fluorouracil has been researched along with Meningeal Neoplasms in 20 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Meningeal Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of metastatic breast cancer with leptomeninges and multiple bone metastases that showed an excellent response to the combination of trastuzumab and capecitabine; therapeutic effect was evaluated by MRI at follow-up." | 7.75 | Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report. ( Aogi, K; Fujiuchi, N; Matsuura, K; Misumi, M; Okubo, K; Osaki, A; Saeki, T; Sano, H; Shigekawa, T; Takeuchi, H, 2009) |
| " We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil." | 7.72 | Response of neoplastic meningitis from solid tumors to oral capecitabine. ( Giglio, P; Groves, MD; Tremont-Lukats, IW, 2003) |
| "We report a durable (12-month) response to capecitabine monotherapy, shown clinically, by MRI, and by cerebrospinal fluid analysis, in a patient with leptomeningeal metastasis from breast cancer." | 7.72 | Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy. ( Remer, SE; Rogers, LR; Tejwani, S, 2004) |
| "We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine." | 7.69 | Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro. ( Muhr, C; Smits, A; Wang, JL; Zhang, ZJ, 1996) |
| "Median time from breast cancer diagnosis to the development of CNS metastasis was 48 (18-165) months." | 6.73 | Capecitabine therapy of central nervous system metastases from breast cancer. ( Abrey, LE; Deangelis, LM; Ekenel, M; Hormigo, AM; Peak, S, 2007) |
| "Sixty-four patients with disseminated breast cancer were treated with an aggressive chemotherapy program of prednisone, methotrexate, 5-fluorouracil, Adriamycin (doxorubicin) and cyclophosphamide (PM-FAC)." | 5.05 | Aggressive adriamycin-containing regimen (PM-FAC) in estrogen receptor-negative disseminated breast cancer. Results of a Southwest Oncology Group trial. ( Flournoy, N; Livingston, RB; Mortimer, J; Stephens, RL, 1985) |
| "We report a case of metastatic breast cancer with leptomeninges and multiple bone metastases that showed an excellent response to the combination of trastuzumab and capecitabine; therapeutic effect was evaluated by MRI at follow-up." | 3.75 | Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report. ( Aogi, K; Fujiuchi, N; Matsuura, K; Misumi, M; Okubo, K; Osaki, A; Saeki, T; Sano, H; Shigekawa, T; Takeuchi, H, 2009) |
| " We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil." | 3.72 | Response of neoplastic meningitis from solid tumors to oral capecitabine. ( Giglio, P; Groves, MD; Tremont-Lukats, IW, 2003) |
| "We report a durable (12-month) response to capecitabine monotherapy, shown clinically, by MRI, and by cerebrospinal fluid analysis, in a patient with leptomeningeal metastasis from breast cancer." | 3.72 | Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy. ( Remer, SE; Rogers, LR; Tejwani, S, 2004) |
| "Radiological and clinical evidence of acute necrosis in a meningioma following one cycle of chemotherapy with 5-fluorouracil, folinic acid, and levamisole was observed in a patient being treated for invasive rectal carcinoma." | 3.69 | Necrosis in a meningioma following systemic chemotherapy. Case report. ( Bernstein, M; Davidson, G; Erlichman, C; Villamil, A, 1994) |
| "We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine." | 3.69 | Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro. ( Muhr, C; Smits, A; Wang, JL; Zhang, ZJ, 1996) |
| "Median time from breast cancer diagnosis to the development of CNS metastasis was 48 (18-165) months." | 2.73 | Capecitabine therapy of central nervous system metastases from breast cancer. ( Abrey, LE; Deangelis, LM; Ekenel, M; Hormigo, AM; Peak, S, 2007) |
| "Patients with cancer commonly suffer neurologic disabilities." | 2.37 | Neurologic complications of systemic cancer. ( Patchell, RA; Posner, JB, 1985) |
| "Nineteen patients with brain tumors were orally administered 300 mg of UFT (a combination of FT and uracil with a molar ratio being 1:4) before operation and the concentrations of FT, 5-FU and Uracil in tumors and serum were measured by chemical assay." | 1.27 | [5-FU concentration in brain tumors after co-administration of FT and uracil]. ( Matsumoto, S; Nogaki, H; Tamaki, N; Taomoto, K, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (25.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paydas, S | 1 |
| Bicakci, K | 1 |
| Yavuz, S | 1 |
| Giglio, P | 1 |
| Tremont-Lukats, IW | 1 |
| Groves, MD | 1 |
| Rogers, LR | 1 |
| Remer, SE | 1 |
| Tejwani, S | 1 |
| Hikino, H | 1 |
| Yamada, T | 1 |
| Johbara, K | 1 |
| Obayashi, N | 1 |
| Ozaki, N | 1 |
| Stemmler, HJ | 1 |
| Schmitt, M | 1 |
| Harbeck, N | 1 |
| Willems, A | 1 |
| Bernhard, H | 1 |
| Lässig, D | 1 |
| Schoenberg, S | 1 |
| Heinemann, V | 1 |
| Tham, YL | 1 |
| Hinckley, L | 1 |
