fluorouracil has been researched along with Malignant Carcinoid Syndrome in 23 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Malignant Carcinoid Syndrome: A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred eighteen patients with metastatic carcinoid tumor were randomized to treatment with streptozotocin combined with cyclophosphamide or with 5-fluorouracil (5-FU)." | 5.04 | Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome. ( Hanley, JA; Moertel, CG, 1979) |
| "In 2 patients with the malignant carcinoid syndrome, a Swam-Ganz balloon tip, flow-directed catheter was used to occlude hepatic arterial flow and perfuse hepatic metastases with 5-fluorouracil." | 3.66 | Hepatic artery occlusion with perfusion in the treatment of carcinoid syndrome. ( Costanzi, JJ; Helmer, RE; Morettin, LB, 1981) |
| " Increasing ascites requiring repeated paracentesis had not responded to chemotherapy including infusion of 5-fluorouracil and vincristine into the coeliac artery." | 3.65 | Carcinoid heart disease: successful tricuspid valve replacement. ( Honey, M; Paneth, M, 1975) |
| "Certainly in treatment of the carcinoid tumor surgery has a well-established curative and palliative potential." | 2.36 | Treatment of the carcinoid tumor and the malignant carcinoid syndrome. ( Moertel, CG, 1983) |
| "A malignant carcinoid syndrome was present in 8 patients." | 1.31 | [Surgical and adjuvant therapy of neuroendocrine tumors of the gastrointestinal tract and their metastases. A retrospective analysis of personal patient group]. ( Hallfeldt, KK; Jückstock, H; Ladurner, R; Mussack, T; Schmidbauer, S; Trupka, AW, 2001) |
| "Although advanced gastrointestinal cancer is the most commonplace problem encountered by the medical oncologist, this group of diseases has proved exceedingly resistant to past chemotherapy efforts." | 1.25 | Clinical management of advanced gastrointestinal cancer. ( Moertel, CG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (82.61) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rondina, MT | 1 |
| Fang, JC | 1 |
| Yu, M | 1 |
| Hinchliffe, E | 1 |
| Allcock, RL | 1 |
| Mansoor, W | 1 |
| Myers, MA | 1 |
| REED, ML | 1 |
| KUIPERS, FM | 1 |
| VAITKEVICIUS, VK | 2 |
| CLARK, MD | 1 |
| DRAKE, EH | 2 |
| EYLER, WR | 1 |
| BRENNAN, MJ | 1 |
| TALLEY, RW | 1 |
| POZNANSKI, AK | 1 |
| BRUSH, BE | 1 |
| NASH, DT | 1 |
| BRIN, M | 1 |
| MENGEL, CE | 1 |
| Rasenack, U | 1 |
| Caspary, W | 1 |
| Moertel, CG | 4 |
| Bengmark, S | 1 |
| Nobin, A | 1 |
| Jeppsson, B | 1 |
| Tranberg, KG | 1 |
| Helmer, RE | 1 |
| Morettin, LB | 1 |
| Costanzi, JJ | 1 |
| Schmidbauer, S | 1 |
| Ladurner, R | 1 |
| Jückstock, H | 1 |
| Trupka, AW | 1 |
| Mussack, T | 1 |
| Hallfeldt, KK | 1 |
| Hanley, JA | 1 |
| Farndon, JR | 1 |
| Jugdutt, BI | 1 |
| Watanabe, M | 1 |
| Turner, FW | 1 |
| Honey, M | 1 |
| Paneth, M | 1 |
| Oberg, K | 2 |
| Eriksson, B | 1 |
| Norheim, I | 1 |
| Alm, G | 1 |
| Vyshinskaia, GV | 1 |
| Bassalyk, LS | 1 |
| Vasil'ev, SA | 1 |
| Gromova, NV | 1 |
| Nadezhdina, TM | 1 |
| Battersby, C | 1 |
| Egerton, WS | 1 |
| Castiello, RJ | 1 |
| Lynch, PJ | 1 |
| Karkos, J | 1 |
3 reviews available for fluorouracil and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
THERAPY OF THE MALIGNANT CARCINOID SYNDROME.
Topics: Anti-Allergic Agents; Antihypertensive Agents; Cyclophosphamide; Fluorouracil; Histamine H1 Antagoni | 1965 |
Treatment of the carcinoid tumor and the malignant carcinoid syndrome.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Appendectomy; Ap | 1983 |
[Carcinoid: problems of pathology, biochemistry and therapy].
