fluorouracil has been researched along with Medulloblastoma in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Both dosage and releasing time can be adjusted." | 1.27 | [Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites]. ( Himuro, H; Inoue, N; Kaetsu, I; Kitamura, K; Kubo, O; Sakairi, M; Tajika, T; Tajika, Y; Tohyama, T; Yoshida, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morrison, LC | 1 |
| McClelland, R | 1 |
| Aiken, C | 1 |
| Bridges, M | 1 |
| Liang, L | 1 |
| Wang, X | 1 |
| Di Curzio, D | 1 |
| Del Bigio, MR | 1 |
| Taylor, MD | 1 |
| Werbowetski-Ogilvie, TE | 1 |
| Tsuchida, T | 1 |
| Watanabe, E | 1 |
| Nakayama, H | 1 |
| Sasaki, A | 1 |
| Nakamura, S | 1 |
| Sasaki, M | 1 |
| Fujiwara, T | 1 |
| Nemoto, S | 1 |
| Fujiwara, K | 1 |
| Yanagibashi, K | 1 |
| Hayakawa, I | 1 |
| Nomura, K | 1 |
| Kawakami, K | 1 |
| Kawamoto, K | 1 |
| Oka, N | 1 |
| Kawamura, Y | 1 |
| Matsumura, H | 1 |
| Ito, T | 1 |
| Ohyama, A | 1 |
| Levin, VA | 1 |
| Kubo, O | 1 |
| Himuro, H | 1 |
| Inoue, N | 1 |
| Tajika, Y | 1 |
| Tajika, T | 1 |
| Tohyama, T | 1 |
| Sakairi, M | 1 |
| Yoshida, M | 1 |
| Kaetsu, I | 1 |
| Kitamura, K | 1 |
| Broder, LE | 1 |
| Rall, DP | 1 |
2 reviews available for fluorouracil and Medulloblastoma
| Article | Year |
|---|---|
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl | 1985 |
Chemotherapy of brain tumors.
Topics: Adult; Antineoplastic Agents; Azaguanine; Bleomycin; Brain Neoplasms; Child; Cyclophosphamide; Drug | 1972 |
4 other studies available for fluorouracil and Medulloblastoma
| Article | Year |
|---|---|
Deconstruction of medulloblastoma cellular heterogeneity reveals differences between the most highly invasive and self-renewing phenotypes.
Topics: Adult; Animals; Antimetabolites, Antineoplastic; CD24 Antigen; Cell Line, Tumor; Cell Movement; Cell | 2013 |
[FAR therapy in brain tumors--FT207-vitamin A-Radiation therapy (author's transl)].
Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; | 1980 |
[Flow cytometric studies of brain tumors--5: New sensitivity test of antineoplastic agents for brain tumors and its clinical application].
Topics: Animals; Antineoplastic Agents; Bleomycin; Brain Neoplasms; Cell Cycle; Cell Survival; Colony-Formin | 1986 |
[Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites].
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Implants; Dysge | 1986 |