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fluorouracil and Meningeal Neoplasms

fluorouracil has been researched along with Meningeal Neoplasms in 20 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Meningeal Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.

Research Excerpts

ExcerptRelevanceReference
"We report a case of metastatic breast cancer with leptomeninges and multiple bone metastases that showed an excellent response to the combination of trastuzumab and capecitabine; therapeutic effect was evaluated by MRI at follow-up."7.75Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report. ( Aogi, K; Fujiuchi, N; Matsuura, K; Misumi, M; Okubo, K; Osaki, A; Saeki, T; Sano, H; Shigekawa, T; Takeuchi, H, 2009)
" We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil."7.72Response of neoplastic meningitis from solid tumors to oral capecitabine. ( Giglio, P; Groves, MD; Tremont-Lukats, IW, 2003)
"We report a durable (12-month) response to capecitabine monotherapy, shown clinically, by MRI, and by cerebrospinal fluid analysis, in a patient with leptomeningeal metastasis from breast cancer."7.72Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy. ( Remer, SE; Rogers, LR; Tejwani, S, 2004)
"We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine."7.69Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro. ( Muhr, C; Smits, A; Wang, JL; Zhang, ZJ, 1996)
"Median time from breast cancer diagnosis to the development of CNS metastasis was 48 (18-165) months."6.73Capecitabine therapy of central nervous system metastases from breast cancer. ( Abrey, LE; Deangelis, LM; Ekenel, M; Hormigo, AM; Peak, S, 2007)
"Sixty-four patients with disseminated breast cancer were treated with an aggressive chemotherapy program of prednisone, methotrexate, 5-fluorouracil, Adriamycin (doxorubicin) and cyclophosphamide (PM-FAC)."5.05Aggressive adriamycin-containing regimen (PM-FAC) in estrogen receptor-negative disseminated breast cancer. Results of a Southwest Oncology Group trial. ( Flournoy, N; Livingston, RB; Mortimer, J; Stephens, RL, 1985)
"We report a case of metastatic breast cancer with leptomeninges and multiple bone metastases that showed an excellent response to the combination of trastuzumab and capecitabine; therapeutic effect was evaluated by MRI at follow-up."3.75Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report. ( Aogi, K; Fujiuchi, N; Matsuura, K; Misumi, M; Okubo, K; Osaki, A; Saeki, T; Sano, H; Shigekawa, T; Takeuchi, H, 2009)
" We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil."3.72Response of neoplastic meningitis from solid tumors to oral capecitabine. ( Giglio, P; Groves, MD; Tremont-Lukats, IW, 2003)
"We report a durable (12-month) response to capecitabine monotherapy, shown clinically, by MRI, and by cerebrospinal fluid analysis, in a patient with leptomeningeal metastasis from breast cancer."3.72Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy. ( Remer, SE; Rogers, LR; Tejwani, S, 2004)
"Radiological and clinical evidence of acute necrosis in a meningioma following one cycle of chemotherapy with 5-fluorouracil, folinic acid, and levamisole was observed in a patient being treated for invasive rectal carcinoma."3.69Necrosis in a meningioma following systemic chemotherapy. Case report. ( Bernstein, M; Davidson, G; Erlichman, C; Villamil, A, 1994)
"We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine."3.69Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro. ( Muhr, C; Smits, A; Wang, JL; Zhang, ZJ, 1996)
"Median time from breast cancer diagnosis to the development of CNS metastasis was 48 (18-165) months."2.73Capecitabine therapy of central nervous system metastases from breast cancer. ( Abrey, LE; Deangelis, LM; Ekenel, M; Hormigo, AM; Peak, S, 2007)
"Patients with cancer commonly suffer neurologic disabilities."2.37Neurologic complications of systemic cancer. ( Patchell, RA; Posner, JB, 1985)
"Nineteen patients with brain tumors were orally administered 300 mg of UFT (a combination of FT and uracil with a molar ratio being 1:4) before operation and the concentrations of FT, 5-FU and Uracil in tumors and serum were measured by chemical assay."1.27[5-FU concentration in brain tumors after co-administration of FT and uracil]. ( Matsumoto, S; Nogaki, H; Tamaki, N; Taomoto, K, 1983)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19905 (25.00)18.7374
1990's6 (30.00)18.2507
2000's9 (45.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Paydas, S1
Bicakci, K1
Yavuz, S1
Giglio, P1
Tremont-Lukats, IW1
Groves, MD1
Rogers, LR1
Remer, SE1
Tejwani, S1
Hikino, H1
Yamada, T1
Johbara, K1
Obayashi, N1
Ozaki, N1
Stemmler, HJ1
Schmitt, M1
Harbeck, N1
Willems, A1
Bernhard, H1
Lässig, D1
Schoenberg, S1
Heinemann, V1
Tham, YL1
Hinckley, L1
Teh, BS1
Elledge, R1
Carmona-Bayonas, A1
Ekenel, M1
Hormigo, AM1
Peak, S1
Deangelis, LM1
Abrey, LE1
Shigekawa, T1
Takeuchi, H1
Misumi, M1
Matsuura, K1
Sano, H1
Fujiuchi, N1
Okubo, K1
Osaki, A1
Aogi, K1
Saeki, T1
Matsumoto, K1
Tabuchi, K1
Furuta, T1
Fujiwara, T1
Nakasone, S1
Ohnishi, R1
Moriya, Y1
Nishimoto, A1
Doi, A1
Asari, S1
Markman, M1
Nogaki, H1
Taomoto, K1
Tamaki, N1
Matsumoto, S1
Imai, T1
Kodama, S1
Yanase, T1
Ikarashi, H1
Kazama, Y1
Tanaka, K1
Bernstein, M1
Villamil, A1
Davidson, G1
Erlichman, C1
Zhang, ZJ1
Wang, JL1
Muhr, C1
Smits, A1
Deeb, LS1
Yamout, BI1
Shamseddine, AI1
Shabb, NS1
Uthman, SM1
Tippin, DB1
Reeves, W1
Vogelzang, NJ1
Huang, TY1
Arita, N1
Hayakawa, T1
Ushio, Y1
Mortimer, J1
Flournoy, N1
Livingston, RB1
Stephens, RL1
Patchell, RA1
Posner, JB1