Topics: Angiotensin II; Animals; Blood Pressure; Cyclophosphamide; Fluorouracil; Guinea Pigs; Histocytochemi | 1971 |
2 trials available for fluorouracil and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoid Tumor; Child; Clinical Trials as Topic; Cy | 1979 |
Treatment of malignant carcinoid tumors: a randomized controlled study of streptozocin plus 5-FU and human leukocyte interferon.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Hydroxyindoleace | 1989 |
18 other studies available for fluorouracil and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
Episodic fevers as a novel feature of the carcinoid syndrome.
Topics: Antineoplastic Combined Chemotherapy Protocols; Fever; Fluorouracil; Humans; Male; Malignant Carcino | 2008 |
A patient with a metastatic gastroenteropancreatic endocrine carcinoma causing hyperinsulinaemic hypoglycaemia and the carcinoid syndrome.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carcinoma; Fl | 2011 |
TREATMENT OF DISSEMINATED CARCINOID TUMORS INCLUDING HEPATIC-ARTERY CATHETERIZATION.
Topics: Antineoplastic Agents; Carcinoid Tumor; Catheterization; Fluorouracil; Hepatic Artery; Humans; Liver | 1963 |
5-FLUOROURACIL TREATMENT OF LIVER METASTASES BY CONTINUOUS HEPATIC ARTERY INFUSION VIA COURNAND CATHETER: RESULTS AND SUITABILITY FOR INTENSIVE POSTSURGICAL ADJUVANT CHEMOTHERAPY.
Topics: Adenocarcinoma; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Gast | 1963 |
MALABSORPTION IN MALIGNANT CARCINOID WITH NORMAL 5 HIAA.
Topics: Blood Chemical Analysis; Celiac Disease; Fluorouracil; Hydroxyindoleacetic Acid; Indoleacetic Acids; | 1964 |
[Therapy of carcinoid and the carcinoid syndrome].
Topics: Aminocaproic Acid; Aprotinin; Carcinoma, Squamous Cell; Cyproheptadine; Doxorubicin; Embolization, T | 1983 |
Transient repeated dearterialization combined with intra-arterial infusion of oncolytic drugs in the treatment of liver tumors.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Cyclophosphamide; Duod | 1983 |
Hepatic artery occlusion with perfusion in the treatment of carcinoid syndrome.
Topics: Adult; Aged; Catheterization; Female; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Male; M | 1981 |
[Surgical and adjuvant therapy of neuroendocrine tumors of the gastrointestinal tract and their metastases. A retrospective analysis of personal patient group].
Topics: Adult; Aged; Antineoplastic Agents; Chemoembolization, Therapeutic; Chemotherapy, Adjuvant; Combined | 2001 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Ther | 1975 |
Walter Hubert lecture Chemotherapy of upper gastrointestinal carcinoma.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, S | 1976 |
The carcinoid syndrome: methods of treatment and recent experience with hepatic artery ligation and infusion.
Topics: Female; Fluorouracil; Heart Failure; Hepatic Artery; Humans; Hydroxyindoleacetic Acid; Ileum; Intest | 1977 |
Hepatic artery ligation in treatment of carcinoid syndrome.
Topics: Aged; Angiography; Cyclophosphamide; Female; Fluorouracil; Hepatic Artery; Humans; Hydroxyindoleacet | 1975 |
Carcinoid heart disease: successful tricuspid valve replacement.
Topics: Adult; Ascites; Carcinoid Heart Disease; Carcinoid Tumor; Cardiac Catheterization; Edema; Female; Fl | 1975 |
The role of interferons in the management of carcinoid tumours.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluorouracil; Humans; Int | 1991 |
[Clinico-biochemical findings in malignant carcinoid during cytostatic therapy (description of a case)].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; | 1986 |
A carcinoid saga.
Topics: Anesthesia, General; Aprotinin; Carcinoid Tumor; Female; Fluorouracil; Hepatectomy; Humans; Hydroxyi | 1974 |
Pellagra and the carcinoid syndrome.
Topics: Digitalis Glycosides; Diuretics; Female; Fluorouracil; Humans; Malignant Carcinoid Syndrome; Middle | 1972 |