fluorouracil has been researched along with Meningioma in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Meningioma: A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine." | 7.69 | Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro. ( Muhr, C; Smits, A; Wang, JL; Zhang, ZJ, 1996) |
| "5T) was performed in 191 female CMF (Cyclophosphamide, Methotrexate, 5-Fluorouracil) chemotherapy-exposed breast cancer survivors." | 3.77 | Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy. ( Boogerd, W; Breteler, MM; Koppelmans, V; Poels, MM; Schagen, SB; Seynaeve, C; van der Lugt, A, 2011) |
| "Radiological and clinical evidence of acute necrosis in a meningioma following one cycle of chemotherapy with 5-fluorouracil, folinic acid, and levamisole was observed in a patient being treated for invasive rectal carcinoma." | 3.69 | Necrosis in a meningioma following systemic chemotherapy. Case report. ( Bernstein, M; Davidson, G; Erlichman, C; Villamil, A, 1994) |
| "We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine." | 3.69 | Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro. ( Muhr, C; Smits, A; Wang, JL; Zhang, ZJ, 1996) |
| "Nineteen patients with brain tumors were orally administered 300 mg of UFT (a combination of FT and uracil with a molar ratio being 1:4) before operation and the concentrations of FT, 5-FU and Uracil in tumors and serum were measured by chemical assay." | 1.27 | [5-FU concentration in brain tumors after co-administration of FT and uracil]. ( Matsumoto, S; Nogaki, H; Tamaki, N; Taomoto, K, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koppelmans, V | 1 |
| Schagen, SB | 1 |
| Poels, MM | 1 |
| Boogerd, W | 1 |
| Seynaeve, C | 1 |
| van der Lugt, A | 1 |
| Breteler, MM | 1 |
| Matsumoto, K | 1 |
| Tabuchi, K | 1 |
| Furuta, T | 1 |
| Fujiwara, T | 1 |
| Nakasone, S | 1 |
| Ohnishi, R | 1 |
| Moriya, Y | 1 |
| Nishimoto, A | 1 |
| Doi, A | 1 |
| Asari, S | 1 |
| Nogaki, H | 1 |
| Taomoto, K | 1 |
| Tamaki, N | 1 |
| Matsumoto, S | 1 |
| Bernstein, M | 1 |
| Villamil, A | 1 |
| Davidson, G | 1 |
| Erlichman, C | 1 |
| Zhang, ZJ | 1 |
| Wang, JL | 1 |
| Muhr, C | 1 |
| Smits, A | 1 |
| Sano, K | 1 |
| Hoshino, T | 1 |
| Nagai, M | 1 |
| Ringkjob, R | 1 |
7 other studies available for fluorouracil and Meningioma
| Article | Year |
|---|---|
Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brea | 2011 |
[Combination chemotherapy of brain tumors with ACNU and 5-FU].
Topics: Astrocytoma; Biological Products; Brain Neoplasms; Combined Modality Therapy; Drug Therapy, Combinat | 1983 |
[5-FU concentration in brain tumors after co-administration of FT and uracil].
Topics: Brain Neoplasms; Drug Therapy, Combination; Fluorouracil; Glioblastoma; Humans; Meningeal Neoplasms; | 1983 |
Necrosis in a meningioma following systemic chemotherapy. Case report.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Embolizat | 1994 |
Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carbon Radioisotopes; Cell Division; Drug Syn | 1996 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; | 1968 |
Treatment of intracranial gliomas and metastatic carcinomas by local application of cytostatic agents.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Female; Fluorouracil; Glioblastoma; | 1968 |