fluorouracil has been researched along with Margins of Excision in 23 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Margins of Excision: The edges of tissue removed in a surgery for assessment of the effectiveness of a surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. When the margin is negative or not involved by tumor (e.g., CANCER) it suggests all of the tumor has been removed by the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to evaluate the efficacy and safety of 5-fluorouracil-based neoadjuvant chemoradiotherapy (NACRT) in patients with resectable/borderline resectable pancreatic ductal adenocarcinoma (PDAC)." | 3.91 | Efficacy and safety of preoperative 5-fluorouracil, cisplatin, and mitomycin C in combination with radiotherapy in patients with resectable and borderline resectable pancreatic cancer: a long-term follow-up study. ( Abe, Y; Aiura, K; Endo, Y; Fukada, J; Hori, S; Itano, O; Kitagawa, Y; Kitago, M; Masugi, Y; Nakano, Y; Oshima, G; Shinoda, M; Yagi, H, 2019) |
| "Colorectal cancer is one of the most frequent cancers in the world and between 50% and 60% of patients will develop colorectal liver metastases (CRLM) during the disease." | 2.66 | The actual management of colorectal liver metastases. ( Dorcaratto, D; Garcés-Albir, M; Huerta Álvaro, M; Muñoz-Forner, E; Pérez-Santiago, L; Roselló Keranën, S; Sabater, L, 2020) |
| "Pancreatic cancer is a lethal disease with a very poor prognosis." | 2.61 | Selecting chemotherapy for pancreatic cancer: Far away or so close? ( Shi, S; Yu, X, 2019) |
| "Chemotherapy, nodal status and resection margin according to UICC R status are univariate factors for OS after PDAC." | 1.62 | Predictive factors for long-term survival after surgery for pancreatic ductal adenocarcinoma: Making a case for standardized reporting of the resection margin using certified cancer center data. ( Obonyo, D; Stricker, I; Tannapfel, A; Uslar, VN; Weyhe, D, 2021) |
| "Endpoints were pathologic response, resection margin and overall survival (OS), disease free survival (DFS), local recurrence free survival (LRFS), and metastasis free survival (MFS)." | 1.56 | Improved Outcomes for Responders After Treatment with Induction Chemotherapy and Chemo(re)irradiation for Locally Recurrent Rectal Cancer. ( Bloemen, JG; Burger, JWA; Creemers, GJM; Kusters, M; Nederend, J; Nieuwenhuijzen, GAP; Peulen, HMU; Roef, MJ; Rutten, HJT; van Lijnschoten, G; van Zoggel, DMGI; Voogt, ELK, 2020) |
| "When treating invasive basal cell carcinoma (BCC) with Mohs micrographic surgery (MMS), including infiltrative and nodular subtypes, the goal is complete surgical removal of the tumor." | 1.56 | Topical Fluorouracil Therapy for Residual Superficial Basal Cell Carcinoma Following Mohs Micrographic Surgery. ( Housewright, C; Pederson, H; Staples, CJ, 2020) |
| "Distal resection margin (≤5 vs >5 mm) did not show any significant difference in cumulative incidence of locoregional recurrence (P=." | 1.46 | Continuous Effect of Radial Resection Margin on Recurrence and Survival in Rectal Cancer Patients Who Receive Preoperative Chemoradiation and Curative Surgery: A Multicenter Retrospective Analysis. ( Bae, JM; Jang, HS; Jeong, S; Kim, SH; Lee, JH; Lee, JW; Nam, TK; Song, JH; Sung, S, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 9 (39.13) | 2.80 |