| Teh, BS | 1 |
| Elledge, R | 1 |
| Carmona-Bayonas, A | 1 |
| Ekenel, M | 1 |
| Hormigo, AM | 1 |
| Peak, S | 1 |
| Deangelis, LM | 1 |
| Abrey, LE | 1 |
| Shigekawa, T | 1 |
| Takeuchi, H | 1 |
| Misumi, M | 1 |
| Matsuura, K | 1 |
| Sano, H | 1 |
| Fujiuchi, N | 1 |
| Okubo, K | 1 |
| Osaki, A | 1 |
| Aogi, K | 1 |
| Saeki, T | 1 |
| Matsumoto, K | 1 |
| Tabuchi, K | 1 |
| Furuta, T | 1 |
| Fujiwara, T | 1 |
| Nakasone, S | 1 |
| Ohnishi, R | 1 |
| Moriya, Y | 1 |
| Nishimoto, A | 1 |
| Doi, A | 1 |
| Asari, S | 1 |
| Markman, M | 1 |
| Nogaki, H | 1 |
| Taomoto, K | 1 |
| Tamaki, N | 1 |
| Matsumoto, S | 1 |
| Imai, T | 1 |
| Kodama, S | 1 |
| Yanase, T | 1 |
| Ikarashi, H | 1 |
| Kazama, Y | 1 |
| Tanaka, K | 1 |
| Bernstein, M | 1 |
| Villamil, A | 1 |
| Davidson, G | 1 |
| Erlichman, C | 1 |
| Zhang, ZJ | 1 |
| Wang, JL | 1 |
| Muhr, C | 1 |
| Smits, A | 1 |
| Deeb, LS | 1 |
| Yamout, BI | 1 |
| Shamseddine, AI | 1 |
| Shabb, NS | 1 |
| Uthman, SM | 1 |
| Tippin, DB | 1 |
| Reeves, W | 1 |
| Vogelzang, NJ | 1 |
| Huang, TY | 1 |
| Arita, N | 1 |
| Hayakawa, T | 1 |
| Ushio, Y | 1 |
| Mortimer, J | 1 |
| Flournoy, N | 1 |
| Livingston, RB | 1 |
| Stephens, RL | 1 |
| Patchell, RA | 1 |
| Posner, JB | 1 |
2 reviews available for fluorouracil and Meningeal Neoplasms
| Article | Year |
|---|---|
Meningeal carcinomatosis as the presenting manifestation of gastric adenocarcinoma.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Car | 1997 |
Neurologic complications of systemic cancer.
Topics: Arachnoid; Bacterial Infections; Brain; Brain Neoplasms; Cerebrovascular Disorders; Cisplatin; Disse | 1985 |
3 trials available for fluorouracil and Meningeal Neoplasms
| Article | Year |
|---|---|
Capecitabine therapy of central nervous system metastases from breast cancer.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma; Central Nervous S | 2007 |
Newer techniques in cancer chemotherapy.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bleomycin; Bone Marrow Transplantation; Carcinoma; Ce | 1984 |
Aggressive adriamycin-containing regimen (PM-FAC) in estrogen receptor-negative disseminated breast cancer. Results of a Southwest Oncology Group trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Clinical Trials a | 1985 |
15 other studies available for fluorouracil and Meningeal Neoplasms
| Article | Year |
|---|---|
Dramatic response with capecitabine after cranial radiation to the brain parenchymal and leptomeningeal metastases from lung cancer.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Com | 2009 |
Response of neoplastic meningitis from solid tumors to oral capecitabine.
Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcin | 2003 |
Durable response of breast cancer leptomeningeal metastasis to capecitabine monotherapy.
Topics: Adult; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidi | 2004 |
Potential role of chemo-radiation with oral capecitabine in a breast cancer patient with central nervous system relapse.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocol | 2006 |
Application of intrathecal trastuzumab (Herceptintrade mark) for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera | 2006 |
Long-term clinical response in leptomeningeal metastases from breast cancer treated with capecitabine monotherapy: a case report.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Deoxycyt | 2006 |
Concurrent radiotherapy and capecitabine, followed by high-dose methotrexate consolidation, provided effective palliation in a patient with leptomeningeal metastases from breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Combined Moda | 2007 |
Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplas | 2009 |
[Combination chemotherapy of brain tumors with ACNU and 5-FU].
Topics: Astrocytoma; Biological Products; Brain Neoplasms; Combined Modality Therapy; Drug Therapy, Combinat | 1983 |
[5-FU concentration in brain tumors after co-administration of FT and uracil].
Topics: Brain Neoplasms; Drug Therapy, Combination; Fluorouracil; Glioblastoma; Humans; Meningeal Neoplasms; | 1983 |
[A case of meningeal carcinomatosis which occurred after treatment for recurrence of the cervical carcinoma].
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Combine | 1995 |
Necrosis in a meningioma following systemic chemotherapy. Case report.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Embolizat | 1994 |
Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carbon Radioisotopes; Cell Division; Drug Syn | 1996 |
Diagnosis and treatment of leptomeningeal metastases in a patient with renal carcinoma responding to 5-fluorouracil and gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arachnoid; Carcinom | 1999 |
ACNU, MTX and 5-FU penetration of rat brain tissue and tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Autoradiography; Brain; Female; Flu | 1999 |