 5-fluorouracil therapy.
Topics: Adult; Epithelial Cells; Epithelium; Female; Fluorouracil; Humans; Metaplasia; Middle Aged; Papillom | 1995 |
Metaplastic breast cancer: prognosis and response to systemic therapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ca | 1999 |