| Authors | Studies |
|---|---|
| Endo, Y | 1 |
| Kitago, M | 1 |
| Aiura, K | 1 |
| Shinoda, M | 1 |
| Yagi, H | 1 |
| Abe, Y | 1 |
| Oshima, G | 1 |
| Hori, S | 1 |
| Nakano, Y | 1 |
| Itano, O | 1 |
| Fukada, J | 1 |
| Masugi, Y | 1 |
| Kitagawa, Y | 1 |
| Suzuki, T | 1 |
| Okamura, A | 1 |
| Watanabe, M | 1 |
| Mine, S | 1 |
| Imamura, Y | 1 |
| Asari, T | 1 |
| Osumi, H | 1 |
| Nakayama, I | 1 |
| Ichimura, T | 1 |
| Ogura, M | 1 |
| Ooki, A | 1 |
| Takahari, D | 1 |
| Yamaguchi, K | 1 |
| Chin, K | 1 |
| van Roessel, S | 1 |
| Strijker, M | 1 |
| Steyerberg, EW | 1 |
| Groen, JV | 1 |
| Mieog, JS | 1 |
| Groot, VP | 1 |
| He, J | 2 |
| De Pastena, M | 1 |
| Marchegiani, G | 1 |
| Bassi, C | 1 |
| Suhool, A | 1 |
| Jang, JY | 2 |
| Busch, OR | 1 |
| Halimi, A | 1 |
| Zarantonello, L | 1 |
| Groot Koerkamp, B | 1 |
| Samra, JS | 1 |
| Mittal, A | 1 |
| Gill, AJ | 1 |
| Bolm, L | 1 |
| van Eijck, CH | 1 |
| Abu Hilal, M | 1 |
| Del Chiaro, M | 1 |
| Keck, T | 1 |
| Alseidi, A | 1 |
| Wolfgang, CL | 2 |
| Malleo, G | 1 |
| Besselink, MG | 1 |
| Voogt, ELK | 1 |
| van Zoggel, DMGI | 1 |
| Kusters, M | 1 |
| Nieuwenhuijzen, GAP | 1 |
| Bloemen, JG | 1 |
| Peulen, HMU | 1 |
| Creemers, GJM | 1 |
| van Lijnschoten, G | 1 |
| Nederend, J | 1 |
| Roef, MJ | 1 |
| Burger, JWA | 1 |
| Rutten, HJT | 1 |
| Pederson, H | 1 |
| Staples, CJ | 1 |
| Housewright, C | 1 |
| Bußmann, L | 1 |
| Laban, S | 1 |
| Wittekindt, C | 1 |
| Stromberger, C | 1 |
| Tribius, S | 1 |
| Möckelmann, N | 1 |
| Böttcher, A | 1 |
| Betz, CS | 1 |
| Klussmann, JP | 1 |
| Budach, V | 1 |
| Muenscher, A | 1 |
| Busch, CJ | 1 |
| Pérez-Santiago, L | 1 |
| Dorcaratto, D | 1 |
| Garcés-Albir, M | 1 |
| Muñoz-Forner, E | 1 |
| Huerta Álvaro, M | 1 |
| Roselló Keranën, S | 1 |
| Sabater, L | 1 |
| Kim, BH | 1 |
| Kim, K | 1 |
| Kwon, W | 1 |
| Kim, H | 2 |
| Lee, KH | 1 |
| Oh, DY | 1 |
| Lee, KB | 1 |
| Chie, EK | 1 |
| Schmocker, RK | 1 |
| Delitto, D | 1 |
| Wright, MJ | 1 |
| Ding, D | 1 |
| Cameron, JL | 1 |
| Lafaro, KJ | 1 |
| Burns, WR | 1 |
| Burkhart, RA | 1 |
| Weyhe, D | 1 |
| Obonyo, D | 1 |
| Uslar, VN | 1 |
| Stricker, I | 1 |
| Tannapfel, A | 1 |
| Sung, S | 1 |
| Kim, SH | 1 |
| Lee, JH | 2 |
| Nam, TK | 1 |
| Jeong, S | 1 |
| Jang, HS | 1 |
| Song, JH | 1 |
| Lee, JW | 1 |
| Bae, JM | 1 |
| Epelboym, I | 1 |
| Zenati, MS | 1 |
| Hamad, A | 1 |
| Steve, J | 1 |
| Lee, KK | 1 |
| Bahary, N | 1 |
| Hogg, ME | 1 |
| Zeh, HJ | 1 |
| Zureikat, AH | 1 |
| Miller, CL | 1 |
| Taylor, MS | 1 |
| Qadan, M | 1 |
| Deshpande, V | 1 |
| Worthington, S | 1 |
| Smalley, R | 1 |
| Collura, C | 1 |
| Ryan, DP | 1 |
| Allen, JN | 1 |
| Blaszkowsky, LS | 1 |
| Clark, JW | 1 |
| Murphy, JE | 1 |
| Parikh, AR | 1 |
| Berger, D | 1 |
| Tanabe, KK | 1 |
| Lillemoe, KD | 1 |
| Ferrone, CR | 1 |
| Berriochoa, CA | 1 |
| Abdel-Wahab, M | 1 |
| Leyrer, CM | 1 |
| Khorana, A | 1 |
| Matthew Walsh, R | 1 |
| Kumar, AMS | 1 |
| Ghaneh, P | 1 |
| Kleeff, J | 1 |
| Halloran, CM | 1 |
| Raraty, M | 1 |
| Jackson, R | 1 |
| Melling, J | 1 |
| Jones, O | 1 |
| Palmer, DH | 1 |
| Cox, TF | 1 |
| Smith, CJ | 1 |
| O'Reilly, DA | 1 |
| Izbicki, JR | 1 |
| Scarfe, AG | 1 |
| Valle, JW | 1 |
| McDonald, AC | 1 |
| Carter, R | 1 |
| Tebbutt, NC | 1 |
| Goldstein, D | 1 |
