Page last updated: 2024-10-27

fluorouracil and Menopause, Premature

fluorouracil has been researched along with Menopause, Premature in 4 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Menopause, Premature: The premature cessation of menses (MENSTRUATION) when the last menstrual period occurs in a woman under the age of 40. It is due to the depletion of OVARIAN FOLLICLES. Premature MENOPAUSE can be caused by diseases; OVARIECTOMY; RADIATION; chemicals; and chromosomal abnormalities.

Research Excerpts

ExcerptRelevanceReference
"To compare dose-intensified epirubicin monotherapy with a standard sequential regimen, patients with primary breast cancer and > or =10 involved axillary nodes were randomised to either four 21-day cycles of epirubicin 120 mg/m(2) (E120; n=202) or four 21-day cycles of epirubicin 90 mg/m(2) plus cyclophosphamide 600 mg/m(2) (EC) followed by three 28-day cycles of cyclophosphamide, methotrexate and 5-fluorouracil (CMF; n=209)."9.14Dose-intensified epirubicin versus standard-dose epirubicin/cyclophosphamide followed by CMF in breast cancer patients with 10 or more positive lymph nodes: results of a randomised trial (GABG-IV E-93) - the German Adjuvant Breast Cancer Group. ( Ataseven, B; Conrad, B; Eiermann, W; Graf, E; Hilfrich, J; Kaufmann, M; Loibl, S; Massinger-Biebl, H; Schumacher, M; Vescia, S; von Minckwitz, G, 2010)
"To compare dose-intensified epirubicin monotherapy with a standard sequential regimen, patients with primary breast cancer and > or =10 involved axillary nodes were randomised to either four 21-day cycles of epirubicin 120 mg/m(2) (E120; n=202) or four 21-day cycles of epirubicin 90 mg/m(2) plus cyclophosphamide 600 mg/m(2) (EC) followed by three 28-day cycles of cyclophosphamide, methotrexate and 5-fluorouracil (CMF; n=209)."5.14Dose-intensified epirubicin versus standard-dose epirubicin/cyclophosphamide followed by CMF in breast cancer patients with 10 or more positive lymph nodes: results of a randomised trial (GABG-IV E-93) - the German Adjuvant Breast Cancer Group. ( Ataseven, B; Conrad, B; Eiermann, W; Graf, E; Hilfrich, J; Kaufmann, M; Loibl, S; Massinger-Biebl, H; Schumacher, M; Vescia, S; von Minckwitz, G, 2010)
"Premenopausal women with breast cancer often enter a premature menopause during initial treatment of their malignancy, with resulting loss of childbearing capacity, onset of menopausal symptoms, and subsequent prolonged exposure to long-term risks of menopause."1.30Risk of menopause during the first year after breast cancer diagnosis. ( Ennis, M; Goodwin, PJ; Hood, N; Pritchard, KI; Trudeau, M, 1999)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pritchard, KI2
Eiermann, W1
Graf, E1
Ataseven, B1
Conrad, B1
Hilfrich, J1
Massinger-Biebl, H1
Vescia, S1
Loibl, S1
von Minckwitz, G1
Schumacher, M1
Kaufmann, M1
Goodwin, PJ1
Ennis, M1
Trudeau, M1
Hood, N1
Koyama, H1
Wada, T1
Nishizawa, Y1
Iwanaga, T1
Aoki, Y1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Trial of Internet-based Cognitive Behavioral Therapy for Breast Cancer Patients With Climacteric Symptoms[NCT02672189]Phase 3254 participants (Actual)Interventional2015-02-28Completed
Ovarian Tissue Freezing For Fertility Preservation In Women Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen: A Study By The National Physicians Cooperative of the Oncofertility Consortium At Northwestern University[NCT00902720]Phase 425 participants (Anticipated)Interventional2009-05-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and Menopause, Premature

ArticleYear
Ovarian suppression/ablation in premenopausal ER-positive breast cancer patients. Issues and recommendations.
    Oncology (Williston Park, N.Y.), 2009, Volume: 23, Issue:1

    Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase In

2009

Trials

1 trial available for fluorouracil and Menopause, Premature

ArticleYear
Dose-intensified epirubicin versus standard-dose epirubicin/cyclophosphamide followed by CMF in breast cancer patients with 10 or more positive lymph nodes: results of a randomised trial (GABG-IV E-93) - the German Adjuvant Breast Cancer Group.
    European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:1

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers

2010

Other Studies

2 other studies available for fluorouracil and Menopause, Premature

ArticleYear
Risk of menopause during the first year after breast cancer diagnosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:8

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cis

1999
Cyclophosphamide-induced ovarian failure and its therapeutic significance in patients with breast cancer.
    Cancer, 1977, Volume: 39, Issue:4

    Topics: Adult; Amenorrhea; Breast Neoplasms; Cyclophosphamide; Estrogens; Female; Fluorouracil; Follicle Sti

1977