Page last updated: 2024-10-27

fluorouracil and Metaplasia

fluorouracil has been researched along with Metaplasia in 10 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.

Research Excerpts

ExcerptRelevanceReference
"This case report describes a patient with cutaneous intestinal metaplasia with invasive adenocarcinoma treated successfully with intralesional fluorouracil."8.31Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil. ( Dahiya, M; Eilers, D; Joseph, MX; Tao, J; Vaudreuil, A, 2023)
"To investigate the ocular surface changes occurring in eyes with recurrent pterygium post-operatively treated with 5-fluorouracil intralesional injections."7.91Ocular surface changes in recurrent pterygium cases post-operatively treated with 5-fluorouracil subconjunctival injections. ( Boto de Los Bueis, A; García Tirado, A; Rivas Jara, L, 2019)
"Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia."7.71Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report. ( Agarwal, MR; Burnstine, MA; Esmaeli, B, 2002)
"This case report describes a patient with cutaneous intestinal metaplasia with invasive adenocarcinoma treated successfully with intralesional fluorouracil."4.31Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil. ( Dahiya, M; Eilers, D; Joseph, MX; Tao, J; Vaudreuil, A, 2023)
"To investigate the ocular surface changes occurring in eyes with recurrent pterygium post-operatively treated with 5-fluorouracil intralesional injections."3.91Ocular surface changes in recurrent pterygium cases post-operatively treated with 5-fluorouracil subconjunctival injections. ( Boto de Los Bueis, A; García Tirado, A; Rivas Jara, L, 2019)
"Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia."3.71Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report. ( Agarwal, MR; Burnstine, MA; Esmaeli, B, 2002)
"Metaplastic breast cancer is a rare disease with little information available to guide therapy."1.30Metaplastic breast cancer: prognosis and response to systemic therapy. ( Adjei, AA; Ingle, JN; Rayson, D; Suman, VJ; Wold, LE, 1999)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's3 (30.00)29.6817
2010's3 (30.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Tao, J3
Joseph, MX3
Vaudreuil, A3
Dahiya, M3
Eilers, D3
Radyk, MD1
Burclaff, J1
Willet, SG1
Mills, JC1
García Tirado, A1
Boto de Los Bueis, A1
Rivas Jara, L1
Simsek, T1
Firat, P1
Citirik, M1
Ozdamar, Y1
Elgin, U1
Agarwal, MR1
Esmaeli, B1
Burnstine, MA1
Kaneyasu, Y1
Okawa, T1
Yajima, M1
Saito, R1
Nakabayashi, M1
Seshimo, A1
Kameoka, S1
Aomi, S1
Nishikawa, T1
Sawada, T1
Mitsuhashi, N1
Dungar, CF1
Wilkinson, EJ1
van Slooten, HJ1
Clahsen, PC1
van Dierendonck, JH1
Duval, C1
Pallud, C1
Mandard, AM1
Delobelle-Deroide, A1
van de Velde, CJ1
van de Vijver, MJ1
Rayson, D1
Adjei, AA1
Suman, VJ1
Wold, LE1
Ingle, JN1
Haie-Meder, C1
Lhommé, C1
de Crevoisier, R1
Morice, P1
Resbeut, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Trial of Alpelisib With iNOS Inhibitor and Nab-paclitaxel in Patients With HER2 Negative Metastatic or Locally Advanced Metaplastic Breast Cancer (MpBC)[NCT05660083]Phase 236 participants (Anticipated)Interventional2023-01-12Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and Metaplasia

ArticleYear
[Concomitant radiochemotherapy in cancer of the cervix uteri: modifications of the standards].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2000, Volume: 4 Suppl 1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin;

2000

Trials

1 trial available for fluorouracil and Metaplasia

ArticleYear
Expression of Bcl-2 in node-negative breast cancer is associated with various prognostic factors, but does not predict response to one course of perioperative chemotherapy.
    British journal of cancer, 1996, Volume: 74, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Carcinoma in Situ; Carcino

1996

Other Studies

8 other studies available for fluorouracil and Metaplasia

ArticleYear
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Adenocarcinoma; Fluorouracil; Humans; Metaplasia; Skin; Stomach Neoplasms

2023
Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.
    Gastroenterology, 2018, Volume: 154, Issue:4

    Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Cell Lineage; Cell Proliferation; Cell Transdifferentiat

2018
Ocular surface changes in recurrent pterygium cases post-operatively treated with 5-fluorouracil subconjunctival injections.
    European journal of ophthalmology, 2019, Volume: 29, Issue:1

    Topics: Adult; Antimetabolites; Conjunctiva; Cornea; Epithelial Cells; Female; Fluorouracil; Follow-Up Studi

2019
Short-term effects of subconjunctival injections of 5-fluorouracil on conjunctival epithelium.
    Cornea, 2010, Volume: 29, Issue:7

    Topics: Adult; Aged; Antimetabolites; Apoptosis; Conjunctiva; Epithelium; Female; Fluorouracil; Glaucoma, Op

2010
Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report.
    Ophthalmology, 2002, Volume: 109, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dacryocystorhinostomy; Epithelial Cells; F

2002
Stage IVB uterine endometrial cancer successfully salvaged by chemoradiotherapy and surgery.
    International journal of clinical oncology, 2003, Volume: 8, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Endometrial Neoplasms;

2003
Vaginal columnar cell metaplasia. An acquired adenosis associated with topical 5-fluorouracil therapy.
    The Journal of reproductive medicine, 1995, Volume: 40, Issue:5

    Topics: Adult; Epithelial Cells; Epithelium; Female; Fluorouracil; Humans; Metaplasia; Middle Aged; Papillom

1995
Metaplastic breast cancer: prognosis and response to systemic therapy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ca

1999