| Padbury, R | 1 |
| Shannon, J | 1 |
| Dervenis, C | 1 |
| Glimelius, B | 1 |
| Deakin, M | 1 |
| Anthoney, A | 1 |
| Lerch, MM | 1 |
| Mayerle, J | 1 |
| Oláh, A | 1 |
| Rawcliffe, CL | 1 |
| Campbell, F | 1 |
| Strobel, O | 1 |
| Büchler, MW | 1 |
| Neoptolemos, JP | 1 |
| Jansen, MH | 1 |
| Appelen, D | 1 |
| Nelemans, PJ | 1 |
| Winnepenninckx, VJ | 1 |
| Kelleners-Smeets, NWJ | 1 |
| Mosterd, K | 1 |
| Fokas, E | 1 |
| Ströbel, P | 1 |
| Fietkau, R | 1 |
| Ghadimi, M | 1 |
| Liersch, T | 1 |
| Grabenbauer, GG | 1 |
| Hartmann, A | 1 |
| Kaufmann, M | 1 |
| Sauer, R | 1 |
| Graeven, U | 1 |
| Hoffmanns, H | 1 |
| Raab, HR | 1 |
| Hothorn, T | 1 |
| Wittekind, C | 1 |
| Rödel, C | 1 |
| Jin, Z | 2 |
| Hartgers, ML | 1 |
| Sanhueza, CT | 1 |
| Shubert, CR | 1 |
| Alberts, SR | 1 |
| Truty, MJ | 2 |
| Muppa, P | 1 |
| Nagorney, DM | 2 |
| Smyrk, TC | 1 |
| Hassan, M | 1 |
| Mahipal, A | 2 |
| Berardi, G | 1 |
| De Man, M | 1 |
| Laurent, S | 1 |
| Smeets, P | 1 |
| Tomassini, F | 1 |
| Ariotti, R | 1 |
| Hoorens, A | 1 |
| van Dorpe, J | 1 |
| Varin, O | 1 |
| Geboes, K | 1 |
| Troisi, RI | 1 |
| Milosevic, M | 1 |
| Lazarevic, M | 1 |
| Toljic, B | 1 |
| Simonovic, J | 1 |
| Trisic, D | 1 |
| Nikolic, N | 1 |
| Petrovic, M | 1 |
| Milasin, J | 1 |
| Shi, S | 1 |
| Yu, X | 1 |
| Huffman, BM | 1 |
| Yadav, S | 1 |
| Patel, S | 1 |
| McWilliams, RR | 1 |
| Halfdanarson, TR | 1 |
| Katz, MH | 1 |
| Shi, Q | 1 |
| Ahmad, SA | 1 |
| Herman, JM | 1 |
| Marsh, Rde W | 1 |
| Collisson, E | 1 |
| Schwartz, L | 1 |
| Frankel, W | 1 |
| Martin, R | 1 |
| Conway, W | 1 |
| Truty, M | 1 |
| Kindler, H | 1 |
| Lowy, AM | 1 |
| Bekaii-Saab, T | 1 |
| Philip, P | 1 |
| Talamonti, M | 1 |
| Cardin, D | 1 |
| LoConte, N | 1 |
| Shen, P | 1 |
| Hoffman, JP | 1 |
| Venook, AP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Effectiveness Trial of Transoral Head and Neck Surgery Followed by Adjuvant Radio(Chemo)Therapy Versus Primary Radiochemotherapy for Oropharyngeal Cancer[NCT03691441] | Phase 4 | 280 participants (Anticipated) | Interventional | 2018-01-05 | Active, not recruiting | ||
| European Study Group For Pancreatic Cancer - Trial 3[NCT00058201] | Phase 3 | 1,030 participants (Anticipated) | Interventional | 2001-07-31 | Completed | ||
| Surgical Excision Versus Photodynamic Therapy and Topical 5-fluorouracil in Treatment of Bowen's Disease: a Multicenter Randomized Controlled Trial[NCT03909646] | Phase 4 | 250 participants (Anticipated) | Interventional | 2019-05-27 | Recruiting | ||
| Neoadjuvant FOLFIRINOX and Chemoradiation Followed by Definitive Surgery and Postoperative Gemcitabine for Patients With Borderline Resectable Pancreatic Adenocarcinoma: An Intergroup Single-Arm Pilot Study[NCT01821612] | Early Phase 1 | 23 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| A Study of Preoperative FOLFIRINOX For Potentially Curable Pancreatic Cancer[NCT03167112] | Phase 2 | 20 participants (Anticipated) | Interventional | 2017-07-03 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Margins of Excision
| Article | Year |
|---|---|
The actual management of colorectal liver metastases.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Electroporation; | 2020 |
Selecting chemotherapy for pancreatic cancer: Far away or so close?
