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fluorouracil and Merkel Cell Cancer

fluorouracil has been researched along with Merkel Cell Cancer in 6 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Among the 252 cases, there were 110 carcinoids (43."1.39[Neuroendocrine tumors: analysis of 252 cases]. ( Chi, YH; Du, F; Jiang, WC; Song, Y; Sun, YK; Wang, JW; Yang, L; Zhou, AP, 2013)
"Merkel cell carcinoma is a rare and highly aggressive skin tumor."1.30The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma. ( Brenner, B; Fenig, E; Hana, MB; Katz, A; Rakovsky, E; Sulkes, A, 1997)
"Five patients with advanced Merkel cell carcinoma (MCC) are described."1.29The use of cyclophosphamide, methotrexate, and 5-fluorouracil in the treatment of Merkel cell carcinoma. ( Fenig, E; Lurie, H; Sulkes, A, 1993)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chi, YH1
Jiang, WC1
Du, F1
Sun, YK1
Song, Y1
Yang, L1
Zhou, AP1
Wang, JW1
Dummer, R1
Beyeler, M1
Morcinek, J1
Burg, G1
Fenig, E3
Nordenberg, J1
Beery, E1
Sulkes, J1
Wasserman, L1
King, MM1
Osswald, MB1
Lurie, H1
Sulkes, A2
Brenner, B1
Katz, A1
Rakovsky, E1
Hana, MB1

Reviews

1 review available for fluorouracil and Merkel Cell Cancer

ArticleYear
[Cutaneous neoplasms].
    Praxis, 2003, Sep-03, Volume: 92, Issue:36

    Topics: Adjuvants, Immunologic; Aminoquinolines; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bio

2003

Other Studies

5 other studies available for fluorouracil and Merkel Cell Cancer

ArticleYear
[Neuroendocrine tumors: analysis of 252 cases].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protoc

2013
Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma.
    Oncology reports, 2004, Volume: 11, Issue:1

    Topics: Antineoplastic Agents; Benzamides; Carcinoma, Merkel Cell; Cell Adhesion; Cell Division; Cell Line,

2004
Adjuvant chemotherapy for Merkel cell carcinoma.
    American journal of clinical oncology, 2005, Volume: 28, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Merkel Cell; Chemotherapy, Adjuvant

2005
The use of cyclophosphamide, methotrexate, and 5-fluorouracil in the treatment of Merkel cell carcinoma.
    American journal of clinical oncology, 1993, Volume: 16, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Merkel Cell; Cyclophosphamid

1993
The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma.
    Cancer, 1997, Sep-01, Volume: 80, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols

1997