fluorouracil has been researched along with Merkel Cell Cancer in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among the 252 cases, there were 110 carcinoids (43." | 1.39 | [Neuroendocrine tumors: analysis of 252 cases]. ( Chi, YH; Du, F; Jiang, WC; Song, Y; Sun, YK; Wang, JW; Yang, L; Zhou, AP, 2013) |
| "Merkel cell carcinoma is a rare and highly aggressive skin tumor." | 1.30 | The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma. ( Brenner, B; Fenig, E; Hana, MB; Katz, A; Rakovsky, E; Sulkes, A, 1997) |
| "Five patients with advanced Merkel cell carcinoma (MCC) are described." | 1.29 | The use of cyclophosphamide, methotrexate, and 5-fluorouracil in the treatment of Merkel cell carcinoma. ( Fenig, E; Lurie, H; Sulkes, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chi, YH | 1 |
| Jiang, WC | 1 |
| Du, F | 1 |
| Sun, YK | 1 |
| Song, Y | 1 |
| Yang, L | 1 |
| Zhou, AP | 1 |
| Wang, JW | 1 |
| Dummer, R | 1 |
| Beyeler, M | 1 |
| Morcinek, J | 1 |
| Burg, G | 1 |
| Fenig, E | 3 |
| Nordenberg, J | 1 |
| Beery, E | 1 |
| Sulkes, J | 1 |
| Wasserman, L | 1 |
| King, MM | 1 |
| Osswald, MB | 1 |
| Lurie, H | 1 |
| Sulkes, A | 2 |
| Brenner, B | 1 |
| Katz, A | 1 |
| Rakovsky, E | 1 |
| Hana, MB | 1 |
1 review available for fluorouracil and Merkel Cell Cancer
| Article | Year |
|---|---|
[Cutaneous neoplasms].
Topics: Adjuvants, Immunologic; Aminoquinolines; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bio | 2003 |
5 other studies available for fluorouracil and Merkel Cell Cancer
| Article | Year |
|---|---|
[Neuroendocrine tumors: analysis of 252 cases].
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protoc | 2013 |
Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma.
Topics: Antineoplastic Agents; Benzamides; Carcinoma, Merkel Cell; Cell Adhesion; Cell Division; Cell Line, | 2004 |
Adjuvant chemotherapy for Merkel cell carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Merkel Cell; Chemotherapy, Adjuvant | 2005 |
The use of cyclophosphamide, methotrexate, and 5-fluorouracil in the treatment of Merkel cell carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Merkel Cell; Cyclophosphamid | 1993 |
The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols | 1997 |