fluorouracil has been researched along with Meningitis, Cryptococcal in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Meningitis, Cryptococcal: Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We provided pharmaceutical care for a cryptococcal meningitis case to study the role that clinical pharmacists played in clinical pharmacotherapy." | 1.35 | [Pharmaceutical care of patient with cryptococcal meningitis: a case report]. ( Li, CX; Liu, F; Zhai, SD; Zhang, XY, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Judd, WR | 1 |
| Shely, RN | 1 |
| Ratliff, PD | 1 |
| Reymann, MT | 1 |
| Li, CX | 1 |
| Liu, F | 1 |
| Zhang, XY | 1 |
| Zhai, SD | 1 |
| Vermes, A | 1 |
| Guchelaar, HJ | 1 |
| van Kuilenburg, AB | 1 |
| Dankert, J | 1 |
1 trial available for fluorouracil and Meningitis, Cryptococcal
| Article | Year |
|---|---|
5-fluorocytosine-related bone-marrow depression and conversion to fluorouracil: a pilot study.
Topics: Adult; Aged; beta-Alanine; Biotransformation; Bone Marrow; Candidiasis; Female; Flucytosine; Fluorou | 2002 |
2 other studies available for fluorouracil and Meningitis, Cryptococcal
| Article | Year |
|---|---|
False-negative cerebrospinal fluid fungal culture results following oral antineoplastic therapy with a 5-fluorouracil derivative.
Topics: Administration, Oral; Aged; Antineoplastic Agents; Capecitabine; Cerebrospinal Fluid; Cryptococcosis | 2015 |
[Pharmaceutical care of patient with cryptococcal meningitis: a case report].
Topics: Adult; Amphotericin B; Antifungal Agents; Drug Monitoring; Drug Therapy, Combination; Fluorouracil; | 2009 |