fluorouracil has been researched along with Meningitis in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil." | 7.72 | Response of neoplastic meningitis from solid tumors to oral capecitabine. ( Giglio, P; Groves, MD; Tremont-Lukats, IW, 2003) |
| " We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil." | 3.72 | Response of neoplastic meningitis from solid tumors to oral capecitabine. ( Giglio, P; Groves, MD; Tremont-Lukats, IW, 2003) |
| " Although the neurotoxic effects produced by different cytostatics present a different appearance and are partly of only sporadic or slight clinical importance, there is hardly a cytostatic which does not exercise a side effect on the nervous system." | 1.26 | [Neurotoxic side effects of cytostatic therapy (author's transl)]. ( Maurach, R; Strian, F, 1981) |
| "Treatment with metyrapone decreased her cortisol production and produced clinical remission of Cushing's syndrome." | 1.25 | The immunological hazard of Cushing's syndrome. ( Britton, S; Sjoberg, HE; Thorén, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giglio, P | 1 |
| Tremont-Lukats, IW | 1 |
| Groves, MD | 1 |
| Strian, F | 1 |
| Maurach, R | 1 |
| Diasio, RB | 1 |
| Lakings, DE | 1 |
| Bennett, JE | 1 |
| Britton, S | 1 |
| Thorén, M | 1 |
| Sjoberg, HE | 1 |
| Graf, W | 1 |
| Holmgren, B | 1 |
5 other studies available for fluorouracil and Meningitis
| Article | Year |
|---|---|
Response of neoplastic meningitis from solid tumors to oral capecitabine.
Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcin | 2003 |
[Neurotoxic side effects of cytostatic therapy (author's transl)].
Topics: Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Dacarbazine; Dactinomycin; Doxoru | 1981 |
Evidence for conversion of 5-fluorocytosine to 5-fluorouracil in humans: possible factor in 5-fluorocytosine clinical toxicity.
Topics: Capsules; Cryptococcosis; Cytosine; Flucytosine; Fluorouracil; Humans; Kidney; Meningitis | 1978 |
The immunological hazard of Cushing's syndrome.
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Cryptococcosis; Cushing Syndrome; Female; Fluorouracil; Hum | 1975 |
[Letter: A dangerous mistake--name confusion].
Topics: Adult; Female; Flucytosine; Fluorouracil; Humans; Medication Errors; Meningitis; Publishing; Termino | 1976 |