fluorouracil has been researched along with Marasmus in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil was given orally (50 mg/kg/day for 5 days)." | 1.39 | Effect of protein malnutrition on the metabolism and toxicity of cisplatin, 5-fluorouracil and mitomycin C in rat stomach. ( Abd-Elgawad, HM; Motawi, TK; Shahin, NN, 2013) |
| " 19F-NMRS can noninvasively identify these alterations of 5-FU metabolism in vivo and may serve as a useful guide to determining chemotherapy dosage adjustments to reduce toxicity." | 1.29 | The effect of dietary protein depletion on hepatic 5-fluorouracil metabolism. ( Daly, JM; Davis, LE; Kressel, HY; Lenkinski, RE; Shinkwin, MA, 1993) |
| "Mice were used to study the effects of protein-calorie malnutrition and its reversal on granulocyte-macrophage production and fluorouracil's toxic effect on bone marrow." | 1.27 | Effects of protein-calorie malnutrition and refeeding on fluorouracil toxicity. ( Foster, RS; Gamelli, RL, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Motawi, TK | 1 |
| Abd-Elgawad, HM | 1 |
| Shahin, NN | 1 |
| Borelli, P | 1 |
| Barros, FE | 1 |
| Nakajima, K | 1 |
| Blatt, SL | 1 |
| Beutler, B | 1 |
| Pereira, J | 1 |
| Tsujita, M | 1 |
| Favero, GM | 1 |
| Fock, RA | 1 |
| Gamelli, RL | 2 |
| Foster, RS | 2 |
| Akimoto, M | 1 |
| Abe, R | 1 |
| Kasai, M | 1 |
| Davis, LE | 1 |
| Lenkinski, RE | 1 |
| Shinkwin, MA | 1 |
| Kressel, HY | 1 |
| Daly, JM | 1 |
6 other studies available for fluorouracil and Marasmus
| Article | Year |
|---|---|
Effect of protein malnutrition on the metabolism and toxicity of cisplatin, 5-fluorouracil and mitomycin C in rat stomach.
Topics: Animals; Carbon-Sulfur Lyases; Cisplatin; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dihydrou | 2013 |
Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates.
Topics: Animals; Bone Marrow Cells; Cell Cycle; Cell Proliferation; Colony-Forming Units Assay; Flow Cytomet | 2009 |
Effects of protein-calorie malnutrition and refeeding on fluorouracil toxicity.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Dietary Proteins; Fluorouracil; Granulocytes; Hematopoietic | 1983 |
[Effects of protein calorie intake on immuno- and chemotherapy].
Topics: Animals; Dietary Proteins; Female; Fluorouracil; Killer Cells, Natural; Lentinan; Mammary Neoplasms, | 1982 |
The effect of dietary protein depletion on hepatic 5-fluorouracil metabolism.
Topics: Animals; Dietary Proteins; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Liver; Magnetic Resonan | 1993 |
Protein-calorie malnutrition and 5-fluorouracil toxicity.
Topics: Animals; Bone Marrow; Clone Cells; Fluorouracil; Granulocytes; Macrophages; Mice; Mice, Inbred C57BL | 1979 |