Reviews

2 reviews available for fluorouracil and Meningeal Neoplasms

ArticleYear
Meningeal carcinomatosis as the presenting manifestation of gastric adenocarcinoma.
    The American journal of gastroenterology, 1997, Volume: 92, Issue:2

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Car

1997
Neurologic complications of systemic cancer.
    Neurologic clinics, 1985, Volume: 3, Issue:4

    Topics: Arachnoid; Bacterial Infections; Brain; Brain Neoplasms; Cerebrovascular Disorders; Cisplatin; Disse

1985

Trials

3 trials available for fluorouracil and Meningeal Neoplasms

ArticleYear
Capecitabine therapy of central nervous system metastases from breast cancer.
    Journal of neuro-oncology, 2007, Volume: 85, Issue:2

    Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma; Central Nervous S

2007
Newer techniques in cancer chemotherapy.
    Disease-a-month : DM, 1984, Volume: 30, Issue:10

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bleomycin; Bone Marrow Transplantation; Carcinoma; Ce

1984
Aggressive adriamycin-containing regimen (PM-FAC) in estrogen receptor-negative disseminated breast cancer. Results of a Southwest Oncology Group trial.
    Cancer, 1985, Nov-15, Volume: 56, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Clinical Trials a

1985

Other Studies

15 other studies available for fluorouracil and Meningeal Neoplasms

ArticleYear
Dramatic response with capecitabine after cranial radiation to the brain parenchymal and leptomeningeal metastases from lung cancer.
    European journal of internal medicine, 2009, Volume: 20, Issue:1

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Com

2009
Response of neoplastic meningitis from solid tumors to oral capecitabine.
    Journal of neuro-oncology, 2003, Volume: 65, Issue:2

    Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcin

2003
Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy.
    Neuro-oncology, 2004, Volume: 6, Issue:1

    Topics: Adult; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidi

2004
Potential role of chemo-radiation with oral capecitabine in a breast cancer patient with central nervous system relapse.
    Breast (Edinburgh, Scotland), 2006, Volume: 15, Issue:1

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocol

2006
Application of intrathecal trastuzumab (Herceptintrade mark) for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer.
    Oncology reports, 2006, Volume: 15, Issue:5

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera

2006
Long-term clinical response in leptomeningeal metastases from breast cancer treated with capecitabine monotherapy: a case report.
    Clinical breast cancer, 2006, Volume: 7, Issue:2

    Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Deoxycyt

2006
Concurrent radiotherapy and capecitabine, followed by high-dose methotrexate consolidation, provided effective palliation in a patient with leptomeningeal metastases from breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Combined Moda

2007
Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report.
    Breast cancer (Tokyo, Japan), 2009, Volume: 16, Issue:1

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplas

2009
[Combination chemotherapy of brain tumors with ACNU and 5-FU].
    Neurologia medico-chirurgica, 1983, Volume: 23, Issue:8

    Topics: Astrocytoma; Biological Products; Brain Neoplasms; Combined Modality Therapy; Drug Therapy, Combinat

1983
[5-FU concentration in brain tumors after co-administration of FT and uracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 1

    Topics: Brain Neoplasms; Drug Therapy, Combination; Fluorouracil; Glioblastoma; Humans; Meningeal Neoplasms;

1983
[A case of meningeal carcinomatosis which occurred after treatment for recurrence of the cervical carcinoma].
    Nihon Sanka Fujinka Gakkai zasshi, 1995, Volume: 47, Issue:1

    Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Combine

1995
Necrosis in a meningioma following systemic chemotherapy. Case report.
    Journal of neurosurgery, 1994, Volume: 81, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Embolizat

1994
Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro.
    Cancer letters, 1996, Feb-27, Volume: 100, Issue:1-2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carbon Radioisotopes; Cell Division; Drug Syn

1996
Diagnosis and treatment of leptomeningeal metastases in a patient with renal carcinoma responding to 5-fluorouracil and gemcitabine.
    The Journal of urology, 1999, Volume: 162, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arachnoid; Carcinom

1999
ACNU, MTX and 5-FU penetration of rat brain tissue and tumors.
    Journal of neuro-oncology, 1999, Volume: 45, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Autoradiography; Brain; Female; Flu

1999