Topics: Albumins; Antigens, Tumor-Associated, Carbohydrate; Antineoplastic Combined Chemotherapy Protocols; | 2019 |
4 trials available for fluorouracil and Margins of Excision
17 other studies available for fluorouracil and Margins of Excision
| Article | Year |
|---|---|
Efficacy and safety of preoperative 5-fluorouracil, cisplatin, and mitomycin C in combination with radiotherapy in patients with resectable and borderline resectable pancreatic cancer: a long-term follow-up study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carc | 2019 |
Neoadjuvant Chemoradiotherapy with Cisplatin Plus Fluorouracil for Borderline Resectable Esophageal Squamous Cell Carcinoma.
Topics: Adult; Aged; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Esophage | 2020 |
International validation and update of the Amsterdam model for prediction of survival after pancreatoduodenectomy for pancreatic cancer.
Topics: Aged; Antineoplastic Agents; Area Under Curve; Capecitabine; Carcinoma, Pancreatic Ductal; Chemoradi | 2020 |
Improved Outcomes for Responders After Treatment with Induction Chemotherapy and Chemo(re)irradiation for Locally Recurrent Rectal Cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Combined Modality Therapy; Femal | 2020 |
Topical Fluorouracil Therapy for Residual Superficial Basal Cell Carcinoma Following Mohs Micrographic Surgery.
Topics: Administration, Cutaneous; Aged; Carcinoma, Basal Cell; Chemotherapy, Adjuvant; Female; Fluorouracil | 2020 |
Survival benefit of adjuvant chemoradiotherapy for positive or close resection margin after curative resection of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Case | 2020 |
Impact of Margin Status on Survival in Patients with Pancreatic Ductal Adenocarcinoma Receiving Neoadjuvant Chemotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Chemotherapy, Ad | 2021 |
Predictive factors for long-term survival after surgery for pancreatic ductal adenocarcinoma: Making a case for standardized reporting of the resection margin using certified cancer center data.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Chemotherapy, Ad | 2021 |
Continuous Effect of Radial Resection Margin on Recurrence and Survival in Rectal Cancer Patients Who Receive Preoperative Chemoradiation and Curative Surgery: A Multicenter Retrospective Analysis.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Agents; Capecit | 2017 |
Analysis of Perioperative Chemotherapy in Resected Pancreatic Cancer: Identifying the Number and Sequence of Chemotherapy Cycles Needed to Optimize Survival.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Deoxycytidine; Female; | 2017 |
Prognostic Significance of Surgical Margin Size After Neoadjuvant FOLFOX and/or FOLFIRI for Colorectal Liver Metastases.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dis | 2017 |
Neoadjuvant chemoradiation for non-metastatic pancreatic cancer increases margin-negative and node-negative rates at resection.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherap | 2017 |
Bowen's Disease: Long-term Results of Treatment with 5-Fluorouracil Cream, Photodynamic Therapy or Surgical Excision.
Topics: Administration, Cutaneous; Antimetabolites, Antineoplastic; Bowen's Disease; Fluorouracil; Humans; M | 2018 |
Prognostic factors and benefits of adjuvant therapy after pancreatoduodenectomy for ampullary adenocarcinoma: Mayo Clinic experience.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Ampulla of Vater; Antimetabolites, Antin | 2018 |
Radiologic and pathologic response to neoadjuvant chemotherapy predicts survival in patients undergoing the liver-first approach for synchronous colorectal liver metastases.
Topics: Aged; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Bevacizu | 2018 |
Characterization of stem-like cancer cells in basal cell carcinoma and its surgical margins.
Topics: 5'-Nucleotidase; Antineoplastic Agents; Biomarkers; Carcinoma, Basal Cell; Cell Survival; Cisplatin; | 2018 |
Novel Prognostic Factors in Resected Small Bowel Adenocarcinoma.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Pr | 2019 |